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Vasodilation Effect of the Water Extract of Alcohol Processed Rheum palmatum L. in Rat Thoracic Aorta  

Kim Hyung Hwan (College of Oriental Medicine. Kyung Hee University)
Koo Bon Sik (College of Oriental Medicine. Kyung Hee University)
Lee Eun Ju (College of Oriental Medicine. Kyung Hee University)
Ahn Duk kyun (Jaseng research institute of biotechnology & bioscience)
Park Seong Kyu (College of Oriental Medicine. Kyung Hee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.5, 2002 , pp. 938-942 More about this Journal
Abstract
We have examined the relaxational response to the water extract of Rheum palmatum L.(ERP) and water extrc alcohol processed Rheum palmatum L.(ARP) in isolated thoracic aorta from sprague dawley (SD) rat. Rat thoracic aort investigated in vessel segments suspended for isometric tension recording by polygraph. Responses to ERP and ARP investigated in vessels precontracted with 5-hydroxytryptamine(5-HT). We found that the thoracic aorta segments respo to ERP and ARP with a dose-dependent vasorelaxation. We found that ; The thoracic aorta segments responded to I and ARP with a dose-dependent vasodilation. The 5-HT induced contraction at 10/sup -4/M were inhibited by 71.7% and a: after addition of the 0.01 g/mL water extract of ERP and ARP. The 5-HT induced contraction at 10/sup -4/M were inhibite 100% after 10/sup -3/M emodin. The concentration of emodin was 0.027% and 0.098% in ERP and ARP. In condusion, ERP ARP induced relaxation in the isolated rat thoracic aorta were composed of dose-dependent relaxation. and it has pi vasodilation.
Keywords
Rheum palmatum L.; alcohol processed Rheum palmatum L.(ARP); endothelium; polygraph; 5-hydroxytryptamine(5-HT); vasodilation; emodin;
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[ 金頀哲 ] / 韓藥藥理學
2 大黃의 起源에 대한 연구 /
[ 鄭大圭 ] / 東西醫學
3 /
[ 黃國健(編) ] / 中醫單方應用大全
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[ 李時珍 ] / 本草綱目
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[ 國家中醫藥管理局 <中華本草> 編委會 ] / 中華本草
6 /
[] / 韓國本草圖鑑
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[ 지형준(편저) ] / 한약규격주해
8 /
[ 江蘇新醫學阮編 ] / 中藥大辭典
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[ 苗明三(主編) ] / 法定中藥藥理與臨床
10 /
[ 鄭虎占(等主編) ] / 中藥現代硏究與應用
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[ 國家藥典委員會(編) ] / 中華人民共和國 藥典
12 The relaxational response to the water extract of Rheum palmatum L. and its components in rat thoracic aorta. /
[ Kim H. H.;Ahn D. K.;Park S.K. ] / Journal of Oriental Medicine
13 當歸의 종류에 따른 四物湯이 白鼠의 흉부대동맥 혈관이완에 미치는 영향 /
[ 朴性奎 ] / 대한본초학회지
14 /
[ 원도희 ] / 상용 생약의 성분정량
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[ 이영노 ] / 原色韓國植物圖鑑
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[ 全國韓醫科大學敎授(編) ] / 本草學