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http://dx.doi.org/10.3904/kjim.2014.322

Opportunistic diseases among HIV-infected patients: a multicenter-nationwide Korean HIV/AIDS cohort study, 2006 to 2013  

Kim, Youn Jeong (Division of Infectious Disease, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea)
Woo, Jun Hee (Department of Infectious Disease, Asan Medical Center, University of Ulsan College of Medicine)
Kim, Min Ja (Department of Internal Medicine, Korea University College of Medicine)
Park, Dae Won (Department of Internal Medicine, Korea University College of Medicine)
Song, Joon-Young (Department of Internal Medicine, Korea University College of Medicine)
Kim, Shin Woo (Department of Internal Medicine, Kyungpook National University School of Medicine)
Choi, Jun Yong (Department of Internal Medicine, Yonsei University College of Medicine)
Kim, June Myung (Department of Internal Medicine, Yonsei University College of Medicine)
Han, Sang Hoon (Department of Internal Medicine, Yonsei University College of Medicine)
Lee, Jin-Soo (Department of Internal Medicine, Inha University School of Medicine)
Choi, Bo Youl (Department of Preventive Medicine, Hanyang University College of Medicine)
Lee, Joo Shil (Korea Centers for Disease Control and Prevention)
Kim, Sung-Soon (Korea Centers for Disease Control and Prevention)
Kee, Mee-Kyung (Korea Centers for Disease Control and Prevention)
Kang, Moon Won (Division of Infectious Disease, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea)
Kim, Sang Il (Division of Infectious Disease, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea)
Publication Information
The Korean journal of internal medicine / v.31, no.5, 2016 , pp. 953-960 More about this Journal
Abstract
Background/Aims: The frequencies of opportunistic diseases (ODs) vary across countries based on genetic, environmental, and social differences. The Korean HIV/AIDS cohort study was initiated in 2006 to promote research on human immunodeficiency virus (HIV) infection in Korea, and to provide a logistical network to support multicenter projects on epidemiological, clinical, and laboratory aspects of HIV infection. This study evaluated the prevalence of ODs among HIV-infected patients in the era of highly active antiretroviral therapy, and the risk factors associated with ODs. Methods: The study enrolled 1,086 HIV-infected patients from 19 hospitals. This study examined the baseline data of the HIV/AIDS Korean cohort study at the time of enrollment from December 2006 to July 2013. Results: Candidiasis was the most prevalent opportunistic infection (n = 176, 16.2%), followed by Mycobacterium tuberculosis infection (n = 120, 10.9%), Pneumocystis jirovecii pneumonia (n = 121, 11.0%), cytomegalovirus infection (n = 52, 4.7%), and herpes zoster (n = 44, 4.0%). The prevalence rates of Kaposi's sarcoma (n = 8, 0.7%) and toxoplasmosis (n = 4, 0.4%) were very low compared with other countries. The risk factors for ODs were a low CD4 T cell count at the time of HIV diagnosis (odds ratio [OR], 1.01; p < 0.01), current smoking (OR, 2.27; p = 0.01), current alcohol use (OR, 2.57; p = 0.04), and a history of tuberculosis (OR, 5.23; p < 0.01). Conclusions: Using recent Korean nationwide data, this study demonstrated that an important predictor of ODs was a low CD4 T cell count at the time of HIV diagnosis. Tuberculosis remains one of the most important ODs in HIV-infected patients in Korea.
Keywords
AIDS-related opportunistic infections; HIV; Korea; Tuberculosis;
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