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http://dx.doi.org/10.15188/kjopp.2016.10.30.5.314

Effect of Benincasa hispida Extract on Mucus Secretion in Rat Tracheobronchial Lumen  

Kang, Young Kook (Department of Fusion Science Education, College of Hyehwa Liberal Arts, Daejeon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.30, no.5, 2016 , pp. 314-319 More about this Journal
Abstract
Mucus in the respiratory system is a factor to cause not only respiratory diseases but also chronic diseases. In this regard, this study is to investigate whether Benincasa hispida extracts (BHE) would stimulate secreting mucus in trachea and tracheobronchial lumen of rats. As a result, effect of stimulating the mucus secretion into trachea and trachebronchial lumen of rats is significantly increased in accordance with the administration concentration of Benincasa hispida seed extracts (BHSE). The secretion amounts of phenol red (PR) and sodium fluoreseceine (NaFI) are significantly increased by 25% and 34%, respectively, when 70% EtOH extracts of Benincasae pericarpium (BPE) are administrated to rats at the concentration of 200 mg/kg. In addition, the secretion amounts of PR and NaFI are significantly increased when BuOH fraction and water fraction are intraperitoneally administrated to rats at the concentration of 200 mg/kg. It seems the result implies the physiologically active substance that stimulates the secretion of mucus is contained in Benincasa hispida. Thus, Benincasa hispida is considered to be effective for Korean medicine treatment as a medicinal plant having effect of antitussive and apophlegmatic, and it also can be useful in developing functional food and beverage.
Keywords
Antitussive; Benincasa hispida; Benincasae pericarpium; Mucus;
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1 Newhouse, M.T. and Biennenstock, J. Respiratory tract defense mechanism, in textbook of pulmonary disease. Baum, G.L. and Wolinsky, E. 3rd ed., Little Brown and Company, 1983.
2 Hilding, A.C. Ciliary streaming in the bronchial tree and the time element in carcinogenesis. N Engl J Med 256(14):634-640, 1957.   DOI
3 Yoon, J.H. Control of mucus secretion by airway epithelium. Allergy 17(3):201-212, 1997.
4 Kim, S.Y., Moon, J.Y., Lee, D.W. Park, K.H. Study on the expectorant activity of ethanol extracts from some crude drug containing saponins. Kor J Pharmacogn 19(2):133-140, 1988.
5 Gunnarsson, M., Hybbinette, J.C., Mercke, U. Mucolytic agents and mucociliary activity. Rhinology 22: 223-231, 1984.
6 Coppi, G. and Gatti, M.T. A method for studying expectorant action in the mouse by measurement of tracheobronchial phenol red secretion. Famaco 44(5):541-545, 1989.
7 Chand, N., Harrison, J.E., Rooney, S., Diamantis, W., Sofia, R.D. Mucolytic activity of azelastine in mice and rats. Agents Actions 38(3-4):165-170, 1993.   DOI
8 Liu, W., Wang, Y., He, D.D., Li, S.P., Zhu, Y.D., Jiang, B., Cheng, X.M., Wang, Z., Wang, C.H. Antitussive, expectorant, and bronchodilating effects of quinazoline alkaloids (±)-vasicine, deoxyvasicine and (±)-vasicinone from aerial parts of Peganum harmala L. Phytomedicine 22(12):1088-1095, 2005.   DOI
9 Liu, W., Cheng, X., Wang, Y., Li, S., Zheng, T., Gao, Y., Wang, G., Qi, S., Wang. J., Ni, J., Wang, Z., Wang, C. In vivo evaluation of the antitussive, expectorant and bronchodilating effects of extract and fractions from aerial parts of Peganum harmala linn. J Ethnopharmacol 162: 79-86, 2015.   DOI
10 Wang, D., Wang, S., Chen, X., Xu, X., Zhu, J., Nie, L., Long, X. Antitussive, expectorant and anti-inflammatory activities of four alkaloids isolated from bulbus of Fritillaria wabuensis. J Ethnopharmacol 139(1):189-193, 2012.   DOI
11 Lim, S.J., Kim, H.R. Effects of Benincasa hispida seeds intake on blood glucose and lipid levels in streptozotocin induced diabetic rats. J Nutrition and Health 37(4):259-265, 2004.
12 Lim, S.J., Lee, M.H. Effects of fractions of Benincasa hispida on plasma levels of glucose and lipid in streptozotocin induced diabetic rats. J Nutrition and Health 38(10):801-806, 2005.
