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Effects of Taekunyukmijiwhang-tang on Blood Pressure and Renal function in NO-dependent Hypertensive Rats  

Sohn Eun Jin (Department of Herbal Resources, Professional Graduate School of Oriental Medicine)
Kang Dae Gill (Department of Herbal Resources, Professional Graduate School of Oriental Medicine)
Noh Suk Yeon (Department of Herbal Resources, Professional Graduate School of Oriental Medicine)
Lee An Sook (Department of Herbal Resources, Professional Graduate School of Oriental Medicine)
Yin Ming Hao (Department of Herbal Resources, Professional Graduate School of Oriental Medicine)
Moon Mi Kyung (Department of Herbal Resources, Professional Graduate School of Oriental Medicine)
Yun Young Gab (College Oriental Medicine University)
Lee Ho Sub (Department of Herbal Resources, Professional Graduate School of Oriental Medicine)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.1, 2004 , pp. 84-92 More about this Journal
Abstract
The present study examined the effects of Taekunyukmijiwhang-tang (TV) on blood pressure and renal function in nitric oxide (NO)-dependent hypertensive rats. A phamacological inhibition of nitric oxide synthase (NOS) for 4-6 weeks produces renal vasoconstriction, renal dysfunction, and progressive severe hypertension. Treatment of rats with NG-Nitro-L-arginie methylester (L-NAME) (100 mg/L, 6 weeks), which is a nonspecific NOS inhibitor, cause a sustained increase in systolic blood pressure (SBP), along with the decrease in expression of ecNOS in the kidney and thoracic aorta. The expression of Na, K-ATPase α1 subunit in the kidney was also reduced in the L-NAME induced hypertensive rats group. The renal functional parameters including urine osmolality (Uosm), creatinine clearance (Ccr), which is an index of glomerular filtration (GFR) were decreased in rat with L-NAME induced hypertension. while solute-free water reabsoption (TcH₂O) was unchanged in all experimental group. However, the group combined treated with TV and L-NAME did not develop hypertension and expression of ecNOS in the aorta was restored. The expression of Na/sup +/, K/sup +/-ATpase α1 subunit in the kidney was markedly restored in L-NAME-induced hypertension rats by administration of TV along with the restoration of urinary volume (UV) and sodium excretion (UNaV), whlie Na/sup +/, K/sup +/-ATPase /β1 subunit was not altered. These results suggest that TV attenuates an increase in SSP in the L-NAME induced hypertension and restores partially renal function, which seems to be caused by up-regulation of expression of Na/sup +/, K/sup +/-ATPase α1 subunit in the kidney and ecNOS in thoracic aorta.
Keywords
Taekunyukmijiwhang-tang(澤君六味地黃湯); NG-Nitro-L-arginie methylester (L-NAME);
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  • Reference
1 ACh dilates pial arterioles in endothelial and neuronal NOS knockout mice by NO-dependent mechanisms /
[ Meng W;Ma J;Ayata C;Hara H;Huang PL;Fishman MC;Moskowitz MA ] / Am J Physiol
2 /
[ 汪인庵 ] / 醫方集解
3 /
[ 허준 ] / 동의보감
4 Herbal phamacology in the people's Republic of China /
[] / Atrip report of the American Herbal phamacology delegation
5 Onthe chinese medicinal plants /
[ Sato J. ] / Japan Society for the promotion of Science
6 /
[ 申佶求 ] / 申氏本草學(總論)
7 /
[ 李商仁 ] / 本草學
8 택사의 Alisol 성분들이 몇가지 Agonist에 대한 적출장관 수축에 미치는 영향 /
[ 윤계숙;정성현;김영숙 ] / 생약학회지
9 /
[ 이경섭 등 ] / 동의심계내과학(上)
10 고혈압에 대한 임상적 고찰 /
[ 김영석 ] / 대한한의학회지
11 /
[ Harrison ] / Harrison's 내과학(II)
12 Role of renal NO production in the regulation of medullary blood flow /
[ Cowley AW Jr;Mori T;Mattson D;Zou AP ] / Am J Physiol   DOI
13 Oral administration of L-arginine decreases blood pressure and increases renal excretion of sodium and water in renovascular hypertensive rats /
[ Gouvea SA;Moyses MR;Bissoli NS;Pires JG;Cabral AM;Abreu GR ] / Braz J Med Biol Res   DOI
14 육미지황탕이 항개량형 마빈신염에 미치는 영향 /
[ 유지윤 ] / 원광대학교 대학원 논문집
15 /
[ 공廷賢 ] / 證補 萬病回春
16 /
[ 李천 ] / 醫學入門
17 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding /
[ Bradford MM ] / Anal Biochem   DOI   ScienceOn
18 /
[ 이근후 ] / 최신임상정신의학
19 치매의 병리 /
[ 지제근 ] / 대한신경과학회지
20 최근 뇌졸중에 대한 역학적 고찰 /
[ 나영설;윤상협;민병일 ] / 경희의학
21 Protective role of endothelial nitric oxide synthase /
[ Albrecht EW;Stegeman CA;Heeringa P;Henning RH;van Goor HJ ] / Pathol
