Browse > Article

Effects of the Ethyl Acetate Soluble Fractions of Sophorae Radix In Langendorff Hearts  

Kwon Kang Beom (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Park Gwan Ha (Department of Marine Biomedical Science, College of Ocean Science of Technology, Kunsan National University)
Kim Woo Kyung (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kim Eun Kyung (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kim Goo Hwan (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Ko Kwang Hak (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Choi Yeon Seong (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Zhang Geun Gook (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Rho Seong Il (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Wonkwang University)
Han Dong Won (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Wonkwang University)
Cha Suk (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University)
Park Dae Young (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University)
Ryu Do Gon (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.5, 2004 , pp. 1309-1316 More about this Journal
Abstract
We previously reported that the ethtyl acetate(EA) soluble fraction of Sophorae Radix(SR) water extract had the preventive effects against cardiovascular anaphylaxis elicited in experimental animals. In this study, we tested the anti-anaphylatic effects of the nine kinds of EA soluble subfractions in animal models such as Langendorff heart and anesthetized rats. These results were obtained as followed ; Among nine kinds of SR EA soluble subfractions, N10-16-2 and N10-16-9 fractions have an effects improving cardiovascular anaphylaxis in guinea pig Langendorff hearts. In passively anesthetized rats, N10-16-2 and N1 0-16-9 fractions of SR EA soluble subfractions have an effects improving cardiovascular anaphylaxis. N10-16-2 and N1 0-16-9 fractions of SR EA soluble subfractions inhibited the decrease of histamine release induced by compound 48180 and A-23187 in rat peritoneal mast cells. These results suggest that N10-16-2 and N10-16-9 fractions of SR EA soluble subfractions involve anti-anaphylactic molecules in cardiovascular system.
Keywords
Sophorae Radix; ethtyl acetate soluble fraction; cardiovascular anaphylaxis; anti-anaphylactic effect; mast cell; Langendorff heart; anesthetized rats;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 /
[ 汪昻 ] / 本草備要解析
2 /
[ 吳普 ] / 神農本草經
3 /
[ 孟憲서 ] / 中成藥分析
4 /
[ 黃官수 ] / 本草求眞
5 /
[ 吳儀洛 ] / 本草從新
6 /
[ 申佶求 ] / 申氏本草學
7 /
[ 李尙仁(外) ] / 漢藥臨床應用
8 /
[ 동의학연구소 ] / 本草學
9 /
[ 鄒澍 ] / 本經疏證
10 急性附子草烏中毒에서 甘豆湯과 苦蔘의 應用 /
[ 李承武(外) ] / 大韓韓醫學會誌
11 /
[ 李廣勛 ] / 中藥藥理毒理與臨床
12 /
[ 董黎明 ] / 實用中醫內科學
13 /
[ 上海中醫學院 ] / 中草藥學
14 苦蔘總鹽抗實驗性心律失常作用的硏究 /
[ 張寶鳳(外) ] / 中藥通報
15 /
[ 王好古 ] / 湯液本草
16 /
[ 唐愼微 ] / 重修政和經史證類備急本草
17 /
[ 李時珍 ] / 本草綱目
18 /
[ 문관심 ] / 약초의 성분과 이용
19 /
[ 陳嘉謨 ] / 本草蒙筌
20 /
[ 辛民敎 ] / 臨床本草學
21 /
[ 中華人民共和國衛生部藥典委員會 ] / 中華人民共和國藥典
22 /
[ 江蘇新醫學院 ] / 新編中藥大辭典
23 /
[ 李淵台 ] / 最新免疫學
24 /
[ 微生物學分科會 ] / 綜合微生物學
25 Alternatives in the diagnosis and treatment of food allergies /
[ King H. C.;W. P., King. ] / Otolaryngol. Clin. North Am.
26 Cost-effective pharmacotherapy for allergic rhinitis /
[ Furguson, B. J. ] / Otolaryngol. Clin. North Am.
27 /
[ 차진헌 ] / 실용동약학
28 Management of immediate allergic reactions /
[ Becker, D. E. ] / Dent. Clin. North Am.
29 Goals of asthma management: a step-care approach /
[ Bone, R. C. ] / Chest
30 Treatment of allergic rhinitis /
[ Suonpaa, J. ] / Ann. Med.   ScienceOn
31 /
[ 康秉秀 ] / 韓方臨床 알레르기
32 苦蔘藥用綜論 /
[ 侯阿兩(外) ] / 中醫藥學報
33 苦蔘在心血管疾病中的應用 /
[ 邱建榮(外) ] / 浙江中醫雜志
34 /
[ 新太陽社 編輯局 百科事典部 ] / 原色最新醫療 大百科事典
35 /
[ 全國韓醫科大學肝系內科學敎授 ] / 肝系內科學
36 苦蔘 전탕액 분획물이 순환기 Anaphylaxis에 미치는 영향 /
[ 권강범;김구환;전영석;조현익;김영석;박관하;백승화;류도곤 ] / 대한한의학회지
37 Prostaglandin, slow-reacting substance and histamine release from anaphylactic guinea-pig hearts and its pharmacological modification /
[ Liebig R.;W. Bernhauer;B. A. Peskar ] / Arch. Pharmacol.   ScienceOn
38 苦蔘 유기용매 분획층이 적출 심장에 미치는 영향 /
[ 김상범;권강범;박준수;박관하;류도곤 ] / 동의생리병리학회지
39 한국산 생약으로부터 항암물질의 개발(제 6부); 금은화·Ethyl Acetate 가용성 분획의 인체 구강유상피암종세포에 미치는 독성작용 /
[ 한두석(외 5인) ] / 한국생약학회지
40 Kinin antagonist does not protect against the hypotensive response to endotoxin, anaphylaxis or acute pancreatitis /
[ Berg T;Schlichting E;Ishida H;Carretero OA. ] / J. Pharmacol. Exp. Ther.
41 Shock organ and shock tissue in various animal species /
[ Melli G.;Folli G.;Mazzei D.;Vitolo E.;Sacchi A. ] / Acta Allergol. (Kbh)
42 Early treatment of atopic child /
[ Warner, J. O. ] / Pediatr. Allergy Immonol.
43 苦蔘鹽類生物鹽的硏究進展及臨床應用 /
[ 李丹(外) ] / 中草藥
44 Cardiac anaphylaxis: Models, mediators, mechanisms, and clinical considerations /
[ Levi R.;Marone(eds.) ] / Humanin flammatory disease, Clinical Immunology
45 순환기 anaphylaxis 저해재 개발에 대한 연구(Ⅱ) /
[ 권강범;이호섭;서은아;김인숙;박관하;류도곤 ] / 대한한국진단학회지
46 Thromboxane and prostacyclin release during immediate hypersensitivity reactions in vitro /
[ Allan G.;R. Levi. ] / J. Pharamcol. Exp. Ther.
47 순환기 anaphylaxis 저해재 개발에 대한 연구(Ⅰ) /
[ 권강범;민영기;조현익;박준배;송봉길;박관하;류도곤 ] / 동의생리학회지
48 수종의 한약재가 순환기 anaphylaxis에 미치는 영향 /
[ 권강범;민영기;조현익;송봉길;김강전;박관하;류도곤 ] / 동의생리학회지
49 Porsius. Characterization and modulation of antigen -induced effects in isolated rat hearts /
[ Vleeming W.;H. H. van Rooij;J. Wemer, A. J. ] / J. Cardiovasc. Pharmacol.   ScienceOn