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Effects of Bulbus Allii Macrostemi Extract on PKC activity in Pulmonary Vascular Endothelial Cells Damaged by XO/HX  

Kwon Kang Beom (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Lee Ho Seung (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kang Gil Seong (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kim In Seob (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Ryu Do Gon (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.2, 2003 , pp. 443-446 More about this Journal
Abstract
To investigate the protective effect of Bulbus Allii Macrostemi (BAM) on the damage by pulmonary vascular endothelial cells by xanthine oxidase (XO)/hypoxanthine (HX)-induced oxygen free radical, Neutral Red (NR) and protein kinase c (PKC) activity assay were used. The results were obtained as follows ; The viability of vascular endothelial cells treated with XO/HX was decreased. And activation of PKC represented a maximal increase in group treated with XO/HX for 15 mins in vasvular pulmonary endothelial cells. But pretreated groups with BAM extracts were not inhibited the increase of PKC activation by XO/HX in a dose-dependent fashion. These results show that XO/HX elicits toxic effects in cultured pulmonary vascular endothelial cells, and suggest that BAM extract is very effective in the prevention of XO/HX-induced PKC activation.
Keywords
Bulbus Allii Macrostemi; Neutral Red (NR); protein kinase c (PKC); xanthine oxidase (XO)/hypoxanthine (HX);
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Times Cited By KSCI : 1  (Citation Analysis)
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