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A Case of Gastric Low-grade MALT Lymphoma Induced by a Helicobacter heilmannii-like Organism  

Oh, Dong-Hoon (Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine)
Kim, Nam-Hoon (Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine)
Cho, Yu-Jung (Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine)
Song, Tae-Jun (Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine)
Bae, Won-Ki (Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine)
Kim, Kyung-Ah (Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine)
Lee, June-Sung (Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine)
Joo, Mee (Department of Pathology, Ilsan Paik Hospital, Inje University College of Medicine)
Publication Information
Clinical Endoscopy / v.43, no.1, 2011 , pp. 25-29 More about this Journal
Abstract
Helicobacter heilmannii is a Gram negative, long spiral-shaped organism associated with zoonotic infections acquired from primates including cats and dogs. Infection with H. heilmannii leads to gastritis, peptic ulcer disease, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. We experienced a 54-year-old man with dyspepsia who was diagnosed with primary gastric MALT lymphoma (stage IE1) associated with a H. heilmannii-like organism. Upper gastrointestinal endoscopy revealed only microvascular dilatation and mucosal granularity without elevated or ulcerative lesions at the stomach angle. He was probably infected by a pet dog. The man was treated with eradication therapy for 2 weeks including lansoprazole, amoxicillin, and clarithromycin. Four weeks after eradication of the H. heilmannii-like organism, follow-up endoscopy and pathological biopsy findings showed complete remission of the gastric MALT lymphoma.
Keywords
Helicobacter heilmannii; Helicobacter pylori; Gastric MALT lymphoma;
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1 Parsonnet J, Friedman GD, Vandersteen DP, et al. Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med 1991;325:1127-1131.   DOI   ScienceOn
2 Wotherspoon AC, Ortiz-Hidalgo C, Falzon MR, Isaacson PG. Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet 1991;338:1175-1176.   DOI   ScienceOn
3 Eaton KA, Dewhirst FE, Paster BJ, et al. Prevalence and varieties of Helicobacter species in dogs from random sources and pet dogs: animal and public health implications. J Clin Microbiol 1996;34:3165-3170.
4 Heilmann KL, Borchard F. Gastritis due to spiral shaped bacteria other than Helicobacter pylori: clinical, histological, and ultrastructural findings. Gut 1991;32:137-140.   DOI   ScienceOn
5 Hilzenrat N, Lamoureux E, Weintrub I, Alpert E, Lichter M, Alpert L. Helicobacter heilmannii-like spiral bacteria in gastric mucosal biopsies. Prevalence and clinical significance. Arch Pathol Lab Med 1995;119:1149-1153.
6 Andersen LP, Norgaard A, Holck S, Blom J, Elsborg L. Isolation of a "Helicobacter heilmannii"-like organism from the human stomach. Eur J Clin Microbiol Infect Dis 1996;15:95-96.   DOI   ScienceOn
7 Jhala D, Jhala N, Lechago J, Haber M. Helicobacter heilmannii gastritis: association with acid peptic diseases and comparison with Helicobacter pylori gastritis. Mod Pathol 1999;12:534-538.
8 Okiyama Y, Matsuzawa K, Hidaka E, Sano K, Akamatsu T, Ota H. Helicobcater heilmannii infection: clinical, endoscopic and histological features in Japanese patients. Pathol Int 2005;55:398-404.   DOI   ScienceOn
9 Joo M, Kwak JE, Chang SH, et al. Helicobacter heilmanniiassociated gastritis: clinicopathologic findings and comparison with Helicobacter pylori-associated gastritis. J Korean Med Sci 2007;22:63-69.
10 Morgner A, Bayerdorffer E, Meining A, Stolte M, Kroher G. Helicobacter heilmannii and gastric cancer. Lancet 1995;346:511-512.
11 Thomas-Marques L, Yaziji N, Bouche O, Diebold MD, Cadiot G, Thiefin G. Helicobacter heilmannii-associated low-grade gastric MALT lymphoma: a new case of complete remission after eradication. Gastroenterol Clin Biol 2005;29:476-477.   DOI   ScienceOn
12 Regimbeau C, Karsenti D, Durand V, et al. Low-grade gastric MALT lymphoma and Helicobacter heilmannii (Gastrospirillum hominis). Gastroenterol Clin Biol 1998;22:720-723.
13 Stolte M, Wellens E, Bethke B, Ritter M, Eidt H. Helicobacter heilmannii (formerly Gastrospirillum hominis) gastritis: an infection transmitted by animals? Scand J Gastroenterol 1994;29:1061-1064.   DOI   ScienceOn
14 Hwang CY, Han HR, Youn HY. Prevalence and clinical characterization of gastric Helicobacter species infection of dogs and cats in Korea. J Vet Sci 2002;3:123-133.
15 Morgner A, Lehn N, Andersen LP, et al. Helicobacter heilmannii- associated primary gastric low-grade MALT lymphoma: complete remission after curing the infection. Gastroenterology 2000;118:821-828.   DOI   ScienceOn
16 O'Rourke JL, Dixon MF, Jack A, Enno A, Lee A. Gastric B-cell mucosa-associated lymphoid tissue (MALT) lymphoma in an animal model of 'Helicobacter heilmannii' infection. J Pathol 2004;203:896-903.   DOI   ScienceOn
17 Nakamura M, Takahashi S, Matsui H, et al. Microcirculatory alteration in low-grade gastric mucosa-associated lymphoma by Helicobacter heilmannii infection: its relation to vascular endothelial growth factor and cyclooxygenase-2. J Gastroenterol Hepatol 2008;23(suppl):157S-160S.
18 Trebesius K, Adler K, Vieth M, Stolte M, Haas R. Specific detection and prevalence of Helicobacter heilmannii-like organisms in the human gastric mucosa by fluorescent in situ hybridization and partial 16S ribosomal DNA sequencing. J Clin Microbiol 2001;39:1510-1516.   DOI   ScienceOn
19 Matsui H, Aikawa C, Sekiya Y, Takahashi S, Murayama SY, Nakamura M. Evaluation of antibiotic therapy for eradication of "Candidatus Helicobacter heilmannii". Antimicrob Agents Chemother 2008;52:2988-2989.   DOI   ScienceOn