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http://dx.doi.org/10.15188/kjopp.2018.02.32.1.43

Effect of Korean Red Ginseng on Hypertriglyceridemia in High Fat/high Cholesterol Diet Rat Model  

Kim, Hye Yoom (College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University)
Jin, Xian Jun (College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University)
Hong, Mi Hyeon (College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University)
Ko, Seon Mi (Institute of Jinan Red Ginseng)
Hwang, Seung Mi (Institute of Jinan Red Ginseng)
Im, Dong joong (Institute of Jinan Red Ginseng)
Ahn, You Mee (College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee, Ho Sub (College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University)
Kang, Dae Gill (College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee, Yun Jung (College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.32, no.1, 2018 , pp. 43-50 More about this Journal
Abstract
Korean Red Ginseng (RG) are used as a traditional treatment for improve blood circulation. This experimental study was designed to investigate the inhibitory effects of Korean red ginseng on lipid metabolism in high fat/cholesterol diet (HFCD)-induced hypertriglyceridemia. Sprague Dawley rats were fed the HFCD diet with/without fluvastatin (Flu, positive control) 3 mg/kg/day, and RG 125 or 250 mg/kg/day, respectively. All groups received regular diet or HFCD diet, respectively, for 13 weeks. The last three groups treatment of Flu and RG 125, and RG 250 orally for a period of 9 weeks. Group 1, reular diet; group 2, HFCD diet; group 3, Flu + HFCD diet; group 4, RG 125 + HFCD diet; group 5, RG 250 + HFCD diet. As a result, treatment with low or high doses of RG markedly attenuated plasma levels of triglycerides and augmented plasma levels of high-density lipoprotein (HDL) in HFCD-fed rats. RG and Flu also led to an increase in lipoprotein lipase activity in the HFCD group. On the other hand, RG and Flu led to an decrease in fatty acid synthase and free fatty acid activity in the HFCD group. Treatment with RG suppressed increased expressions of $PPAR-{\alpha}$ and AMPK in HFCD rat liver or muscle. In addition, the RG attenuated triglyceridemia by inhibition of $PPAR-{\gamma}$ and FABP protein expression levels and LXR and SREBP-1 gene expression in liver or muscle. The RG significantly prevented the development of the metabolic disturbances such as hypertriglyceridemia and hyperlipidemia. Taken together, the administration of RG improves hypertriglyceridemia through the alteration in suppression of triglyceride synthesis and accentuated of triglyceride decomposition. These results suggested that RG is useful in the prevention or treatment of hypertriglyceridemia.
Keywords
Korean Red Ginseng; Triglyceride; Hypertriglyceridemia; Triglyceride synthesis; Metabolism;
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