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http://dx.doi.org/10.15188/kjopp.2017.08.31.4.226

Melanogenic Effect and the Mechanism of Epimedium koreanum Nakai  

Cha, Su Bin (Department of Herbal Resources, Professional Graduate School of Korean Medicine, Wonkwang University)
Kim, Dan Hee (Department of Herbal Resources, Professional Graduate School of Korean Medicine, Wonkwang University)
Mun, Yeun Ja (Department of Herbal Resources, Professional Graduate School of Korean Medicine, Wonkwang University)
Woo, Won Hong (Department of Anatomy, College of Korean Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.31, no.4, 2017 , pp. 226-232 More about this Journal
Abstract
In this study, ethanol extract of Epimedium koreanum Nakai(EEKN) enhanced melanogenesis by inducing expression of tyrosinase and tyrosinase-related protein-1 (TRP-1). But EEKN did not increase the protein expression of tyrosinase-related protein 2 (TRP-2). Moreover, EEKN enhanced tyrosinase activity and melanin contents of B16F10 cells. EEKN raised the expression of CREB phosphorylation and microphthalmia-associated transcription factor (MITF) as a key transcription factor for tyrosinase expression regulating melanogenesis. And PKC inhibitor H89 supressed that EEKN induced tyrosinase activity, melanin contents, and expression of tyrosinase, TRP-1. These results suggest that melanogenesis-promoting effect of EEKN was correlated with regulation of tyrosinase and TRP-1 protein through cAMP/PKC pathway.
Keywords
Epimedium koreanum Nakai; Melanogenesis; cAMP/PKC pathway;
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Times Cited By KSCI : 11  (Citation Analysis)
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