Browse > Article
http://dx.doi.org/10.5223/pghn.2016.19.2.110

The Association between Helicobacter pylori Infection and Body Weight among Children  

Choi, Jun Sik (Department of Pediatrics, Konyang University College of Medicine)
Ko, Kyung Og (Department of Pediatrics, Konyang University College of Medicine)
Lim, Jae Woo (Department of Pediatrics, Konyang University College of Medicine)
Cheon, Eun Jeong (Department of Pediatrics, Konyang University College of Medicine)
Lee, Gyung Min (Department of Pediatrics, Konyang University College of Medicine)
Yoon, Jung Min (Department of Pediatrics, Konyang University College of Medicine)
Publication Information
Pediatric Gastroenterology, Hepatology & Nutrition / v.19, no.2, 2016 , pp. 110-115 More about this Journal
Abstract
Purpose: We performed to reveal the association between the Helicobacter pylori infection and body weight among children. Methods: Out retrospective study included patients who underwent the H. pylori immunoglobulin G testing at Konyang University Hospital between March 2011 and June 2014. These patients were classified as seropositive (28 boys, 27 girls; mean age: $9.89{\pm}3.28years$) or seronegative (55 boys, 54 girls; mean age: $9.84{\pm}3.02years$). Next, we compared various characteristics between the seropositive and negative groups, as well as between obese children (body weight ${\geq}90th$ percentile) and non-obese children (body weight <90th percentile). Furthermore, we compared the change in body weight after 2 months of treatment with amoxicillin, clarithromycin and omeprazole among the 55 seropositive children (14 treated children and 41 non-treated children). Results: There were no differences in the weights and laboratory data for the 55 seropositive children and 109 seronegative children (weight; $40.96{\pm}18.11kg$ vs. $36.85{\pm}13.72kg$, respectively; p=0.14). And, there was no difference in the prevalence of H. pylori infection among the 29 obese and 135 non-obese children (p=0.581). However, after 2 months of eradication, the 14 treated patients exhibited a significant weight gain ($+0.91{\pm}0.52kg$), compared to the 41 non-treated patients ($-0.29{\pm}1.16kg$, p=0.025). Conclusion: Our findings present that obesity was not associated with the H. pylori infection, although H. pylori eradication led to significant increase in body weight.
Keywords
Helicobacter; Obesity; Body weight; Disease eradication; Child;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Chimienti G, Russo F, Lamanuzzi BL, Nardulli M, Messa C, Di Leo A, et al. Helicobacter pylori is associated with modified lipid profile: impact on lipoprotein(a). Clin Biochem 2003;36:359-65.   DOI
2 Arslan E, Atilgan H, Yavasoglu I. The prevalence of Helicobacter pylori in obese subjects. Eur J Intern Med 2009;20:695-7.   DOI
3 Ioannou GN, Weiss NS, Kearney DJ. Is Helicobacter pylori seropositivity related to body mass index in the United States? Aliment Pharmacol Ther 2005;21:765-72.   DOI
4 Cho I, Blaser MJ, Francois F, Mathew JP, Ye XY, Goldberg JD, et al. Helicobacter pylori and overweight status in the United States: data from the Third National Health and Nutrition Examination Survey. Am J Epidemiol 2005;162:579-84.   DOI
5 Azuma T, Suto H, Ito Y, Muramatsu A, Ohtani M, Dojo M, et al. Eradication of Helicobacter pylori infection induces an increase in body mass index. Aliment Pharmacol Ther 2002;16 Suppl 2:240-4.   DOI
6 Furuta T, Shirai N, Xiao F, Takashima M, Hanai H. Effect of Helicobacter pylori infection and its eradication on nutrition. Aliment Pharmacol Ther 2002; 16:799-806.   DOI
7 Kamada T, Hata J, Kusunoki H, Ito M, Tanaka S, Kawamura Y, et al. Eradication of Helicobacter pylori increases the incidence of hyperlipidaemia and obesity in peptic ulcer patients. Dig Liver Dis 2005;37:39-43.   DOI
8 Rosenstock SJ, Jorgensen T, Andersen LP, Bonnevie O. Association of Helicobacter pylori infection with lifestyle, chronic disease, body-indices, and age at menarche in Danish adults. Scand J Public Health 2000;28:32-40.   DOI
9 Thjodleifsson B, Olafsson I, Gislason D, Gislason T, Jogi R, Janson C. Infections and obesity: a multinational epidemiological study. Scand J Infect Dis 2008;40:381-6.   DOI
10 Azuma T, Suto H, Ito Y, Ohtani M, Dojo M, Kuriyama M, et al. Gastric leptin and Helicobacter pylori infection. Gut 2001;49:324-9.   DOI
11 Fujiwara Y, Higuchi K, Arafa UA, Uchida T, Tominaga K, Watanabe T, et al. Long-term effect of Helicobacter pylori eradication on quality of life, body mass index, and newly developed diseases in Japanese patients with peptic ulcer disease. Hepatogastroenterology 2002;49:1298-302.
