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Effect of Sopung-tang and tDCS on Motor function Recovery and GDNF Expression in Photothrombotic Brain Infarction Induced Rat Model  

Sim, Ki Cheol (Chung-yeon Oriental Medicine hospital)
Kim, Gi Do (Department of Physical Therapy, International University of Korea)
Kim, Kyung Yoon (Department of Physical Therapy, Dongshin University)
Chung, Hun Woo (Department of Oriental Medicine of Dongshin University)
Kim, Gye Yeop (Department of Physical Therapy, Dongshin University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.26, no.6, 2012 , pp. 894-901 More about this Journal
Abstract
The effect of Sopung-tang(SPT) and trans-cranial direct current stimulation(tDCS) was investigated in photothrombotic brain infarction(PTI) rats. Sprague-Dawley 80 rats, were divided into four groups. group I was experiental control group(n=20), group II was PTI induced and oral administration of SPT(n=20), group III was PTI induced and tDCS administration(n=20) and group IV was PTI induced and SPT and tDCS administration for 28 days on stroke rats(n=20). Analysis the neurological function test, 25 point behavior functional score test, and immunohistochemistric finding of GDNF expression, and electron microscopy assessment In motor behavior test, the outcome of group IV was significantly difference than the other group, and In immunohistochemistric finding, group II, III, IV were increase GDNF expression on 28 days, In electron microscopy finding, the all groups were degenerated of cell organelles, and synaptic plasticity were improvement of group II, III, IV(especially group IV) These results suggest that, 28days application of SPT and tDCS was the motor function and histopathologic, micro-morphological improvement of motor function recovery and positive influence on synaptic plasticity.
Keywords
photothrombotic brain infarction; Sopung-tang; tDCS; GDNF;
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1 Watson, B.D., Dietrich, W.D., Busto, R., Wachtel, M.S., Ginsberg, M.D. Induction of reproducible brain infarction by photochemically initiated thrombosis. Ann Neurol. 17: 497-504, 1985.   DOI   ScienceOn
2 김상준. 중풍 백서에서 반복적 경두개 직류 전기 자극에 의한 운동 기능 회복 기전. 서울대학교 대학원 박사학위논문, 2009.
3 Bederson, J.B., Germano, I.M., Guarino, L. Cortical blood flow and cerebral perfusion pressure in a new noncraniotomy model of subarachnoid hemorrhage in the rat. Stroke. 26: 1086-1091, 1995.   DOI   ScienceOn
4 Feldman, Z., Gurevitch, B., Artru, A.A., Oppenheim, A., Shohami, E., Reichenthal, E., Shapira, Y. Effect of magnesium given 1 hour after head trauma on brain edema and neurological outcome. J Neurosurg. 85: 131-137, 1996.   DOI   ScienceOn
5 Paulus, W. Transcranial direct current stimulation (tDCS). Suppl Clin Neurophysiol. 56: 249-254, 2003.
6 Wassermann E.M., Grafman J. Recharging cognition with DC brain polarization. Trends Cogn Sci. 9(11):503-505, 2005.   DOI   ScienceOn
7 Kumiko, T., Atsushi, S., Hideki, H., Takashi, S., Hidenori, S. Overexpression of GDNF in the Uninjured DRG Exerts Analgesic Effects on Neuropathic Pain Following Segmental Spinal Nerve Ligation in Mice. The Journal of Pain. 12(11):1130-1139, 2011.   DOI   ScienceOn
8 Carmichael, S.T. Cellular and molecular mechanisms of neural repair after stroke: making waves. Annals of Neurology. 59(5):735-742, 2006.   DOI   ScienceOn
9 Langhorne, P., Coupar, F., Pollock, A. Motor recovery after stroke: a systematic review. Lancet Neurol. 8: 741-754, 2009.   DOI   ScienceOn
10 Edwards, M.T., Murphy, M.M., Geraghty, J.J., Wulf, J.A., Konzen, J.P. Intra-arterial cerebral thrombolysis for acute ischemic stroke in a community hospital. AJNR Am J Neuroradiol. 20(9):1682-1687, 1999.
11 공정현. 萬病回春. 서울, 행림서원, pp 55-57, 1975.
12 허준. 동의보감. 서울, 동의보감, p 992, 2005.
13 정장균. 疏風湯이 실험동물의 심혈관계에 미치는 영향. 동의병리학회지 10: 317-340, 1995.
