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Effect of Bambusae Caulis in Liquamen on the Isolated Rat Aorta 중력이 혈관에 미치는 영향

Kim Hyung Chang (Department of Pharmacology, College of Oriental Medicine, Wonkwang University)
Kyung Eun Ho (Department of Pharmacology, College of Oriental Medicine, Wonkwang University)
Na Han Il (Department of Pharmacology, College of Oriental Medicine, Wonkwang University)
Lee Gye Bok (Professional Graduate School of Oriental Medicine, Wonkwang University)
Jeong Mi Ran (Professional Graduate School of Oriental Medicine, Wonkwang University)
Han Jong Hyun (Department of Pharmacology, College of Oriental Medicine, Wonkwang University)

Publication Information

Journal of Physiology & Pathology in Korean Medicine / v.18, no.2, 2004 , pp. 457-462 More about this Journal

Abstract

Bambusae Caulis in Liquamen has been used as a herbal medicine for the treatment of heat, paralysis of the hands or feet, or hemiplegia. In the present study, we investigated the effect of Bambusae Caulis in Liquamen to the phenylephrine (PE) induced contraction of isolated rat aorta Contractile force was measured with force displacement transducer under 1.5 g loading tension. Contractions evoked by PE 0.1 μM were significantly increased by low dosage of Bambusae Caulis in Liquamen, decreased by high dosage of Bambusae Caulis in Liquamen. L-NNA, ODQ and propranolol significantly altered the effect of Bambusae Caulis in Liquamen, but indomethacin did not change the relaxation of Bambusae Caulis in Liquamen. These results suggest that Bambusae Caulis in Liquamen can relax EP induced contraction of isolated rat aorta and that this decreasing contraction related to sympathetics.

Keywords

Bambusae Caulis in Liquamen; contraction; relaxation; aorta; phenylehrine;

Citations & Related Records

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