[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.3904/kjim.2015.30.5.580

Mesenchymal stem cell therapy for liver fibrosis

Eom, Young Woo (Cell Therapy and Tissue Engineering Center)
Shim, Kwang Yong (Department of Internal Medicine, Yonsei University Wonju College of Medicine)
Baik, Soon Koo (Cell Therapy and Tissue Engineering Center)

Publication Information

The Korean journal of internal medicine / v.30, no.5, 2015 , pp. 580-589 More about this Journal

Abstract

Currently, the most effective treatment for end-stage liver fibrosis is liver transplantation; however, transplantation is limited by a shortage of donor organs, surgical complications, immunological rejection, and high medical costs. Recently, mesenchymal stem cell (MSC) therapy has been suggested as an effective alternate approach for the treatment of hepatic diseases. MSCs have the potential to differentiate into hepatocytes, and therapeutic value exists in their immune-modulatory properties and secretion of trophic factors, such as growth factors and cytokines. In addition, MSCs can suppress inflammatory responses, reduce hepatocyte apoptosis, increase hepatocyte regeneration, regress liver fibrosis and enhance liver functionality. Despite these advantages, issues remain; MSCs also have fibrogenic potential and the capacity to promote tumor cell growth and oncogenicity. This paper summarizes the properties of MSCs for regenerative medicine and their therapeutic mechanisms and clinical application in the treatment of liver fibrosis. We also present several outstanding risks, including their fibrogenic potential and their capacity to promote pre-existing tumor cell growth and oncogenicity.

Keywords

Liver cirrhosis; Mesenchymal stromal cells; Immune modulation; Trophic factors; Anti-fibrosis;

Citations & Related Records

Times Cited By KSCI : 2 (Citation Analysis)

Reference
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None	(2021) PPAR research Apigenin Alleviates Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Autophagy via TGF-β1/Smad3 and p38/PPARα Pathways / 2021 (None) , 1
None	(2015) Drug design, development and therapy Taxifolin, Extracted from Waste Larix olgensis Roots, Attenuates CCl4-Induced Liver Fibrosis by Regulating the PI3K/AKT/mTOR and TGF-β1/Smads Signaling Pathways / 15 (None) , 871
None	(2015) Frontiers in immunology Mesenchymal Stromal Cell-Derived Extracellular Vesicles Regulate the Mitochondrial Metabolism via Transfer of miRNAs / 12 (None) , 623973
None	(2021) Frontiers in immunology Macrophage Polarization and Its Role in Liver Disease / 12 (None) , 803037
None	(2015) Frontiers in cell and developmental biology Regulatory T Cells Improved the Anti-cirrhosis Activity of Human Amniotic Mesenchymal Stem Cell in the Liver by Regulating the TGF-β-Indoleamine 2,3-Dioxygenase Signaling / 9 (None) , 737825
None	(2021) Frontiers in cell and developmental biology Human Liver Stem Cell-Derived Extracellular Vesicles Target Hepatic Stellate Cells and Attenuate Their Pro-fibrotic Phenotype / 9 (None) , 777462
None	(2015) Frontiers in medicine Acute-on-Chronic Liver Failure: Pathophysiological Mechanisms and Management / 8 (None) , 752875
1	(2015) Biology bulletin reviews Regulatory Effect of Mesenchymal Stromal Cells on the Development of Liver Fibrosis: Cellular and Molecular Mechanisms and Prospects for Clinical Application / 11 (1) , 54
2	(2021) 3 Biotech Hepatoprotective effect of bone marrow-derived mesenchymal stromal cells in CCl <SUB>4</SUB> -induced liver cirrhosis / 11 (2) , 107
2	(2015) JGH open : an open access journal of gastroenterology and hepatology Can bone marrow‐derived mesenchymal stem cells change liver volume?: A case report / 5 (2) , 320
None	(2015) Materials today communications Recent advances in polymeric scaffolds containing carbon nanotube and graphene oxide for cartilage and bone regeneration / 26 (None) , 102097
5	(2015) Cell cycle Exosomes derived from autologous dermal fibroblasts promote diabetic cutaneous wound healing through the Akt/β-catenin pathway / 20 (5) , 616
3	(2015) Pediatric transplantation Co‐transplantation of bone marrow‐derived mesenchymal stem cells with hematopoietic stem cells does not improve transplantation outcome in class III beta‐thalassemia major: A prospec / 25 (3) , e13905
6	(2015) Omics : a journal of integrative biology Recent Trends in Multipotent Human Mesenchymal Stem/Stromal Cells: Learning from History and Advancing Clinical Applications / 25 (6) , 342
6	(2021) World journal of hepatology Wilson's disease: Revisiting an old friend / 13 (6) , 634
17	(2021) International journal of molecular sciences The Phosphonate Derivative of C60 Fullerene Induces Differentiation towards the Myogenic Lineage in Human Adipose-Derived Mesenchymal Stem Cells / 22 (17) , 9284
19	(2015) International journal of molecular sciences Cell-Based Regeneration and Treatment of Liver Diseases / 22 (19) , 10276
1	(2015) Journal of nanobiotechnology 3D hESC exosomes enriched with miR-6766-3p ameliorates liver fibrosis by attenuating activated stellate cells through targeting the TGFβRII-SMADS pathway / 19 (1) , 437
24	(2015) International journal of molecular sciences Regenerative Potential of Mesenchymal Stem Cells’ (MSCs) Secretome for Liver Fibrosis Therapies / 22 (24) , 13292