Browse > Article

Antitumor Activities to Cytotoxicity of Phellinus linteus Ethanol Extract  

한기원 (성균관대학교 식품생명자원학과)
이수원 (성균관대학교 식품생명자원학과)
한광수 (대한자생식품)
이대진 (허니머쉬 연구소)
이병의 ((주)오스코텍, 단국대학교 첨단과학대학)
장원철 (단국대학교)
Publication Information
Toxicological Research / v.19, no.2, 2003 , pp. 147-152 More about this Journal
Abstract
We investigated antitumor activities of the ethanol extract from mushroom Phellinus linteus and Phellinus baumii on mulberry, oak and elm. in vitro test, the ethanol extract of mushroom cultivated on oak of Phellinus linteus showed highest activities about SK-OV-3, HCT15, XF498, SK-MEL-2 and A549. SK-OV-3 cell line showed 100% cytotoxicity in 100 $\mu\textrm{g}$/ml and HCT15 (98.39%), XF498 (89.62%), SK-MEL-2 (84.07%) and A549 (79.92%) cytotoxicity respectively. Also $IC_{50}$ showed 3.99 $\mu\textrm{g}$/ml to SK-OV-3 cell line and HCT15 (4.37 $\mu\textrm{g}$/ml), A549 (5.48 $\mu\textrm{g}$/ml), SK-MEL-2 (6.72 $\mu\textrm{g}$/ml), XF 498 (6.88 $\mu\textrm{g}$/ml). As those results, cultivated oak of Phellinus linteus showed a very low $IC_{50}$ value against SK-OV-3, HCT15, XF498, SK-MEL-2 and A549 cancer cell lines.
Keywords
Phellinus linteus; Phellinus baumii; Cytotoxicity;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
연도 인용수 순위
1 Antitumor activity of aquous extract of some edible mushrooms /
[ Ikegawa,T.;Uehara,N.;Maeda,Y.;Nakanishi,M.;Fukioka,F. ] / Cancer Res.
2 Immunostimulating activity of Phellinus linteus extracts to B-lymphocyte /
[ Oh,G.T.;Han,S.B.;Kim,H.M.;Han,M.W.;Yoo,I.D. ] / Arch. Pharm. Res.   과학기술학회마을   DOI
3 Compositiomal sugar analysis of antitumor polysaccharides by high performance liqiud chromatography and gas chromatography /
[ Kim,Y.S.;Park,K.S.;Park,H.K.;Kim,S.W. ] / Arch. Pharmacal Res.   과학기술학회마을   DOI
4 Immuno-stimulating Polysacharides from the Fruiting Bodies of Fomitella fraxinea(I) /
[ Cho,S.M.;Lee,J.H.;Han,S.B.;Kim,H.M.;Yu,S.H.;Yoo,I.D. ] / Kor. J. Mycol.
5 New colorimetric cytotoxicity assay for anticancerdrug screening /
[ Skehan,P.;Storeng,R.;Scudiero,D.;Monk,A.;McMahon,J.D.;Vista,J.;Warren,T.;Kenney,S.;Boyd,M.R. ] / J. Natl. Cancer lnst.   DOI
6 Host-mediated antitumor action of schizophyllan,a glucan produced by Schizophyllum commune /
[ Komatsu,N.;Okuba,S.;Likumoto,S.;Kimura,K.;Saito,G.;Sakaki,S. ] / Gann
7 Evaluation of colorimetric protein and bidmass strains for assaying in vitro drug effects upon human tumor cell lines /
[ Skehan,P.;Storeng,R.;Scuderio,N.;Boyd,M. ] / Proceedings of the American Assodiation for Cancer Research
8 Antitumor activity of kp,a Protein-polysaccharide from mycelial culture of Phellinus linteus /
[ Chung,K.S.;Kim,S.S.;Kim.H.S.;Han,M.W.;Kim,B.K. ] / Yakhak Hoechi
9 Effect of Cultural Conditions on Polysaccharides Production and its Monosaccharide Composition in Phellinus L13202 /
[ Lee,J.H.;Cho,S.M.;Ko,K.S.;Yoo,I.D. ] / Kor. J. Mycol.   과학기술학회마을
10 Antitumor polysaccharides from some Polyporaceae, Ganoderma applanatum (Pers) Pat and Phellinus linteus (Berk. et Curt) Aoshima /
[ Sasaki,T.; Arai,Y.;Ikekawa,T.;Chihara,G.;Fukuoka,F. ] / Chem. Pharm. Bull.   DOI
11 Characterization of carbohydrate-peptide linkage of acidic hetero-glycopeptide with immuno-stimulating activity from mycelium of Phellinus linteus /
[ Lee,J.H.;Cho,S.M.;Song,K.S.;Hong,N.D.;Yoo,I.D. ] / Chem. Pharm. Bull.   DOI
12 lmmuno-stimulating Activity of Phellinus linteus /
[ Song,C.H.;Ra,K.S.;Yang,B.K.;Jeon,Y.J. ] / Kor. J. Mycol.
13 Correlation of screening data generated with a tetrazolium assay (MTT) versus a protein assay (SRB) against a broad panel of human tumor cell lines /
[ Rubinstein,L.V.;Paull,K.D.;Shoemaker,R.H.;Simon,R.M.;Skehan,P.;Boyd,M.R. ] / Proceeding of the American Association for Cancer Research
14 Antitumor and lmmunomodulatory Activities of Mushroom (Phellinus linteus) cultured on Oak and Mulberry /
[ Kim,Y.S.;Lee,B.E.;Cho,K.B.;Lee,Y.T.;Lee,D.J. ] / Kor. J. lmmunol.
15 Protein-bound polysaccharide preparation, PS-K, effective against mouse sarcoma-180 and rat ascites hepatoma AH-13 by oral use /
[ Tsugagoshi,S.;Ohashi,F. ] / Gann
16 B-lymphocyte-stimulating polysaccharide from Mushroom Phellinus linteus /
[ Song,K.S.;Cho,S.M.;Lee,J.H.;Kim,H.M.;Han,S.B.;Ko,K.S.;Yoo,I.D. ] / Chem. Pharm. Bull.   DOI
17 Fractionation of the polysaccharides with marked antitumor activity, especially lentinan from Lentinus edodes (Berk) Sing. (an edible mushroom) /
[ Chihara,G.;Hamuro,J.;Maeda,Y.;Arai,Y.;Fukuoka,F. ] / Cancer Res.
18 Effect of Kp, an antitumor protein polysaccharide from mycelial culture of Phellinus linteus on the humoral immune response of tumor-bearing ICR mice to sheep Red Blood Cells /
[ Chung,K.S.;Kim,S.S.;Kim,H.S.;Kim,K.Y.;Han,M.W.;Kim,K.H. ] / Arch. Pharm. Res.   과학기술학회마을   DOI