22 Differential expression of iNOS and cNOS mRNA in human vascular smooth muscle cells and endothelial cells under normal and inflammatory conditions /
[ MacNaul KL;Hutchinson NI ] / Biochem Biophys Res Commun   DOI   ScienceOn
23 Involvement of pressure-related mechanism in activation of inducible nitric oxide synthase /
[ Tan DY;Cheng SB;Chen XL;Zhang SM;Yang HZ;Peng X;Tang CS;Zhang C;Meng XZ ] / Sheng Li Xue Bao
24 /
[ 鎭士易 ] / 石室秘錄
25 Nitric oxide activates guanylate cyclase and increases guanosine 3':5'-cyclic monophosphate levels in various tissue preparations /
[ Arnold WP;Mittal CK;Katsuki S;Murad F ] / Proc Natl Acad Sci
26 Effects of NG-nitro-L-arginine methyl ester on renal function and blood pressure /
[ Lahera V;Salom MG;Miranda-Guardiola F;Moncada S;Romero JC ] / Am J Physiol   DOI
27 Direct measurements of endothelium-derived nitric oxide release by stimulation of endothelin receptors in rat kidney and its alteration in salt-induced hypertension /
[ Hirata Y;Hayakawa H;Suzuki E;Kimura K;Kikuchi K;Nagano T;Hirobe M;Omata M ] / Circulation   DOI
28 /
[ 梁頌名 ] / 中藥方濟學
29 /
[ 王錦之 ] / 方劑學
30 /
[ 張恩勤;鄭貴力 ] / 方劑學
31 육미지황탕 전탕액이 가토 혈압 및 백서 간의 TBA에 미치는 영향에 대한 연구 /
[ 김우식;이동희 ] / 경희한의대 논문집
32 육미지황탕이 백서의 혈당량에 미치는 영향 /
[ 허종회;유가원 ] / 경희대 한의대논문집
33 /
[ 方賢 ] / 奇效良方(三冊)
34 /
[ 汪仁庵 ] / 醫方集解
35 Gou-Teng (From Uncaria rhynchophylla Miquel)-induced endothelium-dependent and independent relaxations in the isolated rat aorta /
[ Kuramochi T;Chu J;Suga T ] / Life Sci   DOI   ScienceOn
36 Effect of Uncariae ramulus et Uncus on endothelium in spontaneously hypertensive rats /
[ Goto H;Shimada Y;Tanigawa K;Sekiya N;Shintani T;Terasawa K ] / Am J Chin Med   DOI
37 Vasodilator effect of extract prepared from Uncariae ramulus on isolated rat aorta /
[ Goto H;Sakakibara I;Shimada Y;Kasahara Y;Terasawa K ] / Am J Chin Med   DOI   ScienceOn
38 The direct release of nitric oxide by gypenosides derived from the herb Gynostemma pentaphyllum /
[ Tanner MA;Bu X;Steimle JA;Myers PR ] / Nitric Oxide   DOI   ScienceOn
39 고혈압에서 혈관 산화질소 합성 동위효소 발현변화 /
[ 김인광;강대길;이종은;오봉석 ] / 대한흉부외과학회지
40 Galic prevents hypertension induced by chronic inhibition of nitric oxide synthesis /
[ Pedraza-Chaverri J;Tapia E;Medina-Campos ON;de los Angeles Granados M;Franco M ] / Life Sci
41 Altered renal nitric oxide system in experimental hypertensive rats /
[ Yang ES;Lee JU;Kang DG ] / Kor J Physiol Pharmacol
42 The direct release of nitric oxide by gypenosides derived from the herb Gynostemma pentaphyllum /
[ Lahera V;Salom MG;Steimle JA;Myers PR ] / Biol Chem
43 Relation between pressure natriuresis and urinary excretion of nitrate/ nitrite in anesthetized dogs /
[ Majid DS;Godfrey M;Grisham MB;Navar LG ] / Hypertens   DOI
44 Nitric oxide regulates renal hemo- dynamics and urinary sodium excretion in dogs /
[ Manning RD Jr;Hu L ] / Hypertens   DOI
45 Renal and vascular nitric oxide system in reduced renal mass saline hypertension /
[ Arranz C;Tomat A;Fellet A;Garcia J;Balaszczuk AM;Costa M ] / Nephron Physiol   DOI   ScienceOn
46 /
[ Phillips RA.;Peter JP;Vanslyke DD(Eds.) ] / In Quantitative Clinical Chemistry Methods
47 Mineralocorticoid effects on Na,K-ATPase in individual nephron segments /
[ Garg LC;Knepper MA;Burg MB ] / Am J Physiol
48 /
[ 김종규 ] / 생리학
49 /
[ 김광진;김창주;김형진;박사훈 ] / 인체 생리학
50 /
[ 서울대학교 의과대학 ] / 전정판 신장학
51 The localization of the Na+,K+-ATPase in the cells of rat kidney cortex. A study on isolated plasma membranes /
[ Kinne R;Schmitz JE;Kinne-Saffran E ] / Pflugers Arch   DOI   ScienceOn
52 Induction of Na,K-ATPase in the proximal and distal convolution of the rat nephron after uninephrectomy /
[ Schmidt U;Dubach UC ] / Pflugers Arch
53 Na,K-ATPase /
[ Lingrel JB;Kuntzweiler T ] / J Biol Chem
54 Tissue-specific and developmental egulation of rat Na,K-ATPase catalytic alpha isoform and beta subunit mRNAs /
[ Orlowski J, Lingrel JB ] / J Biol Chem
55 /
[ 錢乙 ] / 小兒藥證直訣
56 Dietary sodium affects systemic and renal hemodynamic response to NO inhibition in healthy humans /
[ Bech JN;Nielsen CB;Ivarsen P;Jensen KT;Pedersen EB ] / Am J Physiol   DOI
57 Endogenous nitric oxide synthesis determines sensitivity to the pressor effect of salt /
[ Tolins J.P.;Shultz P.J. ] / Kidney Internat   DOI   ScienceOn
58 /
[ 中國中醫 硏究員 ] / 正統 金塊要
59 /
[ 康舜洙 ] / 바른 方劑學