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http://dx.doi.org/10.3904/kjim.2013.28.4.449

The start of chemotherapy until the end of radiotherapy in patients with limited-stage small cell lung cancer  

Lee, Kyoung Ju (Division of Respiratory and Allergy, Department of Internal Medicine, Daejin Medical Center)
Lee, Eun Joo (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University Medical Center)
Hur, Gyu Young (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University Medical Center)
Lee, Sang Yeub (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University Medical Center)
Kim, Je Hyeong (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University Medical Center)
Shin, Chol (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University Medical Center)
Shim, Jae Jeong (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University Medical Center)
In, Kwang Ho (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University Medical Center)
Kang, Kyung Ho (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University Medical Center)
Yoo, Se Hwa (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University Medical Center)
Lee, Sung Yong (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University Medical Center)
Publication Information
The Korean journal of internal medicine / v.28, no.4, 2013 , pp. 449-455 More about this Journal
Abstract
Background/Aims: Chemotherapy combined with radiation therapy is the standard treatment for limited stage small cell lung cancer (LS-SCLC). Although numerous studies indicate that the overall duration of chemoradiotherapy is the most relevant predictor of outcome, the optimal chemotherapy and radiation schedule for LS-SCLC remains controversial. Therefore we analyzed the time from the start of any treatment until the end of radiotherapy (SER) in patients with LS-SCLC. Methods: We retrospectively analyzed 29 patients diagnosed histologically with LS-SCLC and divided them into two groups: a short SER group (< 60 days) and a long SER (> 60 days) group. Patients were treated with irinotecan-based chemotherapy and thoracic radiotherapy. Results: Sixteen patients were in the short SER group and 13 patients were in the long SER group. Short SER significantly prolonged survival rate (p = 0.03) compared with that of long SER. However, no significant differences in side effects were observed. Conclusions: Short SER should be considered to improve the outcome of concurrent chemoradiotherapy for LS-SCLC.
Keywords
Small cell lung carcinoma; Limited-stage; Chemoradiotherapy; Start of any treatment until the end of radiotherapy;
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