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Antitumor Effect of the Cotreatment of Paljintanghabhwajeoghwan and $As_2O_3$ in Human Lung Cancer Cell Line H-460  

Song Bong gil (Department of Internal Medicine. College of Oriental Medicine, Wonkwang University)
Won Jin Hee (Department of Internal Medicine. College of Oriental Medicine, Wonkwang University)
Kim Dong Woung (Department of Internal Medicine. College of Oriental Medicine, Wonkwang University)
Lee Jong Duk (Department of Internal Medicine. College of Oriental Medicine, Wonkwang University)
Moon Goo (Department of Internal Medicine. College of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.3, 2004 , pp. 808-818 More about this Journal
Abstract
This study was designed to elucidate the synergistic cytotoxic mechanisms of the cotreatment of Paljintanghabhwajeoghwan (Paljin) and As₂O₃ in human lung cancer cell line, H-460. The combination of Paljin and As₂O₃ synergistically augmented the cytotoxicity of Paljin and As₂O₃ in H-460 cells. The nature of cytotoxicity was revealed as apoptosis which characterized by chromatin condensation and fragmentation in DAPI staining. Mitochodrial membrane potential transition was observed in H-460 cells treated with Paljin and As₂O₃. The apoptotic cytotoxicity of Paljin and As₂O₃ was accompanied by the cleavage of PARP and ICAD. Of note, pro-apoptotic Bak protein was obviously increased. However, the expression of p53 was not affected by the cotreatment of Paljin and As₂O₃. In addition, the expression of DR5 was increased by the cotreatment of Paljin and AS203. This results suggest that the synergistic cytotoxicity of the cotreatment of Paljin and As₂O₃ might be caused by the changes of the expression levels of a lots proteins, such as PARP, ICAD, Bak, DR5, which play pivotal roles in survival or death of cells.
Keywords
Paljintanghabhwajeoghwan(八珍湯合化積丸) As₂O₃ Apoptosis;
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