Browse > Article
http://dx.doi.org/10.15188/kjopp.2016.08.30.4.219

Review on Clinical Studies of Traditional Herbal Medicine and Acupuncture Treatments for Colorectal Cancer Patients  

Kang, Yun Hwan (Department of Korean Medicine, School of Korean Medicine, Pusan National University)
Hong, Mi-na (Department of Korean Medicine, School of Korean Medicine, Pusan National University)
Han, Chang Woo (Department of Korean Medicine, School of Korean Medicine, Pusan National University)
Choi, Jun Yong (Department of Korean Medicine, School of Korean Medicine, Pusan National University)
Park, Seong Ha (Department of Korean Medicine, School of Korean Medicine, Pusan National University)
Kim, So Yeon (Department of Korean Medicine, School of Korean Medicine, Pusan National University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.30, no.4, 2016 , pp. 219-228 More about this Journal
Abstract
The aim of this study was to collect and analyze the clinical studies of traditional herbal medicine and acupuncture treatments for colorectal cancer patients searched in Pubmed and Cochrane library in English. We collected the clinical studies, including randomized controlled trial, case control study and cohort study, in the PubMed and Cochrane library using keywords 'Colorectal Cancer', 'Korean Medicine', 'Traditional Chinese Medicine', 'Kampo' and 'Acupuncture'. Then we analyzed them according to the objective of the therapy, i.e. improving therapy prognosis, reducing chemotherapy's adverse event and reducing operational adverse event. In case RCT, we evaluate the quality of the study with jadad scale. Total 18 studies were selected. There were 3 studies about improving therapy prognosis, 6 studies about reducing chemotherapy's adverse event and 9 studies about reducing operational adverse event. Traditional medicine might improve therapy prognosis in terms of the survival rate, relapse/metastasis rate, quality of life and immune function. The specific herbal formula, 'Goshajinkigan' might not be successful about reducing chemotherapy's adverse event, peripheral neurotoxicity. 'Hangeshanshinto' might reduce the duration of oral mucositis but it is not clear to reduce the incidence of that. 'PHY906' might reduce the incidence of diarrhea. Acupuncture might reduce operational adverse event such as gastrointestinal dysfunction and pain. And 'Daikenchuto' might not be successful in reducing operational adverse event, gastrointestinal dysfunction. Further studies are needed to clarify the efficacy of traditional herbal medicine and acupuncture for colorectal cancer patients.
Keywords
Colorectal Cancer; Traditional Herbal Medicine; Acupuncture; Literature Review; Clinical Study;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Gotoh, A., Goto, K., Sengoku, A., Shirakawa, T., Akao, Y., Fujisawa, M., et al. Inhibition mechanism of Gosha-jinki-gan on the micturition reflex in rats. J Pharmacol Sci 96(2):115-123, 2004.   DOI
2 Yamada, K., Suzuki, E., Nakaki, T., Watanabe, S., Kanba, S. Aconiti tuber increases plasma nitrite and nitrate levels in humans. J Ethnopharmacol 96(1-2):165-169, 2005.   DOI
3 Kase, Y., Hayakawa, T., Aburada, M., Komatsu, Y., Kamataki, T. Preventive effects of Hange-shashin-to on irinotecan hydrochloride-caused diarrhea and its relevance to the colonic prostaglandin E2 and water absorption in the rat. Jpn J Pharmacol 75(4):407-413, 1997.   DOI
4 Mori, K., Kondo, T., Kamiyama, Y., Kano, Y., Tominaga, K. Preventive effect of Kampo medicine (Hangeshashin-to) against irinotecan-induced diarrhea in advanced non-small-cell lung cancer. Cancer Chemother Pharmacol 51(5):403-406, 2003.
5 Kono, T., Kaneko, A., Matsumoto, C., Miyagi, C., Ohbuchi, K., Mizuhara, Y., et al. Multitargeted effects of hangeshashinto for treatment of chemotherapy-induced oral mucositis on inducible prostaglandin E2 production in human oral keratinocytes. Integr Cancer Ther 13(5):435-445, 2014.   DOI
6 Matsuda, C., Munemoto, Y., Mishima, H., Nagata, N., Oshiro, M., Kataoka, M., et al. Double-blind, placebo-controlled, randomized phase II study of TJ-14 (Hangeshashinto) for infusional fluorinated-pyrimidine -based colorectal cancer chemotherapy-induced oral mucositis. Cancer Chemother Pharmacol 76(1):97-103, 2015.   DOI
7 Hosokawa, A., Ogawa, K., Ando, T., Suzuki, N., Ueda, A., Kajiura, S., et al. Preventive effect of traditional Japanese medicine on neurotoxicity of FOLFOX for metastatic colorectal cancer: a multicenter retrospective study. Anticancer Res 32(7):2545-2550, 2012.
