Browse > Article

Orthognathic surgery in a patient with Factor VII deficiency: A Case Report  

Baek, Rong Min (Department of Plastic Surgery Seoul National University Bundang Hospital)
Oh, Myung June (Department of Plastic Surgery Seoul National University Bundang Hospital)
Lee, Sang Woo (Department of Plastic Surgery Seoul National University Bundang Hospital)
Publication Information
Archives of Plastic Surgery / v.36, no.1, 2009 , pp. 93-95 More about this Journal
Abstract
Purpose: Congenital factor VII (FVII) deficiency is a rare bleeding disorder and surgery can cause excessive bleeding due to an extrinsic pathway problem. It can be diagnosed by increased PT and decreased FVII level in coagulation test. Symptom varies according to the level of FVII, but it is essential to prevent intraoperative excessive bleeding. Methods: In this report, we described the orthognatic surgery experience in a mandibular prognathism patient with congenital FVII deficiency, in which recombinant activated factor VII (rFVIIa) was used to manage the bleeding. Rsults: We could get a successful result without any complication and there was minimal intraoperative bleeding. Conclusion: The orthognathic surgery could therefore be safely performed in patients with congenital factor VII deficiency using rFVIIa.
Keywords
Citations & Related Records
연도 인용수 순위
  • Reference
1 Aldouri M: The use of recombinant factor VIIa in controlling surgical bleeding in non-haemophiliac patients. Pathophysiol Haemost Thromb 32: 41, 2002   DOI   ScienceOn
2 O'Connell NM, Perry DJ, Hodgson AJ, O'Shaughnessy DF, Laffan MA, Smith OP: Recombinant FVIIa in the management of uncontrolled hemorrhage. Transfusion 43: 1711, 2003   DOI   ScienceOn
3 Hunault M, Bauer KA: Recombinant factor VIIa for the treatment of congenital factor VII deficiency. Semin Thromb Hemost 26: 401, 2000   DOI   PUBMED   ScienceOn
4 Tcheng WY, Donkin J, Konzal S, Wong WY: Recombinant factor VIIa prophylaxis in a patient with severe congenital factor VII deficiency. Haemophilia 10: 295, 2004   DOI   ScienceOn
5 Lanigan DT: Vascular complications associated with orthognathic surgery. Oral Maxillofac Surg Clin North Am 9: 231, 1997
6 Ragni MV, Lewis JH, Spero JA, Hasiba U: Factor VII deficiency. Am J Hematol 10: 79, 1981   DOI   ScienceOn
7 Grounds M: Recombinant factor VIIa(rFVIIa) and its use in severe bleeding in surgery and trauma: a review. Blood Rev 17: S11, 2003   DOI   PUBMED   ScienceOn
8 Mariani G, Herrmann FH, Dolce A, Batorova A, Etro D, Peyvandi F, Wulff K, Schved JF, Auerswald G, Ingerslev J, Bernardi F; International factor VII Deficiency study Group: Clinical phenotypes and factor VII genotype in congenital factor VII deficiency. Thromb Haemost 93: 481, 2005