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Effects of Root of Liriope Spicata on LPS-induced Lung Injury  

Lee, Eung-Seok (Division of Respiratory System, Department of Internal Medicine, Daejeon University)
Yang, Soo-Young (Division of Respiratory System, Department of Internal Medicine, Daejeon University)
Kim, Min-Hee (Department of Neurophysiology, College of Oriental Medicine, Daejeon University)
NamGung, Uk (Department of Neurophysiology, College of Oriental Medicine, Daejeon University)
Park, Yang-Chun (Division of Respiratory System, Department of Internal Medicine, Daejeon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.25, no.4, 2011 , pp. 641-649 More about this Journal
Abstract
This study was purposed to evaluate the effects of root of Liriope spicata (RLS) on LPS-induced COPD (chronic obstructive pulmonary disease) model. The extract of RLS was treated to A549 cells and LPS-induced COPD mice model. Then, various parameters such as cell-based cyto-protective activity and histopathological finding were analyzed. RLS showed a protective effect on LPS-induced cytotoxicity in A549 cells. This effect was correlated with analysis for caspase 3 levels, protein level of cyclin B1, Cdc2, and phospho-Erk1/2, and gene expression of TNF-${\alpha}$ and IL-$1{\beta}$ in A549 cells. RLS treatment also revealed the protective effect on LPS-induced lung injury in COPD mice model. This effect was evidenced via histopathological finding including immunofluence stains against caspase 3, and protein level of cyclin B1, Cdc2, and Erk1/2 in lung tissue. These data suggest that RLS has a pharmaceutical properties on lung injury. This study would provide an scientific evidence for the efficacy of RLS for clinical application to patients with COPD.
Keywords
root of Liriope spicata; chronic obstructive pulmonary disease; emphysema; A549 cell;
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