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http://dx.doi.org/10.3904/kjim.2011.26.3.262

Impact of Air Pollution on Allergic Diseases  

Takizawa, Hajime (Department of Respiratory Medicine, Kyorin University School of Medicine)
Publication Information
The Korean journal of internal medicine / v.26, no.3, 2011 , pp. 262-273 More about this Journal
Abstract
The incidence of allergic diseases in most industrialized countries has increased. Although the exact mechanisms behind this rapid increase in prevalence remain uncertain, a variety of air pollutants have been attracting attention as one causative factor. Epidemiological and toxicological research suggests a causative relationship between air pollution and the increased incidence of asthma, allergic rhinitis, and other allergic disorders. These include ozone, nitrogen dioxide and, especially particulate matter, produced by traffic-related and industrial activities. Strong epidemiological evidence supports a relationship between air pollution and the exacerbation of asthma and other respiratory diseases. Recent studies have suggested that air pollutants play a role in the development of asthma and allergies. Researchers have elucidated the mechanisms whereby these pollutants induce adverse effects; they appear to affect the balance between antioxidant pathways and airway inflammation. Gene polymorphisms involved in antioxidant pathways can modify responses to air pollution exposure. While the characterization and monitoring of pollutant components currently dictates pollution control policies, it will be necessary to identify susceptible subpopulations to target therapy/prevention of pollution-induced respiratory diseases.
Keywords
Air pollutants; Antioxidant; Asthma; Vehicle emissions; Particulate matter;
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1 Li YJ, Kawada T, Matsumoto A, et al. Airway inflammatory responses to oxidative stress induced by low-dose diesel exhaust particle exposure differ between mouse strains. Exp Lung Res 2007;33:227-244.   DOI   ScienceOn
2 Li YJ, Kawada T, Takizawa H, et al. Airway inflammatory responses to oxidative stress induced by prolonged low-dose diesel exhaust particle exposure from birth differ between mouse BALB/c and C57BL/6 strains. Exp Lung Res 2008;34:125-139.   DOI   ScienceOn
3 Kang KW, Lee SJ, Kim SG. Molecular mechanism of nrf2 activation by oxidative stress. Antioxid Redox Signal 2005;7:1664-1673.   DOI   ScienceOn
4 Li YJ, Takizawa H, Azuma A, et al. Disruption of Nrf2 enhances susceptibility to airway inf lammatory responses induced by low-dose diesel exhaust particles in mice. Clin Immunol 2008;128:366-373.   DOI   ScienceOn
5 Li YJ, Takizawa H, Azuma A, et al. Nrf2 is closely related to allergic airway inflammatory responses induced by low-dose diesel exhaust particles in mice. Clin Immunol 2010;137:234-241.   DOI   ScienceOn
6 Li YJ, Takizawa H, Azuma A, et al. The effects of oxidative stress induced by prolonged low-dose diesel exhaust particle exposure on the generation of allergic airway inflammation differ between BALB/c and C57BL/6 mice. Immunopharmacol Immunotoxicol 2009;31:230-237.   DOI   ScienceOn
7 Rangasamy T, Guo J, Mitzner WA, et al. Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. J Exp Med 2005;202:47-59.   DOI   ScienceOn
8 Hashizume M, Ueda K, Nishiwaki Y, Michikawa T, Onozuka D. Health effects of Asian dust events: a review of the literature. Nihon Eiseigaku Zasshi 2010;65:413-421.   DOI   ScienceOn
9 Ichinose T, Yoshida S, Hiyoshi K, et al. The effects of microbial materials adhered to Asian sand dust on allergic lung inflammation. Arch Environ Contam Toxicol 2008;55:348-357.   DOI   ScienceOn
10 Ichinose T, Hiyoshi K, Yoshida S, et al. Asian sand dust aggravates allergic rhinitis in guinea pigs induced by Japanese cedar pollen. Inhal Toxicol 2009;21:985-993.   DOI   ScienceOn
11 Whitekus MJ, Li N, Zhang M, et al. Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization. J Immunol 2002;168:2560-2567.   DOI
12 Tashakkor AY, Chow KS, Carlsten C. Modification by antioxidant supplementation of changes in human lung function associated with air pollutant exposure: a systematic review. BMC Public Health 2011;11:532.   DOI
13 Eder W, Ege MJ, von Mutius E. The asthma epidemic. N Engl J Med 2006;355:2226-2235.   DOI   ScienceOn
14 Saxon A, Diaz-Sanchez D. Air pollution and allergy: you are what you breathe. Nat Immunol 2005;6:223-226.   DOI   ScienceOn
15 Takizawa H. Diesel exhaust particles and their effect on induced cytokine expression in human bronchial epithelial cells. Curr Opin Allergy Clin Immunol 2004;4:355-359.   DOI   ScienceOn
16 Terzano C, Di Stefano F, Conti V, Graziani E, Petroianni A. Air pollution ultrafine particles: toxicity beyond the lung. Eur Rev Med Pharmacol Sci 2010;14:809-821.
