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Olibanum Extract Inhibits Vascular Smooth Muscle Cell Migration and Proliferation in Response to Platelet-Derived Growth Factor  

Choi, Ok-Byung (Department of Cosmetic Science, College of Natural Science, Hoseo University)
Park, Joo-Hoon (Department of Cosmetic Science, College of Natural Science, Hoseo University)
Lee, Ye-Jin (Department of Cosmetic Science, College of Natural Science, Hoseo University)
Lee, Chang-Kwon (Department of Physiology, School of Medicine, Konkuk University)
Won, Kyung-Jong (Department of Physiology, School of Medicine, Konkuk University)
Kim, Jung-Hwan (Department of Physical Therapy, College of Health & Welfare, Yongin University)
Lee, Hwan-Myung (Department of Cosmetic Science, College of Natural Science, Hoseo University)
Kim, Bo-Kyung (Department of Physiology, School of Medicine, Konkuk University)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.13, no.2, 2009 , pp. 107-113 More about this Journal
Abstract
Olibanum (Boswellia serrata) has been shown to have anti-inflammatory, anti-arthritic and anticancer effects. This study determined the role of a water extract of olibanum in platelet-derived growth factor (PDGF)-stimulated proliferation and migration of rat aortic smooth muscle cells (RASMCs). PDGF-BB induced the migration and proliferation of RASMCs that were inhibited by olibanum extract in a dose-dependent manner. The PDGF-BB-increased phosphorylation of p38 mitogen-activated protein kinase (MAPK); the heat shock protein (Hsp) 27 was significantly inhibited by the olibanum extract. The effects of PDGF-BB-induced extracellular signal-regulated kinase1/2 was not altered by the olibanum extract. Treatment with olibanum extract inhibited PDGF-BB-stimulated sprout out growth of aortic rings. These results suggest that the water extract of olibanum inhibits PDGF-BB-stimulated migration and proliferation in RASMCs as well as sprout out growth, which may be mediated by the inhibition of the p38 MAPK and Hsp27 pathways.
Keywords
Olibanum; Migration; Proliferation; Rat aortic smooth muscle cells; Mitogen-activated protein kinase;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 1  (Related Records In Web of Science)
Times Cited By SCOPUS : 2
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