8 Kono, T., Mamiya, N., Chisato, N., Ebisawa, Y., Yamazaki, H., Watari, J., et al. Efficacy of goshajinkigan for peripheral neurotoxicity of oxaliplatin in patients with advanced or recurrent colorectal cancer. Evid Based Complement Alternat Med 2011:418481, 2011.   DOI
9 Yoshikawa, K., Shimada, M., Nishioka, M., Kurita, N., Iwata, T., Morimoto, S., et al. The effects of the Kampo medicine (Japanese herbal medicine) "Daikenchuto" on the surgical inflammatory response following laparoscopic colorectal resection. Surg Today 42(7):646-651, 2012.   DOI
10 Oki, E., Emi, Y., Kojima, H., Higashijima, J., Kato, T., Miyake, Y., et al. Preventive effect of Goshajinkigan on peripheral neurotoxicity of FOLFOX therapy (GENIUS trial): a placebo-controlled, double-blind, randomized phase III study. Int J Clin Oncol 20(4):767-775, 2015.   DOI
11 Yaegashi, M., Otsuka, K., Itabashi, T., Kimura, T., Kato, K., Fujii, H., et al. Daikenchuto stimulates colonic motility after laparoscopic-assisted colectomy. Hepatogastroenterology 61(129):85-89, 2014.
12 Suehiro, T., Matsumata, T., Shikada, Y., Sugimachi, K. The effect of the herbal medicines dai-kenchu-to and keishi-bukuryo-gan on bowel movement after colorectal surgery. Hepatogastroenterology 52(61):97-100, 2005.
13 Zhou, L.Y., Shan, Z.Z., You, J.L. Clinical observation on treatment of colonic cancer with combined treatment of chemotherapy and Chinese herbal medicine. Chin J Integr Med 15(2):107-111, 2009.   DOI
14 Salaga, M., Zatorski, H., Sobczak, M., Chen, C., Fichna, J. Chinese herbal medicines in the treatment of IBD and colorectal cancer: a review. Curr Treat Options Oncol 15(3):405-420, 2014.   DOI
15 Okumi, H., Koyama, A. Kampo medicine for palliative care in Japan. Biopsychosoc Med 8(1):6-0759-8-6, 2014.   DOI
16 McCulloch, M., Broffman, M., van der Laan, M., Hubbard, A., Kushi, L., Abrams, D.I., et al. Colon cancer survival with herbal medicine and vitamins combined with standard therapy in a whole-systems approach: ten-year follow-up data analyzed with marginal structural models and propensity score methods. Integr Cancer Ther 10(3):240-259, 2011.   DOI
17 Yang, Y.F., Ge, J.Z., Wu, Y., Xu, Y., Liang, B.Y., Luo, L, et al. Cohort study on the effect of a combined treatment of traditional Chinese medicine and Western medicine on the relapse and metastasis of 222 patients with stage II and III colorectal cancer after radical operation. Chin J Integr Med 14(4):251-256, 2008.   DOI
18 Kummar, S., Copur, M.S., Rose, M., Wadler, S., Stephenson, J., O'Rourke, M., et al. A phase I study of the chinese herbal medicine PHY906 as a modulator of irinotecan-based chemotherapy in patients with advanced colorectal cancer. Clin Colorectal Cancer 10(2):85-96, 2011.   DOI
19 Nishioka, M., Shimada, M., Kurita, N., Iwata, T., Morimoto, S., Yoshikawa, K., et al. The Kampo medicine, Goshajinkigan, prevents neuropathy in patients treated by FOLFOX regimen. Int J Clin Oncol 16(4):322-327, 2011.   DOI
20 Ng, S.S., Leung, W.W., Hon, S.S., Li, J.C., Wong, C.Y., Lee, J.F. Electroacupuncture for ileus after laparoscopic colorectal surgery: a randomised sham-controlled study. Hong Kong Med J 19 Suppl 9: 33-35, 2013.
21 Deng, G., Wong, W.D., Guillem, J., Chan, Y., Affuso, T., Yeung, K.S., et al. A phase II, randomized, controlled trial of acupuncture for reduction of Postcolectomy Ileus. Ann Surg Oncol 20(4):1164-1169, 2013.   DOI
22 Meng, Z.Q., Garcia, M.K., Chiang, J.S., Peng, H.T., Shi, Y.Q., Fu, J., et al. Electro-acupuncture to prevent prolonged postoperative ileus: a randomized clinical trial. World J Gastroenterol 16(1):104-111, 2010.
23 Katsuno, H., Maeda, K., Kaiho, T., Kunieda, K., Funahashi, K., Sakamoto, J., et al. Clinical efficacy of Daikenchuto for gastrointestinal dysfunction following colon surgery: a randomized, double-blind, multicenter, placebo-controlled study (JFMC39-0902). Jpn J Clin Oncol 45(7):650-656, 2015.   DOI
24 National Cancer Information Center. Cancer Incidence Trends. 2013; Available at: http://www.cancer.go.kr/mbs/cancer/subview.jsp?id=cancer_040104000000.
