Browse > Article

Anti-inflammatory Effect of Potentillae Chinensis Herba Water Extract on the Proteinase-activated Receptor2-mediated Paw Edema  

Lim, Jong-Pil (College of Pharmacy, Woosuk University)
Lee, Hong-Kyu (College of Pharmacy, Woosuk University)
Jeon, Hoon (College of Pharmacy, Woosuk University)
Lim, Bo-Ra (Department of Experimental Therapeutics, School of Medicine, University of Pennsylvania)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.23, no.6, 2009 , pp. 1444-1448 More about this Journal
Abstract
Potentilla chinensis Ser. (Rosaceae) has long been used for a remedy of diarrhea and inflammation in Korea. In this study, the anti-inflammatory effects of the Potentillae chinensis Herba water extract (PCX) was investigated in proteinase-activated receptor-2 (PAR2)-mediated rat paw edema. Paw edema was induced by injection of trypsin or trans-cinnamoyl-LIGRLO-$NH_2$ (tc-$NH_2$) into the hind paw of rats. PCX (10, 50, 100 and 200 mg/kg) was orally administered 1 h before the induction of inflammation. At doses of 50, 100 and 200 mg/kg, PCX showed significant inhibition on both change in paw volume and vascular permeability. PCX (100 mg/kg) significantly inhibited PAR2 agonists-induced myeloperoxidase (MPO) activity in paw tissue. These results indicate that PCX has an anti-inflammatory action in PAR2-mediated paw edema.
Keywords
potentilla chinensis; anti-inflammatory; trypsin; tc-$NH_2$; paw edema;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Coughlin, S.R. How the protease thromgin talks to cells. Proc Natl Acad Sci USA 96(20):11023-11027, 1999   DOI   ScienceOn
2 Molino, M., Barnathan, E.S., Numerof, R., Clark, J., Dreyer, M., Cumashi, A,, Hoxie, J.A., Schechter, N., Woolkalis, M., Brass, L.F. Interactions of mast cell tryptase with thrombin receptors and PAR-2. J Biol Chem 272: 4043-4039, 1997   DOI   ScienceOn
3 Steinhoff, M., Vergnolle, N., Toung, S.H., Tognetto, M., Amadesi, S., Ennes, H.S., Trevisani M., Hollenberg, M.D., Wallace, J.L., Caughey, G.H., Mitchell, S.E., Williams, L.M., Geppetti, P., Mayer, E.A., Bunnett, N.W. Agonists of protease-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat Med 6: 151-158, 2000   DOI   ScienceOn
4 Wang, Q.H., Li, Z.Y., Shen, Y., Lin, H.W., Shu, W.Z. Studies on triterpenoids from Potentilla chinensis, J B Zhongguo Zhong Yao Za Zhi 31(17):1434-1436, 2006
5 Vergnolle, N., Hollenberg, M.D., Sharkey, K.A., Wallace, J.L. Characterization of the inflammatory response to proteinase-activated receptor-2 (PAR-2) -activating peptides in the rat paw. Br J Pharmacol 127: 1083-1090, 1999   DOI   ScienceOn
6 Armstrong, N.C., Ernst, E. The treatment of eczema with Chinese herbs: a systematic review of randomized clinical trials. Br J Clin Pharmacol 48(2):262-264, 1999   DOI   ScienceOn
7 Ishihara, H., Connolly, A.J., Zeng, D., Kahn, M.L., Zheng, Y.W., Timmons, C., Tram, T., Coughlin, S.R. Protease-activated receptor-3 is a second thrombin receptor in humans. Nature 386: 502-506, 1997   DOI   ScienceOn
8 Lohman, R.J., Jones, N.C., O'Brien, T.J., Cocks, T.M. A regulatory role for protease-activated receptor-2 in motivational learning in rats. Neurobiol Learn Mem 92(3):301-309, 2009   DOI   ScienceOn
9 Macfarlane, S.R., Seatter, M.J., Kanke, T., Hunter, G.D., Plevin, R. Preteinase-activated receptors. Pharmacol Rev 53: 245-249, 2001   PUBMED
