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http://dx.doi.org/10.14348/molcells.2016.0085

Post-Translational Regulation of miRNA Pathway Components, AGO1 and HYL1, in Plants  

Cho, Seok Keun (Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University)
Ryu, Moon Young (Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University)
Shah, Pratik (Department of Biomedical Engineering, University of California Irvine)
Poulsen, Christian Peter (Carlsberg Research Laboratory)
Yang, Seong Wook (Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University)
Publication Information
Molecules and Cells / v.39, no.8, 2016 , pp. 581-586 More about this Journal
Abstract
Post-translational modifications (PTMs) of proteins are essential to increase the functional diversity of the proteome. By adding chemical groups to proteins, or degrading entire proteins by phosphorylation, glycosylation, ubiquitination, neddylation, acetylation, lipidation, and proteolysis, the complexity of the proteome increases, and this then influences most biological processes. Although small RNAs are crucial regulatory elements for gene expression in most eukaryotes, PTMs of small RNA microprocessor and RNA silencing components have not been extensively investigated in plants. To date, several studies have shown that the proteolytic regulation of AGOs is important for host-pathogen interactions. DRB4 is regulated by the ubiquitin-proteasome system, and the degradation of HYL1 is modulated by a de-etiolation repressor, COP1, and an unknown cytoplasmic protease. Here, we discuss current findings on the PTMs of microprocessor and RNA silencing components in plants.
Keywords
AGO1; autophagy; HYL1; miRNA; protease; proteolysis; UPS;
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