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Effects of Kamiguibi-tang on Learning Ability of Ehtanol-induced Rats  

Lee Sang Ryong (College of Oriental Medicine, Woosuk University)
Cui Xun (Department of Oriental Pharmacy, Woosuk University)
Lim Jong Pil (Department of Oriental Pharmacy, Woosuk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.4, 2003 , pp. 1050-1053 More about this Journal
Abstract
This study was carried out to investigate effects of Kamiguibi-tang extract on learning ability of ethanol-treated rats. The rats were divided into 3 groups; normal, control and sample group. Control group administered ethanol at a dose of 3g/kg bw.(25 v/v %), while sample group administered the Kamiguibi-tang extract(200mg/kg) 30 min. before treating same dose of ethanol as control group orally. All groups were subjected to trials of straight channel on the 1 st day and to those of multiple T-maze during the following 3 days. The time required in normal group for the straight or T-maze of the 2nd and 3rd trials was significantly shorter than that of the 1 st, while the control group showed no significance. But in the straight channel or multiple T-maze trials, the sample group showed significant decrease in the time required against the control group and also showed significant decrease in the number of selecting errors.
Keywords
Kamiguibi-tang(加味歸脾湯); Learning; Ability; T-maze; Ethanol;
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