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http://dx.doi.org/10.5487/TR.2019.35.1.065

Subchronic and Reproductive/Developmental Toxicity Studies of Tetrahydrocurcumin in Rats  

Majeed, Muhammed (Sami Labs Limited)
Natarajan, Sankaran (Sami Labs Limited)
Pandey, Anjali (Sami Labs Limited)
Bani, Sarang (Sami Labs Limited)
Mundkur, Lakshmi (Sami Labs Limited)
Publication Information
Toxicological Research / v.35, no.1, 2019 , pp. 65-74 More about this Journal
Abstract
Tetrahydrocurcumin (THC) is a major metabolite of curcumin, which is obtained from Curcuma longa. THC has various benefits and overcomes the bioavailability issue of curcumin. To establish it as a pharmacologically active molecule, its safety profile has to be determined. Thus, the present study aimed to determine the preclinical safety profile of THC in a 90-day subchronic and reproductive/developmental toxicity study in Wistar rats. THC at oral doses of 100, 200, and 400 mg/kg was administered daily for 90 days. Rats in the recovery group were kept for 14 days after treatment termination. The animals were observed for treatment-related morbidity, mortality, and changes in clinical signs, clinical pathology, and histopathology. In the reproductive/developmental toxicity study, THC at 100, 200, and 400 mg/kg was administered orally to rats and the reproductive/developmental parameters in adult male and female rats and pups were observed. THC at up to 400 mg/kg/day of did not have any significant effect on all parameters in male and female rats in both toxicity studies. Thus, 400 mg/kg/day can be considered as the no-observed-adverse-effect-level of THC in rats.
Keywords
Tetrahydrocurcumin; Toxicity; Subchronic; Reproductive/developmental;
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