Browse > Article

Effect of Bee Venom Ointment Treatment for Chemotherapy-induced Peripheral Neuropathy : A Case Series  

Park, Byung-Rok (East-West Cancer Center, Dun-San Korean Medical Hospital of Daejeon University)
Kim, Jong-Min (East-West Cancer Center, Dun-San Korean Medical Hospital of Daejeon University)
Cho, Chong-Kwan (East-West Cancer Center, Dun-San Korean Medical Hospital of Daejeon University)
Shin, Seong-Hoon (Department of Internal Medicine, Kosin University College of Medicine)
Yoo, Hwa-Seung (East-West Cancer Center, Dun-San Korean Medical Hospital of Daejeon University)
Publication Information
Journal of Haehwa Medicine / v.22, no.2, 2014 , pp. 111-117 More about this Journal
Abstract
Objective : This is a case series reporting degree of response to bee venom ointment as a symptom-control therapy for chemotherapy-induced peripheral neuropathy (CIPN). Methods : Four consecutive patients with CIPN were referred to the East-West Cancer Center from October 7th, 2013, to November 9th, 2013. Patients with CIPN were treated with bee venom ointment 1-2 times per day for 7-25 days. Visual Analog Score (VAS) pain scale was compared before and after treatment. All patients were closely examined for any allergenic responses following each treatment session. Results : Using each patient as their own comparator, marked improvements of VAS were observed in 4 patients. Most important, there were no related adverse side effects found. Conclusion : Bee venom Ointment may be considered as an complementary therapy for managing CIPN symptoms.
Keywords
bee venom ointment; chemotherapy-induced peripheral neuropathy; visual analog score;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Mielke S, Sparreboom A, Mross K. Peripheral neuropathy: A persisting challenge in paclitaxel-based regimes. Eur J Cancer, 42(1):24-30, 2006.   DOI   ScienceOn
2 Gamelin L, Boisdron-Celle M, Delva R, Guerin-Meyer V, Ifrah N, Morel A, et al. Prevention of oxaliplatin-related neurotoxicity by calcium and magnesium infusions: A retrospective study of 161 patients receiving oxaliplatin combined with 5-fluorouracil and leucovorin for advanced colorectal cancer. Clin Cancer Res 15;10(12 Pt 1):4055-4061, 2004.   DOI   ScienceOn
3 Ling B, Authier N, Balayssac D, Eschalier A, Coudore F. Behavioral and pharmacological description of oxaliplatin-induced painful neuropathy in rat. Pain, 128(3):225-234, 2007.   DOI   ScienceOn
4 Marchand F, Alloui A, Chapuy E, Jourdan D, Pelissier T, Ardid D, et al. Evidence for a monoamine mediated, opioid-independent, antihyperalgesic effect of venlafaxine, a non-tricyclic antidepressant, in a neurogenic pain model in rats. Pain, 103(3):229-235, 2003.   DOI
5 Park MJ, Yeam SR, Kwon YD. The effects of bee venom therapy with different dose in neuropathic pain rat model. J Oriental Rehab Med, 22(4):79-89, 2012.
6 Lim BS, Moon HJ, Li DX, Gil M, Min JK, Lee G, et al. Effect of bee venom acupuncture on oxaliplatin-induced cold allodynia in rats. Evid Based Complement Alternat Med Article ID, 369324, 2013.
7 Park JW, Jeon JH, Yoon J, Jung TY, Kwon KR, Cho CK, et al. Effects of sweet bee venom pharmacopuncture treatment for chemotherapy-induced peripheral neuropathy: A case series. Integr Cancer Ther, 11(2):166-171, 2012.   DOI   ScienceOn
8 Yoon JW, Jeon JH, Lee YW, Cho CK, Kwon KR, Shin JE, et al. Sweet bee venom pharmacopuncture for chemotherapy-induced peripheral neuropathy. J Acupunct Meridian Stud, 5(4):156-165, 2012.   DOI
9 Wolf S, Barton D, Kottschade L, Grothey A, Loprinzi C. Chemotherapy-induced peripheral neuropathy: Prevention and treatment strategies. Eur J Cancer, 44(11):1507-1515, 2008.   DOI   ScienceOn
10 Amptoulach S, Tsavaris N. Neurotoxicity caused by the treatment with platinum analogues. Chemother Res Pract Article ID, 843019, 2011.
11 Argyriou AA, Koltzenburg M, Polychronopoulos P, Papapetropoulos S, Kalofonos HP. Peripheral nerve damage associated with administration of taxanes in patients with cancer. Crit Rev Oncol Hematol, 66(3):218-228, 2008.   DOI   ScienceOn
12 Gutierrez-Gutierrez G, Sereno M, Miralles A, Casado-Saenz E, Gutierrez-Rivas E. Chemotherapy-induced peripheral neuropathy: Clinical features, diagnosis, prevention and treatment strategies. Clin Transl Oncol, 12(2):81-91, 2010.   DOI
13 Van den Bent MJ, Van Raaij-van den Aarssen VJ, Verweij J, Doorn PA, Sillevis Smitt PA. Progression of paclitaxel-induced neuropathy following discontinuation of treatment. Muscle Nerve, 20(6):750-752, 1997.   DOI