17 Dockery DW, Pope CA 3rd, Xu X, et al. An association between air pollution and mortality in six U.S. cities. N Engl J Med 1993;329:1753-1759.   DOI   ScienceOn
18 Schindler C, Keidel D, Gerbase MW, et al. Improvements in PM10 exposure and reduced rates of respiratory symptoms in a cohort of Swiss adults (SAPALDIA). Am J Respir Crit Care Med 2009;179:579-587.   DOI   ScienceOn
19 Bayer-Oglesby L, Grize L, Gassner M, et al. Decline of ambient air pollution levels and improved respiratory health in Swiss children. Environ Health Perspect 2005;113:1632-1637.   DOI   ScienceOn
20 McDonnell WF, Horstman DH, Hazucha MJ, et al. Pulmonary effects of ozone exposure during exercise: dose-response characteristics. J Appl Physiol 1983;54:1345-1352.   DOI
21 Kulle TJ, Sauder LR, Hebel JR, Chatham MD. Ozone response relationships in healthy nonsmokers. Am Rev Respir Dis 1985;132:36-41.
22 Kinney PL, Thurston GD, Raizenne M. The effects of ambient ozone on lung function in children: a reanalysis of six summer camp studies. Environ Health Perspect 1996;104:170-174.
23 Peters JM, Avol E, Gauderman WJ, et al. A study of twelve Southern California communities with differing levels and types of air pollution. II. Effects on pulmonary function. Am J Respir Crit Care Med 1999;159:768-775.   DOI   ScienceOn
24 Horvath SM, Gliner JA, Folinsbee LJ. Adaptation to ozone: duration of effect. Am Rev Respir Dis 1981;123:496-499.
25 Mudway IS, Kelly FJ. An investigation of inhaled ozone dose and the magnitude of airway inflammation in healthy adults. Am J Respir Crit Care Med 2004;169:1089-1095.   DOI   ScienceOn
26 Gauderman WJ, Avol E, Gilliland F, et al. The effect of air pollution on lung development from 10 to 18 years of age. N Engl J Med 2004;351:1057-1067.   DOI   ScienceOn
27 Ackermann-Liebrich U, Leuenberger P, Schwartz J, et al. Lung function and long term exposure to air pollutants in Switzerland: Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) Team. Am J Respir Crit Care Med 1997;155:122-129.   DOI   ScienceOn
28 Rosenlund M, Forastiere F, Porta D, De Sario M, Badaloni C, Perucci CA. Traffic-related air pollution in relation to respiratory symptoms, allergic sensitisation and lung function in schoolchildren. Thorax 2009;64:573-580.   DOI   ScienceOn
29 Avol EL, Gauderman WJ, Tan SM, London SJ, Peters JM. Respiratory effects of relocating to areas of differing air pollution levels. Am J Respir Crit Care Med 2001;164:2067-2072.   DOI   ScienceOn
30 Takizawa H. Airway epithelial cells as regulators of airway inflammation (Review). Int J Mol Med 1998;1:367-378.
31 Sheffield PE, Weinberger KR, Kinney PL. Climate change, aeroallergens, and pediatric allergic disease. Mt Sinai J Med 2011;78:78-84.   DOI   ScienceOn
32 Strand V, Svartengren M, Rak S, Barck C, Bylin G. Repeated exposure to an ambient level of NO2 enhances asthmatic response to a nonsymptomatic allergen dose. Eur Respir J 1998;12:6-12.   DOI   ScienceOn
33 Lipsett M, Hurley S, Ostro B. Air pollution and emergency room visits for asthma in Santa Clara County, California. Environ Health Perspect 1997;105:216-222.   DOI   ScienceOn
34 Gauderman WJ, Avol E, Lurmann F, et al. Childhood asthma and exposure to traffic and nitrogen dioxide. Epidemiology 2005;16:737-743.   DOI   ScienceOn
35 Tunnicliffe WS, Burge PS, Ayres JG. Effect of domestic concentrations of nitrogen dioxide on airway responses to inhaled allergen in asthmatic patients. Lancet 1994;344:1733-1736.   DOI   ScienceOn
36 Lin S, Liu X, Le LH, Hwang SA. Chronic exposure to ambient ozone and asthma hospital admissions among children. Environ Health Perspect 2008;116:1725-1730.   DOI   ScienceOn
37 Meng YY, Rull RP, Wilhelm M, Lombardi C, Balmes J, Ritz B. Outdoor air pollution and uncontrolled asthma in the San Joaquin Valley, California. J Epidemiol Community Health 2010;64:142-147.   DOI   ScienceOn
38 Gent JF, Triche EW, Holford TR, et al. Association of low-level ozone and fine particles with respiratory symptoms in children with asthma. JAMA 2003;290:1859-1867.   DOI   ScienceOn
39 Just J, Segala C, Sahraoui F, Priol G, Grimfeld A, Neukirch F. Short-term health effects of particulate and photochemical air pollution in asthmatic children. Eur Respir J 2002;20:899-906.   DOI   ScienceOn
40 Penttinen P, Vallius M, Tiittanen P, Ruuskanen J, Pekkanen J. Source-specific fine particles in urban air and respiratory function among adult asthmatics. Inhal Toxicol 2006;18:191-198.   DOI   ScienceOn
41 Escamilla-Nunez MC, Barraza-Villarreal A, Hernandez-Cadena L, et al. Traffic-related air pollution and respiratory symptoms among asthmatic children, resident in Mexico City: the EVA cohort study. Respir Res 2008;9:74.   DOI   ScienceOn
42 Balmes JR, Earnest G, Katz PP, et al. Exposure to traffic: lung function and health status in adults with asthma. J Allergy Clin Immunol 2009;123:626-631.   DOI   ScienceOn
43 McCreanor J, Cullinan P, Nieuwenhuijsen MJ, et al. Respiratory effects of exposure to diesel traffic in persons with asthma. N Engl J Med 2007;357:2348-2358.   DOI   ScienceOn
44 Zhang JJ, McCreanor JE, Cullinan P, et al. Health effects of real-world exposure to diesel exhaust in persons with asthma. Res Rep Health Eff Inst 2009;(138):5-109.
