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Screening of Arachidonic Acid Cascade Related Enzymes Inhibitors from Korean Indigenous Plants (2)  

정혜진 (영남대학교 약학대학)
문태철 (영남대학교 약학대학)
이은경 (영남대학교 약학대학)
손건호 (안동대학 식품영양학과)
김현표 (강원대학 약학대학)
강삼식 (서울대학교 천연물과학연구소)
배기환 (충남대학교 약학대학)
안인파 (충남대학교 약학대학)
권동렬 (원광대학교 약학대학 한약학과)
Publication Information
YAKHAK HOEJI / v.47, no.2, 2003 , pp. 69-77 More about this Journal
Abstract
Arachidonic acid (AA), which is stored in membrane glycerophospholipids, is liberated by phospholipase $A_2$ (PLA$_2$) enzymes and is sequentially converted to cyclooxygenases (COXs) and lipoxygenases (LOXs) then to various bioactive PGs, and LTs. In order to find the specific inhibitors of AA metabolism especially PLA$_2$, COX-2, 5-LO and lyso PAF acetyltransferase, 120 Korean residential plants extracts were evaluated for their inhibitory activity on PGD$_2$, LTC$_4$ production from cytokine-induced mouse bone marrow-derived mast cells (BMMC) and arachidonic acid released from phospholipid and PAF production from lyso PAF. From this screening procedure, methanol extract of ten indigenous plant such as Salix gracilistyla, Sedum kamtschaticum, Cirsium chanroenicum, Hypericum ascyron, Astilbe chinensis, Agrimonia pilosa, Aristolochia manshuriensis, Vodia daniellii, Pyrola japonica, Styrax obassia were found to inhibit production of inflammatory mediators in vitro assay system.
Keywords
Secretory Phospholipase $A_2$; cyclooxygenase-2; 5-lipoxygenase; lyso PAF acetyltransferase; inhibitors; Korean indigenous plants; anti-inflammatory agents;
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Times Cited By KSCI : 3  (Citation Analysis)
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