25 Yasunaga, H., Miyata, H., Horiguchi, H., Kuwabara, K., Hashimoto, H., Matsuda, S. Effect of the Japanese herbal kampo medicine dai-kenchu-to on postoperative adhesive small bowel obstruction requiring long-tube decompression: a propensity score analysis. Evid Based Complement Alternat Med 2011: 264289, 2011.   DOI
26 Zhang, Z., Wang, C., Li, Q., Zhang, M., Zhao, H., Dong, L., et al. Electroacupuncture at ST36 accelerates the recovery of gastrointestinal motility after colorectal surgery: a randomised controlled trial. Acupunct Med 32(3):223-226, 2014.   DOI
27 Zhong, L.L., Chen, H.Y., Cho, W.C., Meng, X.M., Tong, Y. The efficacy of Chinese herbal medicine as an adjunctive therapy for colorectal cancer: a systematic review and meta-analysis. Complement Ther Med 20(4):240-252, 2012.   DOI
28 Kim MH, Kang PS, Lee KS, Hwang TY, Annette M. Utilization of Complementary and Alternative Medicine of Cancer Patient in Korea. Journal of Agricultural Medicine & Community Health 32(3):155-167, 2007.   DOI
29 National Cancer Information Center. Cancer Statistics. 2013; Available at: http://www.cancer.go.kr/mbs/cancer/subview.jsp?id=cancer_040102000000.
30 Kim, J.B., Ahn, K.S. A Comparative Study between East and West Medicine on the Colorectal Cancer. J Pathol Korean Med 9(2):89-127, 1995.
31 Kim, S.M., Park, S.H., Seo, J.C., Lee, G.H., Kim, K.S. Literature review on aroma inhalation therapy using aromatic essential oils in cancer patients. The Journal of East-West Medicines 38(3):57-62, 2013.
32 Kim, S.M., Park, S.H., Seo, J.C., Lee, G.H., Kim, K.S. Literature review on qigong exercise in cancer patients focusing on Randomized Controlled Clinical Trials. The Journal of East-West Medicines 38(3):51-56, 2013.
33 Sun, S.H., Ko, S.G., Jung, Y.S., Bu, S.A., Park, K.H. A Bibliographical Study of Chinese Medical Journals regarding the Treatment of Leucopenia, Occurred after Radiotherapy and Chemotherapy Treatment of Cancer Patients. Korean J Orient Int Med 23(1):117-122, 2002.
34 Jung, J.H., Seo, J.C., Kwak, M.A., Sohn, K.C. Literature Review on Traditional Chinese Medicine Treatment of Gastric Cancer. Korean J Orient Int Med 35(3):332-342,2014.
35 Rockwell, S., Grove, T.A., Liu, Y., Cheng, Y.C., Higgins, S.A., Booth, C.J. Preclinical studies of the Chinese Herbal Medicine formulation PHY906 (KD018) as a potential adjunct to radiation therapy. Int J Radiat Biol 89(1):16-25, 2013.   DOI
36 Lam, W., Jiang, Z., Guan, F., Huang, X., Hu, R., Wang, J., et al. PHY906(KD018), an adjuvant based on a 1800-year-old Chinese medicine, enhanced the anti-tumor activity of Sorafenib by changing the tumor microenvironment. Sci Rep 5: 9384, 2015.   DOI
37 Liu, S.H., Cheng, Y.C. Old formula, new Rx: the journey of PHY906 as cancer adjuvant therapy. J Ethnopharmacol 140(3):614-623, 2012.   DOI
38 Lam, W., Bussom, S., Guan, F., Jiang, Z., Zhang, W., Gullen, E.A., et al. The four-herb Chinese medicine PHY906 reduces chemotherapy-induced gastrointestinal toxicity. Sci Transl Med 2(45):45ra59, 2010.   DOI
39 Nagano, T., Itoh, H., Takeyama, M. Effect of Dai-kenchu-to on levels of 3 brain-gut peptides (motilin, gastrin and somatostatin) in human plasma. Biol Pharm Bull 22(10):1131-1133, 1999.   DOI
40 Shibata, C., Sasaki, I., Naito, H., Ueno, T., Matsuno, S. The herbal medicine Dai-Kenchu-Tou stimulates upper gut motility through cholinergic and 5-hydroxytryptamine 3 receptors in conscious dogs. Surgery 126(5):918-924, 1999.   DOI
41 Kono, T., Shimada, M., Yamamoto, M., Kaneko, A., Oomiya, Y., Kubota, K., et al. Complementary and synergistic therapeutic effects of compounds found in Kampo medicine: analysis of daikenchuto. Front Pharmacol 6: 159, 2015.   DOI
42 Hu, X., Sato, J., Oshida, Y., Xu, M., Bajotto, G., Sato, Y. Effect of Gosha-jinki-gan (Chinese herbal medicine: Niu-Che-Sen-Qi-Wan) on insulin resistance in streptozotocin-induced diabetic rats. Diabetes Res Clin Pract 59(2):103-111, 2003.   DOI
43 Mizuno, K., Kono, T., Suzuki, Y., Miyagi, C., Omiya, Y., Miyano, K., et al. Goshajinkigan, a traditional Japanese medicine, prevents oxaliplatin-induced acute peripheral neuropathy by suppressing functional alteration of TRP channels in rat. J Pharmacol Sci 125(1):91-98, 2014.   DOI