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Th1 and Th2 cytokine Modulation by Baicalin, Baicalein and Wogonin from Scutellaria Radex on the $CD4^+$ Jurkat T Cells  

Kim Young Jun (Department of Skin & Beauty, Seojeong College)
Lee Jeong Chi (Department of Skin & Beauty, Seojeong College)
Kim Hong Yong (Department of Skin & Beauty, Seojeong College)
Xie Guanghua (Department of General Surgery, Affiliated Hospital of Yanbian University College of Medicine)
Yun Yong Gab (Department of Oriental medical prescription, Wonkwang University)
Jang Seon Il (Department of Skin & Beauty, Seojeong College)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.19, no.4, 2005 , pp. 922-927 More about this Journal
Abstract
In the present study, baicalin, baicalein, and wogonin, a major flavone isolated from Scutellaria Radix were examined for their effects on PMA-induced Interlukin-6 (IL-6), $interferon-\gamma(IFN-\gamma)$, tumor necrosis factor $(TNF)-\alpha$, IL-4, IL-10, and IL-13 productions in the PMA-stimulated $CD4^+$ Jurkat T cells. These three compounds inhibited PMA-induced Th1 cytokine $(IL-6,\;IFN-\gamma,\;TNF-\alpha)$ and Th2 cytokine (IL-4 and IL-13) productions in a concentration-dependent manner. But wogonin, but not baicalin baicalein, increased PMA-induced IL-10 production. These results suggest that baicalin, baicalein, and wogonin, a major flavone modulate Th1 and Th2 cytokine productions in $CD4^+$ Jurkat T cells and these properties may contribute to the anti-atopic dermatitis activity of Scutellaria Radix.
Keywords
Scutellaria Radix; baicalin; baicalein; wogonin; Thl; Th2; Jurkat T cells;
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