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http://dx.doi.org/10.3904/kjim.2014.29.4.482

Effects of pretransplant plasmapheresis and rituximab on recurrence of focal segmental glomerulosclerosis in adult renal transplant recipients  

Park, Hoon Suk (Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea College of Medicine)
Hong, Yuah (Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea College of Medicine)
Sun, In O (Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea College of Medicine)
Chung, Byung Ha (Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea College of Medicine)
Kim, Hyung Wook (Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea College of Medicine)
Choi, Bum Soon (Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea College of Medicine)
Park, Cheol Whee (Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea College of Medicine)
Jin, Dong Chan (Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea College of Medicine)
Kim, Yong Soo (Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea College of Medicine)
Yang, Chul Woo (Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea College of Medicine)
Publication Information
The Korean journal of internal medicine / v.29, no.4, 2014 , pp. 482-488 More about this Journal
Abstract
Background/Aims: Recurrent focal segmental glomerulosclerosis (FSGS) following renal transplantation is relatively common. However, the risk factors and optimal pretransplant treatment preventing recurrence of FSGS remain controversial. Methods: We retrospectively reviewed 27 adult renal transplant recipients with FSGS over a period of 10 years. We first compared possible risk factors for FSGS recurrence between the recurrence and nonrecurrence groups. Then we evaluated the effect of pretransplant plasmapheresis (PP; n = 4) and PP with rituximab (PP + RTX; n = 5) on recurrence of FSGS after transplantation compared to control patients that were not treated with these modalities. Results: There were seven recurrences in 27 patients (25.9%), but there were no significant differences in possible risk factors for FSGS recurrence between the two groups. Recurrence rates between patients with pretransplant PP or PP + RTX and control patients were not significantly different (22.2% vs. 27.7%, p > 0.05). There was also no significant difference in recurrence between the pretransplant PP and PP + RTX groups (25% vs. 20%, p > 0.05). Conclusions: Pretransplant PP or PP + RTX do not significantly decrease the recurrence of FSGS in adult renal transplant candidates.
Keywords
Rituximab; Plasmapheresis; Glomerulosclerosis, focal segmental; Recurrence; Kidney transplantation;
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Times Cited By KSCI : 1  (Citation Analysis)
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