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Inhibition of $A{\beta}42$ Fibrillation and Toxicity with ${\beta}$-Asarone  

Kim, Jia (School of Korean Medicine, Pusan National University)
Lee, Chul Won (School of Korean Medicine, Pusan National University)
Lee, Boo Kyun (School of Korean Medicine, Pusan National University)
Lee, Jang Cheon (School of Korean Medicine, Pusan National University)
An, Won Gun (School of Korean Medicine, Pusan National University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.28, no.3, 2014 , pp. 317-321 More about this Journal
Abstract
Amyloid-${\beta}$ protein ($A{\beta}$) is a pathological component of Alzheimer's disease (AD) by participating in the senile plaque formation in the patient's brain. Although the exact mechanism of $A{\beta}$ toxicity is not fully elucidated, it is considered to be closely related to its fibrillation process. For prevention of AD, recent studies have suggested various small molecules which inhibit $A{\beta}$ fibrillation. In this report, ${\beta}$-asarone found in acorus plant has been investigated as an anti-amyloid molecule. ${\beta}$-Asarone was demonstrated to prevent in vitro fibrillation of $A{\beta}$ by inducing the oligomer formation that obviously decreased cytotoxicity. Therefore, ${\beta}$-asarone could be suggested as an inhibitory agent of $A{\beta}$ fibrillation and toxicity, which would help us not only to understand underlying principle of amyloidogenesis mechanism but also to develop a controlling strategy toward AD.
Keywords
Amyloidogenesis; Amyloid-${\beta}$; Neurodegenerative disorders; Alzheimer's disease; ${\beta}$-Asarone; Acorus gramineus soland;
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