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http://dx.doi.org/10.5999/aps.2013.40.6.697

The Effects of Topical Agent (Kelo-Cote or Contractubex) Massage on the Thickness of Post-Burn Scar Tissue Formed in Rats  

Ko, Won Jin (Department of Plastic and Reconstructive Surgery, Wonkwang University Hospital, Wonkwang University School of Medicine)
Na, Young Cheon (Department of Plastic and Reconstructive Surgery, Wonkwang University Hospital, Wonkwang University School of Medicine)
Suh, Bum Sin (Department of Plastic and Reconstructive Surgery, Wonkwang University Hospital, Wonkwang University School of Medicine)
Kim, Hyeon A (Department of Plastic and Reconstructive Surgery, Wonkwang University Hospital, Wonkwang University School of Medicine)
Heo, Woo Hoe (Department of Plastic and Reconstructive Surgery, Wonkwang University Hospital, Wonkwang University School of Medicine)
Choi, Gum Ha (Department of Pathology, Wonkwang University Hospital, Wonkwang University School of Medicine)
Lee, Seo Ul (Wonkwang Institute of Clinical Medicine)
Publication Information
Archives of Plastic Surgery / v.40, no.6, 2013 , pp. 697-704 More about this Journal
Abstract
Background We conducted an experimental study to compare the effect of massage using topical agents (Kelo-cote or Contractubex) on scar formation by massaging the healed burn wound on the dorsal area of Sprague-Dawley (SD) rats. Methods Four areas of second degree contact burn were made on the dorsal area of each of 15 SD rats, using a soldering iron 15 mm in diameter. After gross epithelialization in the defect, 15 SD rats were randomly divided into four groups: the Kelo-cote group, Contractubex group, Vaseline group, and control group. Rats in three of the groups (all but the Control group) were massaged twice per day for 5 minutes each day, while those in the Control group were left unattended. For histologic analysis, we performed a biopsy and evaluated the thickness of scar tissue. Results In the Kelo-cote and Contractubex groups, scar tissue thicknesses showed a significant decrease, compared with the Vaseline and control groups. However, no significant differences were observed between the Kelo-cote and Contractubex groups. In the Vaseline group, scar tissue thicknesses showed a significant decrease, compared with the control groups. Conclusions The findings of this study suggest that massage using a topical agent is helpful in the prevention of scar formation and that massage only with lubricant (no use of a topical agent) also has a considerable effect, although not as much as the use of a topical agent. Thus, we recommend massage with a topical agent on the post-burn scar as an effective method for decreasing the scar thickness.
Keywords
Burns; Cicatrix, hypertrophic; Wound healing; Massage;
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