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Neuroprotective Efects of Gagam-ChongMeong-Tang on Cognitive Function after Ischemic Brain Injury in Rats  

Kim, Kyung-Yoon (College of Health and Welfare, Dongshin University)
Kim, Hyung-Woo (College of Oriental Medicine)
Lee, Sang-Yeong (College of Oriental Medicine)
Cha, Dae-Yeon (College of Oriental Medicine)
Lee, Seok-Jin (College of Oriental Medicine)
Kim, Gye-Yep (College of Health and Welfare, Dongshin University)
Kim, Hang-Jung (Jeonnam Herbal Medicine Farmer's Cooperrative)
Jeong, Hyun-Woo (College of Oriental Medicine)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.22, no.3, 2008 , pp. 556-561 More about this Journal
Abstract
ChongMyeong-Tang (CMT) have been used clinically to treat patient with amnesia and dementia. In addition, CMT have been also used for examinee to improve learning ability in Korea. This study was designed to investigate the effects of Gagam-ChongMeong-Tang (GCMT) on cognitive dysfunction recovery after ischemic brain injury in rats. Rats were divided into three groups; (1) normal, (2) commercial diet after ischemic brain injury (control), (3) CMT diet after ischemic brain injury (experiment). In our study, we carried out Morris water maze test for cognitive motor behavior test and immunohistochemistry study through the change BDNF in the hippocampus($7^{th},\;14^{th}\;day$). In Morris water maze test, cognitive motor function recovery was significantly increased in the experiment group as compared with control group on $7^{th}\;and\;14^{th}\;day$ day (p<0.01). In immunohistochemistric response of BDNF in the hippocampus, more immune reaction was investigated in the experiment group as compared with control group on $7^{th}\;and\;14^{th}\;day$. Especially more immune reaction was experimented $14^{th}$ day. These results imply that GCMT can play a role in facilitating recovery of cognitive function after ischemic brain injury in rats.
Keywords
Gagam-ChongMyeong-Tang(GCMT); Cognitive Function; Morris water maze; Brain-derived Neurotrophic Factor (BDNF);
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1 Najeson, T., Rahmani, L., Elazar, B., Averbuch, S. An elementary cognitive assessment and treatment of the craniocerebrally injured patient In Edelstein B.A. & Couture E.T. (Eds). Behavioral assessment and rehabilitation of the traumatically brain damaged. New York, Plenum Press p 131, 1984
2 민성길. 최신정신의학. 서울, 일조각, pp 29-30, 101-102, 1991
3 Vaynman, S., Ying, Z., Gomez-Pinilla, F. Hippocalpal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition, Eur J. Neurosci 20(10):2580-2590, 2004   DOI   ScienceOn
4 Karege, F., Bondilfi, G., Gervasoni, N., Schwald, M., Aubry, J.M. Bertschy, G. Low brain-derived neurotrophic factor(BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet activity. Biol Psychiatry 57: 1068-1072, 2005   DOI   ScienceOn
5 Longa, E.Z., Weinstein, P.R., Carison, S., Cummins, R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20(1):84-91, 1989   DOI   ScienceOn
6 Garcia, J.H., Wagner, S., Liu, K.F., Hu, X.J. Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats; Statistical validation. Stroke 26: 627-634, 1995   DOI   ScienceOn
7 Vernadakis, A. Glia-neuron intercommunications and synaptic plasticity. Prog Neurobiol 49(3):185-214, 1996   DOI   ScienceOn
8 黃度淵. 證脈方藥合編. 서울, 남산당, p 197, 1994
9 Sutherland, R.J., Rodriguez, A.J. The role of the fomix/ fimbria and some related subcortical structures in place learning and memory. Behavioral Brain Research 32: 265-277, 1989   DOI   ScienceOn
10 彭怀仁. 中華名醫方劑大全. 북경, 금순출판사, p 748, 1990
11 Fordyce, D.E., Wehner, J.M. Physical activity enhances spatial learning performance with an associated alteration in hippocampal protein hinase C activity in C57BL/6 and DBA/2 mice. Brain Res. 619(1-2):111-119, 1993   DOI
12 강형원, 류영수, 이종길. 뇌신경교 성상세포로부터 종양괴사인자 알파의 생성에 있어서 총명탕의 효과. 동의신경정신과학회지 10(1):109-119, 1999
13 Johansson, B.B. Brain plasticity and stroke rehabilitation; The Willis Lecture. Stroke 31(1):223-230, 2000   DOI   ScienceOn
14 허 준. 東醫寶鑑. 서울, 남산당, pp 98-99, 1987
15 Clark, A.S,. Mitre, M.C., Brinck-Johnsen, T. Anabolic androgenic steroid and adrenal steroid effects on hippocampal plasticity. Brain Res. 679(1):64-71, 1995   DOI   ScienceOn
16 陳羅雷. 古今圖書集成醫部全錄(제7권). 북경, 인민위생출판사, p 2150, 1983
17 Lezak, M.D. Neuropsychological Assessment(4rd Ed.). New York, Oxford University Press pp 22-23, 1995
18 Yamazaki, M., Matsuoka, N., Kuratani, K., Ohkubo, Y., Yamaguchi, I. FR121196, a potential antidementia drug, ameliorates the impaired memory of rat in the Morris water maze. J. Pharmacol Exp Ther. 272(1):256-263, 1995
19 Gomez-Pinilla, F., Vaynman, S. A "deficient environment" in prenatal life may compromise systems important for cognitife function by affecting BDNF in the hippocampus. Exp Neurol. 192: 235-243, 2005   DOI   ScienceOn
20 Buchan, A.M., Pulsineli, W.A. Hypothermia but not the N-methyl-D-aspartate receptor antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia. J. Neurosci. 11: 1049-1050, 1990
21 김인재, 이상룡. 加味歸脾聰明湯이 노화 백서의 혈액변화 및혈청과 뇌조직의 항산화물 활성에 미치는 영향. 동의신경정신과학회지 9(2):53-69, 1998
22 Gill, R., Foster, A., Woodruff, G. MK-801 is neuroprotective in gerbils when administered during the post-ischemic period. Neuroscience 25: 847-855, 1988   DOI   ScienceOn
23 Kupgemann, I.L. Priciples of neural science(2nd ed.). New York, Elsvier pp 806-815, 1986