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Immunosuppressive Activity of Wogonin from Scutellaria Radix on DNFB-induced Delayed Type Hypersensitivity in Mice  

Kim Young Jun (Department of Skin & Beauty, Seojeong College)
Lee Jeong Chi (Department of Skin & Beauty, Seojeong College)
Kim Hong Yong (Department of Skin & Beauty, Seojeong College)
Xie Guanghua (Department of General Surgery, Affiliated Hospital of Yanbian University College of Medicine)
Yun Yong Gab (Department of Oriental medical prescription, Wonkwang University)
Jang Seon Il (Department of Skin & Beauty, Seojeong College)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.19, no.4, 2005 , pp. 1027-1031 More about this Journal
Abstract
In the present study, wogonin, a major flavone isolated from Scutellaria Radix were examined for its imunosuppressive activity on the 2,4-dinitro-fluorobenzene (DNFB)-induced delayed type hypersensitivity (DTH) in C3H/HeN mice. This compound inhibited selectively $TNF-\alpha$ and IL-4, but not IL-6, IL-10 and $IFN-\gamma$ on DNFB-induced Th1 and Th2 cytokines in a concentration-dependent manner. Interestingly, this compound increased the expression of heme oxygenase-1 (HO-1) in a concentration-dependent manner The above results reveal that wogonin possesses anti-inflammatory, humoral and cellular immunomodulatory, and stress reducing activities on the DNFB-induced DTH in mice and these properties may contribute to the anti-atopic dermatitis activity of Scutellaria Radix.
Keywords
Scutellaria Radix; wogonin; DTH; Th1; Th2; HO-1;
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