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http://dx.doi.org/10.17480/psk.2016.60.3.107

Inhibitory Activities of 1,5-Diarylimidazole Derivatives with Methylthiophenyl Group against PGE2 Production  

Kwon, Jae-Hyun (School of Medicine, Kangwon National University)
Park, Haeil (College of Pharmacy, Kangwon National University)
Kim, Sung-Soo (School of Medicine, Kangwon National University)
Publication Information
YAKHAK HOEJI / v.60, no.3, 2016 , pp. 107-111 More about this Journal
Abstract
Inhibitory activities of 1,5-diarylimidazole analogs with methylthiophenyl group on prostaglandin $E_2$ ($PGE_2$) production from LPS-treated RAW 264.7 cells, were evaluated and compared with those of the corresponding analogs with 4-methanesulfonylphenyl group. Among the tested nineteen analogs with methylthiophenyl group, fourteen analogs showed strong inhibitory activities (>88%) when compared with the reference compound NS-398, and fifteen analogs have similar inhibitory activities with those of parent analogs with 4-methanesulfonylphenyl group. Those results suggest that most of 1,5-diarylimidazole analogs with methanesulfonylphenyl group can be also active even after they are metabolized by reduction.
Keywords
1,5-diarylimidazole; inflammation; 4-methylthiophenyl; prostaglandin $E_2$;
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Times Cited By KSCI : 1  (Citation Analysis)
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