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Study on the Effect of Flos Carthami on Cultured Osteoblasts Damaged by Methylmercuric Chloride  

Min Bu Ki (School of Medicine, Wonkwang University)
Hong Gi Youn (School of Medicine, Wonkwang University)
Oh Yeon Kyun (School of Medicine, Wonkwang University)
Shin Yong Il (School of Medicine, Wonkwang University)
Han Sun Hee (Wonkwang health Science College)
Lee Sang Bork (Wonkwang health Science College)
Shin Min Kyo (College of Oriental Medicine, Wonkwang University)
Jeon Byung Hoon (College of Oriental Medicine, Wonkwang University)
Song Ho Jun (College of Oriental Medicine, Wonkwang University)
Ryu Do Gon (College of Oriental Medicine, Wonkwang University)
Park Seung Taeck (School of Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.4, 2002 , pp. 764-767 More about this Journal
Abstract
To evaluate the osteotoxic effect of methylmercuric chloride(MMC) on cultured mouse osteoblasts, cytotoxic effect was measured by MTT assay after cultured mouse osteoblasts were incubated with various concentrations of MMC for 20 hours. The protective effect of Flos Carthami(FC) against MMC-induced osteotoxicity was also examined in these cultures. MMC decreased cell viability of cultured mouse osteoblasts remarkably in a dose- and time-dependent manners. In protective effect of FC was remarkably effective in blocking the osteotoxicity induced by MMC. From aboved the results, it is suggested that MMC induce osteotoxicity, and the selective herba extract such as FC is very effective in blocking MMC-mediated neurotoxicity on cultured mouse osteoblasts.
Keywords
Methylmercuric chloride; Cultured osteoblast; Flos carthami;
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