14 문영희, 정명현, 주홍규, 임동윤, 유호진. 疏風湯이 흰쥐의 혈압에 미치는 영향. 생약학회지 21(2):173-178, 1990.
15 정장균, 안일회. 疏風湯이 뇌혈전증 초기환자에 미치는 영향. 원광한의학. 5: 181-195, 1995.
16 추민규, 최진봉, 신미숙, 김선종. 疏風湯이 허혈성 뇌손상흰쥐의 인지 및 운동기능 회복에 미치는 영향. 한방재활의학과학회지 18(2):45-60, 2008.
17 권영철, 이경섭. 疏風湯및 加味疏風湯이 고지혈증에 미치는 영향. 경희한의대논문집. 5: 269-279, 1982.
18 Nitsche, M.A., Cohen, L.G., Wassermann, E.M., Priori, A., Lang, N., Antal, A., Paulus, W., Hummel, F., Boggio, P.S., Fregni, F., Pascual-Leone, A. Transcranial direct current stimulation: State of the art 2008. Brain Stimul. 1(3):206-223, 2008.   DOI   ScienceOn
19 Fregni, F., Boggio, P.S., Nitsche, M., Bermpohl, F., Antal, A., Feredoes, E., Marcolin, M.A., Rigonatti, S.P., Silva, M.T., Paulus, W., Pascual-Leone A. Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory. Exp Brain Res. 166(1):23-30, 2005.   DOI   ScienceOn
20 Antal, A., Varga, E.T., Kincses, T.Z., Nitsche, M.A. Paulus, W. Oscillatory brain activity and transcranial direct current stimulation in humans. Neuroreport. 15(8):1307-1310, 2004.   DOI   ScienceOn
21 Ito, M. Mechanisms of motor learning in the cerebellum. Brain Res. 886(1-2):237-245, 2000.   DOI   ScienceOn
22 Hummel, F., Celnik, P., Giraux, P., Floel, A., Wu, W.H., Gerloff, C., Cohen, L.G. Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke. Brain. 128(3):490-499, 2005.   DOI   ScienceOn
23 Beck, K.D., Valverde, J., Alexi, T., Poulsen, K., Moffat B., Vandlen R.A., Rosenthal, A,. Hefti, F. Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature. 373(6512):339-341, 1995.   DOI   ScienceOn
24 Sauer, H., Rosenblad, C., Bjorklund, A. Glial cell line-derived neurotrophic factor but not transforming growth factor beta 3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion. Proc Natl Acad Sci USA. 92(19):8935-8939, 1995.   DOI   ScienceOn
25 Sanes, J.N. Neocortical mechanisms in motor learning. Curr Opin Neurobiol. 13(2):225-231, 2003.   DOI   ScienceOn
26 Rema, V., Ebner, F.F. Effect of enriched environment rearing on impairments in cortical excitability and plasticity after prenatal alcohol exposure. J Neurosci. 19(24):10993-11006, 1999.   DOI
27 최서우. 소풍탕이 고지혈증 흰쥐의 뇌경색에 미치는 영향. 경원대학교 대학원 박사학위논문, 2008.
28 Paxinos, G., Watson, C. The rat brain in stereotactic coordinates. 5th ed Sydney Academic press. 9: 203, 2004.
29 전국한의과대학심계내과교실. 심계내과학. 서울, 군자출판사, p 331, 1996.
30 Kim, M.S., Shin, Y.I., Kim, H.I., Moon, S.K., Lee, S., Moon, B.S., Lee, M.C. Relevance of behavioral test in the photothrombotic stroke rat model. J of Korean Acad of Rehab Med. 30(2):135-141, 2006.
31 Fisher, M. The ischemic penumbra: identification, evolution and treatment concept. Cerebrovasc Dis. 17(1):1-6, 2004.   DOI   ScienceOn
32 Sigler, A., Goroshkov, A., Murphy, T.H. Hardware and methodology for targeting single brain arterioles for photothrombotic stroke on an upright microscope. Journal Neuroscience Methods. 170(1):35-44, 2008.   DOI   ScienceOn
33 Yuh, W.T.C., Ueda, T., White, M., Schuster, M.E., Taoka, T. The need for objective assessment of the new imaging techniques and understanding the expanding roles of stroke imaging. AJNR. 20: 1779-1784, 1999.