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http://dx.doi.org/10.1007/s43188-021-00104-2

Metal arsenic mediated enhancement of type-2 immunity in brains with altered locomotive activities in mice with autism-like behavioral characteristics  

Han, Ha‑Jung (College of Bio and Medical Sciences, Department of Occupational Health, Daegu Catholic University)
Lee, JaeHee (College of Bio and Medical Sciences, Department of Occupational Health, Daegu Catholic University)
Lim, GyeongDong (College of Bio and Medical Sciences, Department of Occupational Health, Daegu Catholic University)
Park, JungEun (College of Bio and Medical Sciences, Department of Occupational Health, Daegu Catholic University)
Gautam, Ravi (College of Bio and Medical Sciences, Department of Occupational Health, Daegu Catholic University)
Jo, JiHun (College of Bio and Medical Sciences, Department of Occupational Health, Daegu Catholic University)
Kim, ChangYul (Graduate School Department of Toxicology, Daegu Catholic University)
Heo, Yong (College of Bio and Medical Sciences, Department of Occupational Health, Daegu Catholic University)
Publication Information
Toxicological Research / v.38, no.1, 2022 , pp. 27-33 More about this Journal
Abstract
Exposure to metal arsenic (As) has been proposed as a risk factor for autism spectrum disorders (ASDs), which are neurode-velopmental disorders with worldwide increasing in its incidence. In the present study, BTBR T+tf/J (BTBR) mice with ASD-like behavioral characteristics and control highly social FVB mice were orally exposed to 0.1 mM arsenic(III)oxide for 4 weeks, and were compared to investigate neuroimmunological or behavioral abnormalities. IgG1:IgG2a ratios in brain tissues from BTBR mice exposed to As (BTBR-As) were signifcantly higher than those of BTBR-control mice (BTBR-C), but this change did not occur in FVB mice exposed to As. Levels of IL-4, IFN-γ, IL-1β, IL-17, and TNF-α in brain tissue were lowered in BTBR-As relative to BTBR-C, but this tendency was not observed with FVB mice. BTBR-As mice demonstrated decrease in relative travel distance and time spent in the center vs. the periphery of open feld arena compared to BTBR-C. Sociability evaluation using three-way chamber test did not clearly demonstrate As-mediated alteration in social interaction in BTBR mice. These fndings suggest the potential for As-driven predominant TH2-like reactivity profle in the brain microenvironment of BTBR mice and for As-mediated locomotive impairment probably associated with ASD.
Keywords
Autism spectrum disorder; Postnatal mice; Metal arsenic; Brain immunotoxicity;
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