Browse > Article
http://dx.doi.org/10.15188/kjopp.2020.12.34.6.319

Studies on Anti-inflammatory Effects of Mahwanghangingamchosukgo-tang Extracts  

Park, Jung Eun (School of Cosmetic Science and Beauty Biotechnology, Semyung University)
Hwang, Hyung Seo (School of Cosmetic Science and Beauty Biotechnology, Semyung University)
Kim, Tae Yeon (College of Korean Medicine, Semyung University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.34, no.6, 2020 , pp. 319-325 More about this Journal
Abstract
Mahwanghangingamchosukgo-tang (MH) is recorded as a treatment to treat exterior-related respiratory diseases in the Korean medicine. In this study, we examined the anti-inflammatory effects of MH, using MH water extract and lipopolysaccharide (LPS)-induced RAW 264.7 cells. First of all, we measured the amount of nitric oxide (NO) and prostaglandin E2 (PGE2), the products of inflammatory metabolism. Also, we measured enzymes such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), as well as cytokines such as interleukin 6 (IL-6), interleukin 1 alpha (IL-1α), and interleukin 1 beta (IL-1β). MH suppressed the production of NO and PGE2 in a dose dependent manner and reduced the amount of protein and the mRNA expression of iNOS and COX-2. Also, MH reduced the mRNA expression of IL-6, IL-1α and IL-1β. In conclusion, MH decreased production of LPS-induced inflammatory factor, which could be a clinical basic subject for inflammatory diseases.
Keywords
Mahwanghangingamchosukgo-tang (MH)(麻 黃 杏 仁 甘 草 石 膏 湯 ); Anti-inflammatory; Inflammatory factor; NO; $PGE_2$;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
연도 인용수 순위
1 Vinay K, Abul A, Nelson F, Jon A. Robbins & Cotran Pathologic Basis of disease. 8th ed. Amsterdam:Elsevier Inc;2011. p. 69.
2 Jang JT, Seo IB, Kim JB. Effects of Gamimahaenggamseok-tang and Typhae Pollen on Body Weight and Lipid Metabolism of Rats with Obesity induced by High Fat Diets. Korean J. Oriental Physiology & Phathology. 2003;17(1):190-202.
3 Cho JH. Effect of Mahaenggamseok-Tang(Mahuangjiazhu-tang) on Anti-Obesity in High Fat Diet-induced Obese Sprague-Dawley Rat. Naju:Dongshin University;2011. p. 42.
4 Noh HM, Park SG, Kweon SH, Jo EH, Park MC. Case Report of the Patient with the Atopic Dermatitis, Psoriasis Treated with Mahaenggamseog-tang. 2018;32(1):80-7.   DOI
5 Textbook Compilation Committee of Herbal Pharmacology. Herbal Pharmacology. 3rd ed. Seoul:Sinil books;2010. p. 116-7, 182-4, 273-7, 328-30.
6 Yeom MJ, Lee HC, Kim GH, Lee HJ, Shim IS, Oh SK, Kang SK, Hahm DH. Anti-arthritic Effects of Ephedra sinica STAPF Herb-Acupuncture: Inhibition of Lipopolysaccharide-Induced Inflammation and Adjuvant-Induced Polyarthritis. J Pharmacol Sci. 2006;100(1):41-50.   DOI
7 DO JS. Hwang JK, Seo HJ, Woo WH, Nam SY. Antiasthmatic activity and selective inhibition of type 2 helper T cell response by aqueous extract of semen armeniacae amarum. Immunopharmacol Immunotoxicol. 2006;28(2):213-38.   DOI
8 Yang HY, Chang HK, Lee JW, Kim YS, Kim H, Lee MH, Shin HS, Ham DH, Park HK, Lee HJ, Kim CJ. Amygdalin suppresses lipopolysaccharide-induced expressions of cyclooxygenase-2 and inducible nitric oxide synthase in mouse BV2 microglial cells. Neurol Res. 2007;29(1):59-64.   DOI
9 Zhu YP. Chinese Materia Medica Chemistry, Pharmacology and applications. The Netherlands: Harwood Academic Publishers;1998. p. 496-8.
10 Fukai T, Satoh K, Nomura T, Sakagami H. Preliminary evaluation of antinephritis and radical scavenging activities of glabridin from Glycyrrhiza glabra. 2003;74(7):624-9.   DOI
11 Dawson TM, Dawson VL, Snyder SH. A novel neuronal messenger molecule in brain:The free radical, nitric oxide. Ann Neurol. 1992;32:297-311.   DOI
12 Masayasu K. Herbal Pharmacology. Tokyo:Namsandang ;1997. p. 132-3.
13 Kindt TJ, Goldsby RA, Osborne BA. Innate immunity : Tenney S. Kuby Immunology. 6th ed. New York:Freeman press;2007. p. 52-73.