12 Loffeld RJ. Helicobacter pylori, obesity and gastro-oesophageal reflux disease. Is there a relation? A personal view. Neth J Med 2005;63:344-7.
13 Akamizu T, Kangawa K. Translational research on the clinical applications of ghrelin. Endocr J 2006;53: 585-91.   DOI
14 Williams DL, Cummings DE. Regulation of ghrelin in physiologic and pathophysiologic states. J Nutr 2005;135:1320-5.   DOI
15 Chen CY, Asakawa A, Fujimiya M, Lee SD, Inui A. Ghrelin gene products and the regulation of food intake and gut motility. Pharmacol Rev 2009;61:430-81.   DOI
16 Kawashima J, Ohno S, Sakurada T, Takabayashi H, Kudo M, Ro S, et al. Circulating acylated ghrelin level decreases in accordance with the extent of atrophic gastritis. J Gastroenterol 2009;44:1046-54.   DOI
17 Gunji T, Matsuhashi N, Sato H, Fujibayashi K, Okumura M, Sasabe N, et al. Helicobacter pylori infection is significantly associated with metabolic syndrome in the Japanese population. Am J Gastroenterol 2008;103:3005-10.   DOI
18 de Oliveira AM, Rocha GA, Queiroz DM, Mendes EN, de Carvalho AS, Ferrari TC, et al. Evaluation of enzyme-linked immunosorbent assay for the diagnosis of Helicobacter pylori infection in children from different age groups with and without duodenal ulcer. J Pediatr Gastroenterol Nutr 1999;28:157-61.   DOI
19 Arslan D, Kendirci M, Kurtoglu S, Kula M. Helicobacter pylori infection in children with insulin dependent diabetes mellitus. J Pediatr Endocrinol Metab 2000;13: 553-6.
20 Senturk O, Canturk Z, Cetinarslan B, Ercin C, Hulagu S, Canturk NZ. Prevalence and comparisons of five different diagnostic methods for Helicobacter pylori in diabetic patients. Endocr Res 2001;27:179-89.   DOI
21 Quatrini M, Boarino V, Ghidoni A, Baldassarri AR, Bianchi PA, Bardella MT. Helicobacter pylori prevalence in patients with diabetes and its relationship to dyspeptic symptoms. J Clin Gastroenterol 2001;32: 215-7.   DOI
22 Gulcelik NE, Kaya E, Demirbas B, Culha C, Koc G, Ozkaya M, et al. Helicobacter pylori prevalence in diabetic patients and its relationship with dyspepsia and autonomic neuropathy. J Endocrinol Invest 2005;28: 214-7.   DOI
23 Niccoli G, Franceschi F, Cosentino N, Giupponi B, De Marco G, Merra G, et al. Coronary atherosclerotic burden in patients with infection by CagA-positive strains of Helicobacter pylori. Coron Artery Dis 2010; 21:217-21.   DOI
24 Laurila A, Bloigu A, Nayha S, Hassi J, Leinonen M, Saikku P. Association of Helicobacter pylori infection with elevated serum lipids. Atherosclerosis 1999;142: 207-10.   DOI
25 Hoffmeister A, Rothenbacher D, Bode G, Persson K, Marz W, Nauck MA, et al. Current infection with Helicobacter pylori, but not seropositivity to Chlamydia pneumoniae or cytomegalovirus, is associated with an atherogenic, modified lipid profile. Arterioscler Thromb Vasc Biol 2001;21:427-32.   DOI
26 Jafarzadeh A, Esmaeeli-Nadimi A, Nemati M, Tahmasbi M, Ahmadi P. Serum concentrations of Helicobacter pylori IgG and the virulence factor CagA in patients with ischaemic heart disease. East Mediterr Health J 2010;16:1039-44.   DOI
27 Grau AJ, Buggle F, Lichy C, Brandt T, Becher H, Rudi J. Helicobacter pylori infection as an independent risk factor for cerebral ischemia of atherothrombotic origin. J Neurol Sci 2001;186:1-5.   DOI
28 Diomedi M, Stanzione P, Sallustio F, Leone G, Renna A, Misaggi G, et al. Cytotoxin-associated Gene-A-positive Helicobacter pylori strains infection increases the risk of recurrent atherosclerotic stroke. Helicobacter 2008;13:525-31.   DOI
29 Kopacova M, Bures J, Koupil I, Rejchrt S, Vorisek V, Seifert B, et al; European Society for Primary Care Gastroenterology. Body indices and basic vital signs in Helicobacter pylori positive and negative persons. Eur J Epidemiol 2007;22:67-75.   DOI
30 Kamada T, Sugiu K, Haruma K. Development of obesity and hyperlipidemia after eradication of Helicobacter pylori. Nihon Rinsho 2005;63 Suppl 11:536-8.