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Study on Anti-obesity Effect of Chegameuiin-tang  

Park, Tae-Yong (Department of Oriental Rehabilitation, College of Oriental Medicine, Wonkwang University)
Shin, Byung-Cheul (Department of Oriental Rehabilitation, College of Oriental Medicine, Wonkwang University)
Kong, Jae-Cheol (Department of Oriental Rehabilitation, College of Oriental Medicine, Wonkwang University)
Song, Mi-Young (Department of Biochemistry, Medical School and Institute for Medical Sciences, Chonbuk National University)
Kim, Eun-Kyung (Department of Biochemistry, Medical School and Institute for Medical Sciences, Chonbuk National University)
Seo, Eun-A (Department of Food and Nutrition, School of Human Envioronmental Science, Wonkwang University)
Ryu, Do-Gon (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kwon, Kang-Beom (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.22, no.3, 2008 , pp. 642-648 More about this Journal
Abstract
The aim of this study is to investigate Chegameuiin-tang water extracts (CETE) have potent anti-obesity activities in a high fat diet-induced obesity mouse model. In this study, we designed three group (normal diet group, high fat diet group, high fat diet plus CETE group for 13-week oral administration). Increases in body weight and fat storage were inhibited by 13-week oral administration of CETE at a 500 mg/kg concentration in this animal model, while the amount of food intake was not affected. Results from blood lipid analysis showed that the levels of triglyceride, total cholesterol and LDL-cholesterol were significantly lowered by CETE administration, also HDL-cholesterol was increased more than high fat diet-induced obese mouse. To understand the underlying mechanism at the molecular level, the effects of CETE were examined on the expression of the genes involved in lipogenesis and lipolysis by real-time PCR. In epididymal fat of CETE-treated mice, the mRNA level of lipogenic genes such as sterol regulatory element binding protein 1 and fatty acid synthase were decreased, which was well correlated with the reduction of the epididymal fat weight. Also, CETE administration inhibited decreases of the hormone-sensitve lipase and lipoprotein lipase mRNA expressions, which are genes related with lipolysis. These results suggest that Chegameuiin-tang may have great potential as a novel anti-obesity agent.
Keywords
Chegameuiin-tang(體減薏苡仁湯); obesity; high fat diet; sterol regulatory element binding protein 1; fatty acid synthase; hormone sensitive lipase; lipoprotein lipase;
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