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Mechanism of Jaeumgenby-tang on the Regional Cerebral Blood Flow, Mean Arterial Blood Pressure and Cardiac Muscle Contractile Force in Rats  

Jeong Hyun Woo (Department of Pathology, College of Oriental Medicine, Dongshin University)
Kim Hee Seong (Department of Pathology, College of Oriental Medicine, Dongshin University)
Yang Gi Ho (Department of Pathology, College of Oriental Medicine, Dongshin University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.3, 2002 , pp. 507-513 More about this Journal
Abstract
Jaeumgenby-tang(JGT) have been used in oriental medicine for many centries as a a therapeutic agent of vertigo caused by deficiency of qi and blood. The effects of JGT on the regional cerebral blood flow(rCBF), mean arterial blood pressure(MABP) and cardiac muscle contractile force(CMF) is not known. The purpose of this Study was to investigate effects of JGT on the rCBF, MABP, CMF and mechanism of JGT induced changed rCBF, MABP, CMF. The changes of rCBF, MABP and CMF were determinated by Laser-Doppler Flowmetry(LDF). The results were as follows; JGT extract was increased rCBF, MABP and CMF in a dose-dependent, specially JGT extract was significantly increased rCBF and MABP. Pretreatment with propranolol was significantly inhibited JGT induced increase of rCBF but pretreatment with indomethacin and methylene blue were accelerated JGT induced increase of rCBF. Pretreatment with propranolol and indomethacin were inhibited JGT induced increase of MABP, but pretreatment with methylene blue was accelerated JGT induced increase of MABP. Pretreatment with propranolol was significantly inhibited JGT induced increase of CMF but pretreatment with indomethacin and methylene blue were accelerated JGT induced increase of CMF. This results suggest that JGT increased rCBF by increasing MABP and CMF and the action of JGT is mediated by adrenergic β-receptor.
Keywords
Jaeumgenby-tang(滋陰健脾湯); regional cerebral blood flow; mean arterial blood pressure; cardiac muscle contractile force; Laser-Doppler Flowmetry; adrenergic β-receptor;
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