Browse > Article

Effects of Amomum villosum(AMV) Extract on the Alzheimer's Disease Model  

Choi Bo-Yun (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Daejeon University)
Jung In-Chul (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Daejeon University)
Lee Sang-Ryong (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Daejeon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.1, 2006 , pp. 43-51 More about this Journal
Abstract
This experiment was designed to investigate the effect of Amomum villosum(AMV) on the Alzheimer's disease. The effects of AMV extract on amyloid precursor proteins(APP), acetylcholinesterase(AChE), glial fibrillary acidic protein(GFAP) mRNA of PC-12 cell line treated by amyloid $\beta$ protein($A{\beta}$) : IL-$1{\beta}$, IL-6, TNF-$\alpha$ mRNA of THP-1 cell line treated by lipopolysaccharide(LPS) : AChE activity of PC-12 cell lysate treated by $A{\beta}$ : serum glucose, uric acid, AChE activity of memory deficit rats induced by scopolamine : behavior of memory deficit mice induced by scopolamine were investigated, respectively. AMV extract suppressed APP, AChE, GFAP mRNA in PC-12 cell treated by $A{\beta}$ : IL-$1{\beta}$, IL-6, TNF-$\alpha$ mRNA in THP-1 cell treated by LPS , AChE activity in cell lysate of PC-12 cell treated by $A{\beta}$. AMV extract increased glucose, decreased uric acid and AChE significantly in the serum of the memory deficit rats induced by scopolamine. AMV extract group showed significantly inhibitory effect on the memory deficit of mice induced by scopolamine in the experiment of Morris water maze. According to the above results, it is suggested that AMV extract might be usefully applied for prevention and treatment of Alzheimer's disease.
Keywords
Amomum villosum(AMV); Dementia; Alzheimer's disease; ${\beta}A$; cytokine;
Citations & Related Records
연도 인용수 순위
  • Reference
1 黃宮繡 : 本草求眞, 서울, 一中社, pp 109-110, 1992
2 鄭仁哲, 李相龍 : 溫膽湯이 腦組織이 酸化作用에 미치는 影響, 동의신경정신과학회지, 8(2):51-62, 1997
3 朴鍾雲, 李基商, 文炳淳 : 四物湯이 老化白鼠 腦組織의 生化學的 變化에 미치는 影響, 大韓韓方內科學會誌, 19(1):185-201, 1998
4 Skehan, P., Storeng, R., Scudiero, D., Monk, A., McMahon, J., Visca, D., Warren, J.T., Kennedy, S., Boyd, M.R. New colorimetric cytotoxicity assay for anticancer drug screening. J Natl Cancer Inst, 82(13):1107-1112, 1990   DOI
5 Skehan, P., Storeng, R., Scudiero, D., Monk, A., McMahon, J., Visca, D., Warren, J.T., Kennedy, S., Boyd, M.R. New colorimetric cytotoxicity assay for anticancer drug screening. J Natl Cancer Inst, 82(13):1107-1112, 1990   DOI
6 Zor, T., Selinger, Z. Linearization of the Bradford protein assay increases its sensitivity ; theoretical and experimental studies. Anal Biochem, 236(2):302-308, 1996   DOI   ScienceOn
7 대한동의생리학회편 : 동의생리학, 서울, 경희대학교 출판국, pp 293-294, 1993
8 黃大東 외 : 實用中醫內科學, 上海, 上海科學技術出版社, pp 378-381, 1989
9 의학교육연수원 : 의학연수교육총서 제6집 노인의학, 서울, 서울대학교출판부, pp 4-5, 1999
10 Hu, J., Akama, K.T., Krafft, G.A., Chromy, B.A., Van Eldik, L.J. : Amyloid-beta peptide activates cultured astrocytes ; morphological alterations, cytokine induction and nitric oxide release. Brain Res, 785(2):195-206, 1998   DOI   ScienceOn
11 Kuhl, D.E., Koeppe, R.A., Minoshima, S., Snyder, S.E., Ficaro, E.P., Foster, N.L., Frey, K.A., Kilbourn, M.R. : In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer's disease. Neurology, 52(4):691-699, 1999   DOI   ScienceOn
12 Yan, S.D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., Migheli, A., Naworth, P., Stern, D., Schmidt, A.M. RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease. Nature, 382(6593):685-691, 1996   DOI   ScienceOn
13 洪元植 : 精校黃帝內經素問, 서울, 東洋醫學硏究院, pp 37, 124, 196, 229, 217-218, 229, 1985
14 Degrell, I., Niklasson, F. Purine metabolites in the CSF in presenile and senile dementia of Alzheimer type, and in multi infarct dementia. Arch Gerontol Geriatr, 7(2):173-178, 1998   DOI   ScienceOn