14 Kim BH, Lee YT, Kang KH. Codonopsis Lanceolata Inhibits Inflammation through Regulation of MAPK in LPS-stimulated RAW264.7 cells. J Physiol Pathol Korean Med. 2010;24(1):80-4.
15 Wang MJ, Lin WW, Chen HL, Chang YH, Ou HC, Kuo JS, et al. Silymarin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity by inhibiting microglia activation. Eur J Neurosci. 2002;16(11):2103-12.   DOI
16 Hanisch UK. Microglia as a source and target of cytokines. Glia. 2002;40(2):140-55.   DOI
17 Chen W, Tang Q, Gonzales MS, Bowden GT. Role of p38 MAP kinases and ERK in mediating ultraviolet-B induced cyclooxygenase-2 gene expression in human keratinocytes. Oncogene. 2001;20(29):3921-6.   DOI
18 Marina L, Kamal RM, Andrew F, Gary B, Jeremy S, Andrew RC. Regulation of Cyclooxygenase 2 mRNA Stability by the Mitogen-Activated Protein Kinase p38 Signaling Cascade. Mol Cell Biol. 2000;20(12):4265-74.   DOI
19 Mitchell JA, Larkin S, Williams TJ. Cyclooxygenase-2 :regulation and relevance in inflammation. Biochemical Pharmacology. 1995;50(10):1535-42.   DOI
20 Saeedi M, Morteza-Semnani K, Ghoreishi MR. The treatment of atopic dermatitis with licorice gel. 2003;14(3):153-60.
21 Amagaya S, Sugishita E, Ogihara Y, Ogawa S, Okada K, Aizawa T. Comparative studies of the stereoisomers of glycyrrhetinic acid on anti-inflammatory activities. J Pharmacobiodyn. 1984;7(12):923-8.   DOI
22 National College of Korean Medicine Collaborative Textbook Compilation Committee. Herbology. Seoul:Younglim Publishing Inc;2000. p. 121, 160, 478, 540.
23 Crofford LJ, Lipsky PE, Brooks P, Abramson SB, Simon LS, Van de Putte LB. Basic biology and clinical application of specific cyclooxygenase-2 inhibitors. Arthritis Rheum. 2000;43(1):4-13.   DOI
24 Raabe T, Bukrinsky M, Currie RA. Relative contribution of transcription and translation to the induction of tumor necrosis factor-alpha by lipopolysaccharide. J Biol Chem. 1998;273(2):974-80.   DOI
25 Choi BG. Free radicals and diseases. Seoul:Shinil books;2004. p. 214.
26 Textbook Compilation Committee of Pathology in Korean Medicine. Pathology in Korean Medicine. Yongin:Hanuimunhwasa;2019. p. 41-3, 64, 66, 440.
27 Moon JJ, An GS, Kim JB, Park WS, Park JH, Kim DH et al. Precise Interpretation of 'Treatise on Cold Damage Diseases'. Yongin:Hanuimunhwasa;2014. p. 162-4, 338-9.
28 Lee JG, Koo YS, Lee YG, Park YC. Effect of Mahaenggamseok-tang-gagambang on CD3, CD4, CD8 Cells in OVA-induced Asthmatic Mice. Journal of Oriental Medicine Research Institute in Daejeon University. 2008;17(1):67-74.
29 Hong ND, Jeong GM, Moon JH, Joo SM. Effects of Mahaengkamsuk-tang on Analgesic, Antipyretic, Antiinflammatory, Secretion of Respiratory Tract, Isolated Ileum and Blood Pressure. Kor. J. Pharmacogn. 1986;17(3):223-32.
30 Lee JH, Jung SG, Rhee HK. Effect of Mahwanghangingamchosukgo tang & Mahwanghangingamchosukgotang gamibang on the Pulmonary Function of SO2-Exposed Rats. K. H. Univ. O Med. J. 1993;16:85-105.
31 Park GB, Park YC. Effects of Mahaenggamseok-tang-gagambang on Immune Cells and Cytokines in OVA-Induced Asthmatic Mice. Korean J. Oriental Physiology & Phathology. 2009;23(3):590-8.
32 Park SH, Jeong HJ, Jeong SG, Lee HG. The Inhibitory Effects Mahaenggamseok-Tang and Platycodi Radix on the Cytokines of Human Epitherial Cells. K. H. M. 2001;17(2);230-41.
33 Lee YB, Jeong AR. Mahaenggamsuktang for treating Mycoplasma pneumonia in Children: Systematic Review and Meta-analysis of Randomized Controlled Trials (RCTs). J Pediatr Korean Med. 2020;34(2):86-104.