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Caesalpinia sappan L. Induces G2/M Phase Cell Cycle Arrest in Human Lymphoma U937 Cells  

Jeon, Byung-Jae (Department of Pathology, College of Oriental Medicine, Wonkwang Unviersity)
Ju, Sung-Min (Department of Pathology, College of Oriental Medicine, Wonkwang Unviersity)
Yang, Hyun-Mo (Department of Pathology, College of Oriental Medicine, Wonkwang Unviersity)
Kim, Bo-Hyun (Division of Natural Science, College of Natural Sciences, Wonkwang Unviersity)
Kim, Won-Sin (Division of Natural Science, College of Natural Sciences, Wonkwang Unviersity)
Jeon, Byung-Hun (Department of Pathology, College of Oriental Medicine, Wonkwang Unviersity)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.24, no.1, 2010 , pp. 55-60 More about this Journal
Abstract
Caesalpinia sappan L. (C. sappan) has long been used in traditional medicine as an emmenagogue, hemostatic and anti-inflammatory agent. The present study investigated the effects of water extract of C. sappan in human lymphoma U937 cells. The proliferation of U937 cells was decreased by C. sappan in a dose-dependently manner. Anti-proliferative effect of C. sappan on U937 cells was associated with G2/M phase arrest, which was mediated by regulating the expression of p21 protein. Moreover, phosphorylation of JNK and p38 was increased by C. sappan. Blockade of JNK and p38 was significantly inhibited C. sappan-induced G2/M phase arrest. Taken together, these results suggest that Anti-proliferative effect of C. sappan on U937 is assocated with G2/M phase cell cycle arrest by expression of p21 protein and, JNK and p38 activation.
Keywords
Caesalpinia sappan L.; U937 cells; Cell cycle arrest; G2/M phase; p21; JNK; p38;
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