15 申佶求 : 申氏本草學, 서울, 壽文社, pp 582-584, 1988
16 金宇哲 외 : 統計學槪論, 서울, 英志文化社, pp 177-179, 1990
17 許 浚 : 東醫寶鑑, 서울, 법인문화사, p 1947, 1999
18 이광우 편저. 임상신경학, 서울, 범문사, pp 203-215, 2003
19 張介賓 : 張氏景岳全書, 서울, 翰成社, pp 610-611, 1978
20 Kuhl, D.E., Koeppe, R.A., Minoshima, S., Snyder, S.E., Ficaro, E.P., Foster, N.L., Frey, K.A. , Kilbourn, M.R. In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer's disease. Neurology, 52(4):691-699, 1999   DOI   ScienceOn
21 楊思澎 외 : 中醫臨床大全, 北京, 北京科學技術出版社, pp 224-230, 1991
22 陳 輝 외 : 實用中醫腦病學, 北京, 學苑出版社, pp 242-251, 784-791, 1993
23 정인철, 이상룡 : 導痰益氣活血湯이 알츠하이머 질환 병태 모델의 생화학적 변화 및 행동에 미치는 영향, 東醫生理病理學會誌, 15(2):260-276, 2001
24 Multhaup, G., Schlicksupp, A., Hesse, L., et al : The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I). Science, 271(1):1406-1409, 1996   DOI   ScienceOn
25 De Vente, J., Markerink-van, Ittersum, M., Van Abeelen, J., Emson, P.C., Axer, H., Steinbusch, H.W. : NO-mediated cGMP synthesis in cholinergic neurons in the rat forebrain ; effects of lesioning dopaminergic or serotonergic pathways on nNOS and cGMP synthesis. Eur J Neurosci, 12(2):507-519, 2000   DOI   ScienceOn
26 Raskind, M.A., Sadowsky, C.H., Sigmund, W.R., Beitler, P.J., Auster, S.B. : Effect of tacrine on language, praxis, and noncognitive behavioral problems in Alzheimer disease. Arch Neurol, 54(7):836-840, 1997   DOI   ScienceOn
27 이근후. 최신임상정신의학, 서울, 하나의학사, pp 138, 216-228, 1986
28 Downen, M., Amaral, T.D., Hua, L.L., Zhao, M.L., Lee, S.C. Neuronal death in cytokine-activated primary human brain cell culture ; role of tumor necrosis factor-alpha. Glia, 28(2):114-127, 1999   DOI   ScienceOn
29 Fukuyama, R., Izumoto, T., Fushiki, S. : The cerebrospinal fluid level of glial fibrillary acidic protein is increased in cerebrospinal fluid from Alzheimer's disease patients and correlates with severity of dementia. Eur Neurol, 46(1):35-38, 2001   DOI   ScienceOn
30 Selkoe, D.J. The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease. Trends Cell Biol, 8(11):447-453, 1998   DOI   ScienceOn
31 Stephen, L.Y., Loyd, H.B., June, K.A., Joyce, M.A., Michael, D.D., Paula, B.E., Anthony, M.P., Piorkowski, Kurt, R.B. Amyloid $\beta$ and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia. J Neurochem, 74(3):1017-1025, 2000   DOI   ScienceOn
32 Fontana, A., Kristensen, F., Dubs, R., Gemsa, D., Weber, E. : Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells. J Immunol, 129(6):2413-2419, 1983
33 Park, C.H., Kim, S.H., Choi, W., Lee, Y.J., Kim, J.S., Kang, S.S., Suh, Y.H. : Novel anticholinesterase and antiamnesic activities of dehydroevodiamine, a constituent of Evodia rutaecarpa. Planta Med, 62(5):405-409, 1996   DOI   ScienceOn
34 康秉秀 외 : 本草學, 서울, 永林社, pp 294-296, 1992
35 김영숙 : 치매에 대한 통합적 접근법, 서울, 교육과학사, p 3, 2002
36 Li, W.Y., Butler, J.P., Hale, J.E., McClure, D.B., Little, S.P., Czilli, D.L., Simmons, L.K. Suppression of an amyloid beta peptide-mediated calcium channel response by a secreted beta-amyloid precursor protein. Neuroscience, 95(1):1-4, 2000   DOI   ScienceOn
37 孫思邈 : 備急千金要方, 서울, 杏林出版社, pp 129-135, 534, 545, 550, 1982
38 Reznik-Wolf, H., Machado, J., Haroutunian, V., DeMarco, L., Walter, G.F., Goldman, B., Davidson, M., Johnston, J.A., Lannfelt, L., Dani, S.U., Friedman, E. Somatic mutation analysis of the APP and Presenilin 1 and 2 genes in Alzheimer's disease brains. J Neurogenet, 12(1):55-65, 1998   DOI   ScienceOn
39 Cheng, D.H., Tang, X.C. Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities. Pharmacol Biochem Behav, 60(2):377-386, 1998   DOI   ScienceOn
40 손윤경 : Alzheimer병의 신경병리학적 소견과 분자생물학적 연구동향, 계명의대논문집, 16(3):323-338, 1997
41 Messier, C. The absence of effect of glucose on memory is associated with low susceptibility to the amnestic effects of scopolamine in a strain of mice. Behav Brain Res, 96(1-2):47-57, 1998   DOI
42 보건복지부 : 보건사회통계연보, 서울, 보건복지부, pp 236-239, 302-309, 1991