13 Lin, B.Q., Li, P.B., Wang, Y.G., Peng, W., Wu, Z., Su, W.W., Ji, H. The expectorant activity of naringenin. Pulm Pharmacol Ther 21(2):259-263, 2008.   DOI
14 Ge, Y., Liu, J., Su, D. In vivo evaluation of the anti-asthmatic, antitussive and expectorant activities of extract and fractions from Elaeagnus pungens leaf. J Ethnopharmacol 126(3):538-542, 2009.   DOI
15 Zhou, Q., Liang, D., Deng, A., Zhang, J., Wu, C., Nie, Z., Jiang, J., Wang, Y. Antitussive, expectorant and bronchodilating effects of ethanol extract of Sorghum bicolor (L.) moench roots. J Ethnopharmacol 149(1):297-302, 2013.   DOI
16 Song, K.J., Shin, Y.J., Lee, K.R., Lee, E.J., Suh, Y.S., Kim, K.S. Expectorant and antitussive effect of Hedera helix and Rhizoma coptidis extracts mixture. Yonsei Med J 56(3):819-824, 2015.   DOI
17 Jiang, K., Song, Q., Wang, L., Xie, T., Wu, X., Wang, P., Yin, G., Ye, W., Wang. T. Antitussive, expectorant and anti-inflammatory activities of different extracts from exocarpium Citri grandis. J Ethnopharmacol 156: 97-101, 2014.   DOI
18 Moon, C.J. Coloured illustration for discrimination of herbal medicine Ⅳ. Korea Food & Drug Administration p 38, 2006.
19 Lim, S.J., Jeong, J.G., Kim, M.W., Choi, S.S., Han, H.K., Park, J.E. Effects of Benincasa hispida intake on blood glucose and lipid level in streptozotocin induced diabetic rats. J Nutrition and Health 36(4):335-343, 2003.
20 Lim, S.J., Jeong, J.G., Kim, M.W., Choi, S.S., Han, H.K., Park, J.E. Effects of Benincasa hispida intake on blood glucose and lipid level in streptozotocin induced diabetic rats. J Nutrition and Health 36(4):335-343, 2003.
21 You, Y.H., Jun, W.J. Effects of fractions from Benincasa hispida on inhibition of adipogenesis in 3T3-L1 preadipocytes. J Korean Soc Food and Nutr 41(7):895-900, 2012.   DOI
22 Lim, S.J. Effects of fractions of Benincasa hispida on antioxidative status in streptozotocin induced diabetic rats. J Nutrition and Health 40(4):295-302, 2007.
23 Lim, S.J., Lee, M.H. Effects of Benincasa hispida fractions on hepatic lipid levels and lipid peroxidation in streptozotocin induced diabetic rats. J Nutrition and Health 39(6):513-519, 2006.
24 Nandecha, C., Nahata, A., Dixit, V.K. Effect of Benincasa hispida fruits on testosterone-induced prostatic hypertrophy in albino rats. Curr Ther Res Clin Exp 71(5):331-343, 2010.   DOI
25 Engler, H., Szelenyi, I. Tracheal phenol red secretion, a new method for screening mucosecretolytic compounds. J Pharmacol Methods 11(3):151-157, 1984.   DOI
26 Kase, Y., Hidaka, T., Miyata, T., Takahama, K., Okano, Y., Kubo, S., Yamazaki, M. Pharmacological effects of brovanexine hydrochloride (BR-222) on the respiratory tract system, particularly on the respiratory tract fluid, mucociliary transport and cough. Nihon Yakurigaku Zasshi 83(2):173-181, 1984.   DOI
27 Ann, Y.G., Shin, S.C., Kim, S.K., Shin, C.S. Studies on wax gourd wine. Korean J Food Nutr 13(6):578-584, 2000.
28 Ann, Y.G., Kim, S.K., Shin, C.S. Studies on wax gourd-ginseng vinegar. Korean J Food Nutr 14(1):52-58, 2001.
29 Walker, N.J., Tritscher, A.M., Sills, R.C., Lucier, G.W., Portier, C.J. Hepatocarcinogenesis in female Sprague-Dawley rats following discontinuous treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 54(2):330-337, 2000.   DOI
30 Van Birgelen, A.P.J.M., Hebert, C.D., Wenk, M.L., Grimes, L.K., Chapin, R.E., Mahler, J., Travlos, G.S., Bucher, J.R. Toxicity of 3,3,4,4-tetrachloroazobenzene in rats and mice. Toxicol and Appl Pharmacol 156(2):147-159, 1999.   DOI
31 Guo, T., Qing Wei, J., Ping Ma, J. Antitussive and expectorant activities of Potentilla anserina. Pharm Biol 54(5):807-811, 2016.   DOI
32 Kang, Y.K., Lim, H.B., Sohn, H.O., Lee, Y.G., Nam, S.H., Lee, D.W. Effects of silkworm-extract on mucus secretion in rat tracheobronchial lumen. Korean J Ent 30(2):71-75, 2000.
33 The encyclopedia britannica of Korea. Britannica company, 1994.
34 Ahn, Y.K. Korean and dogmeat. Hyoilmoonhwasa. pp 247-248, 2000.