10 Howells, G.L., Macey, M., Chinni, C., Hou, L., Fox, M.T., Harriott, P., Stone, S. Proteinase-activated redeptor-2: expression by human neutrophils. J. Cell Sci 110: 881-887, 1997   PUBMED   ScienceOn
11 Bohn, S.K., Kong, W., Bromme, D., Smeekens, S.P., Anderson, D.C., Connolly, A., Kahn, M., Nelken, N.A., Coughlin, S.R., Payan, D.G., Bunnett, N.W. Molecular cloning expression and potential functions of the human proteinase-activated receptor-2. Biochem J 314: 1009-1013, 1996   DOI   PUBMED
12 Hollenberg, M.D., Saifeddine, M., Al-Ani, B. Proteinase-activated receptor-activating peptides. Mol Pharmcol 49: 229-232, 1996
13 Corvera, C.U., Dery, O., McConalogue, K., Bohm, S.K., Khitin, L.M., Caughey, G.H., Payan, D.G., Bunnett, N.W. Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2. J Clin Invest 100(6):1383-1393, 1997   DOI   ScienceOn
14 Bradley, P.P., Priebat, D.A., Christensen, R.D., Rothstein, G. Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker. J Invest Dermatol 78(3):206-209, 1982   DOI   ScienceOn
15 Kawabata, A., Kureda, R., Imnami, T., Kataka, K., Taneda, M. Increased vascular permeability by a specific agonist of protease-activated receptor-2 in rat hidpaw. Br J Pharmacol 125: 419-422, 1998   DOI   ScienceOn
16 Miike, S., McWiliam, A.S., Kita, H. Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2. J Immunol 167(11):6615-6622, 2001   DOI   PUBMED
17 Kong, W., Mcconalogue, K., Khitin, L.M., Hollenberg, M.D., Payan, D.G., Bohm, S.K., Bunnett, N.W. Luminal trypsin may regulate enterocytes through proteinase-activated receptor-2. Proc. Natl Acad Sci USA 94: 8884-8889, 1997   DOI   ScienceOn
18 Kim, C.M., Shin, M.K., Ahn, D.K., Lee, K.S. Great Chinese Medicine Dictionary, Jungdam Co. p 4294, 1998
19 Katayama, S., Shionoya, H., Ohtake, S. A new method for extraction of extravasated dye in the skin and the influence of fasting stress on passif cutaneous anaphylaxis in guinea pigs and rats. Microbiol Immunol 22(2):89-101, 1978   DOI   PUBMED
20 Nystedt, S., Emilsson, K., Wahlestedt, C., Sundelin, J. Molecular cloning of a potential proteinase activated receptor. Proc Natl Acad Sci USA 91: 9208-9213, 1994   DOI   ScienceOn
21 Kahn, M.L., Zheng, Y.W., Huang, W., Bigornia, V., Zeng, D., Moff, S., Farese, R.V.Jr., Tam, C., Coughlin, S.R. A dual thromgin receptor system for platelet activation. Nature 394(6694):690-694, 1998   DOI   PUBMED   ScienceOn
22 Morla, L., Crambert, G., Mordasini, D., Favre, G., Doucet, A., Imbert-Teboul, M. Proteinase-activated receptor 2 stimulates Na,K-ATPase and sodium reabsorption in native kidney epithelium. J Biol Chem 283(42):28020-28024, 2008   DOI   ScienceOn
23 Nystedt, S., Ramakrishnan, B., Sundelin, J. The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. J Bil Chem 271:14910-14915, 1996   DOI   ScienceOn
24 Vergnolle, N., Macnaughton, W.K., Al-Ani, B., Saifeddine, M., Wallace, J.L., Hollenberg, M.D. Proteinase-activated receptor-2-activating peptides: identification of a receptor that regulates intestinal transport. Proc Natl Acad Sci USA 95: 7766-7771, 1998   DOI   ScienceOn
25 Vu, T.K., Hung, D.T., Wheaton, V.I., Coughlin, S.R. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64: 1057-1062, 1991   DOI   ScienceOn