45 Takizawa H, Ohbayashi O, Azuma A, et al. The official report of Environmental Restoration and Conservation Agency of Japan. Kawasaki: Environmental Restoration and Conservation Agency of Japan, 2011.
46 Corradi M, Gergelova P, Mutti A. Use of exhaled breath condensate to investigate occupational lung diseases. Curr Opin Allergy Clin Immunol 2010;10:93-98.   DOI   ScienceOn
47 Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Lancet 1998;351:1225-1232.   DOI   ScienceOn
48 Ho SM. Environmental epigenetics of asthma: an update. J Allergy Clin Immunol 2010;126:453-465.   DOI   ScienceOn
49 Diaz-Sanchez D, Proietti L, Polosa R. Diesel fumes and the rising prevalence of atopy: an urban legend? Curr Allergy Asthma Rep 2003;3:146-152.   DOI   ScienceOn
50 Thornton CA, Macfarlane TV, Holt PG. The hygiene hypothesis revisited: role of materno-fetal interactions. Curr Allergy Asthma Rep 2010;10:444-452.   DOI   ScienceOn
51 Brauer M, Hoek G, Smit HA, et al. Air pollution and development of asthma, allergy and infections in a birth cohort. Eur Respir J 2007;29:879-888.   DOI   ScienceOn
52 Morgenstern V, Zutavern A, Cyrys J, et al. Atopic diseases, allergic sensitization, and exposure to traffic-related air pollution in children. Am J Respir Crit Care Med 2008;177:1331-1337.   DOI   ScienceOn
53 Nordling E, Berglind N, Melen E, et al. Traffic-related air pollution and childhood respiratory symptoms, function and allergies. Epidemiology 2008;19:401-408.   DOI   ScienceOn
54 Ryan PH, Bernstein DI, Lockey J, et al. Exposure to trafficrelated particles and endotoxin during infancy is associated with wheezing at age 3 years. Am J Respir Crit Care Med 2009;180:1068-1075.   DOI   ScienceOn
55 Shima M, Nitta Y, Ando M, Adachi M. Effects of air pollution on the prevalence and incidence of asthma in children. Arch Environ Health 2002;57:529-535.   DOI   ScienceOn
56 Gehring U, Wijga AH, Brauer M, et al. Traffic-related air pollution and the development of asthma and allergies during the first 8 years of life. Am J Respir Crit Care Med 2010;181:596-603.   DOI   ScienceOn
57 Braback L, Forsberg B. Does traffic exhaust contribute to the development of asthma and allergic sensitization in children: findings from recent cohort studies. Environ Health 2009;8:17.   DOI   ScienceOn
58 Kunzli N, Bridevaux PO, Liu LJ, et al. Traffic-related air pollution correlates with adult-onset asthma among never-smokers. Thorax 2009;64:664-670.   DOI   ScienceOn
59 Oftedal B, Nystad W, Brunekreef B, Nafstad P. Long-term traffic-related exposures and asthma onset in schoolchildren in oslo, norway. Environ Health Perspect 2009;117:839-844.   DOI
60 Anderson HR, Ruggles R, Pandey KD, et al. Ambient particulate pollution and the world-wide prevalence of asthma, rhinoconjunctivitis and eczema in children: Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC). Occup Environ Med 2010;67:293-300.   DOI   ScienceOn
61 McConnell R, Islam T, Shankardass K, et al. Childhood incident asthma and traffic-related air pollution at home and school. Environ Health Perspect 2010;118:1021-1026.   DOI   ScienceOn
62 Gilliland FD, Li YF, Saxon A, Diaz-Sanchez D. Effect of glutathione-S-transferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo-controlled crossover study. Lancet 2004;363:119-125.   DOI   ScienceOn
63 McConnell R, Berhane K, Yao L, et al. Traffic, susceptibility, and childhood asthma. Environ Health Perspect 2006;114:766-772.   DOI   ScienceOn
64 Gordian ME, Haneuse S, Wakefield J. An investigation of the association between traffic exposure and the diagnosis of asthma in children. J Expo Sci Environ Epidemiol 2006;16:49-55.   DOI   ScienceOn
65 Clougherty JE, Kubzansky LD. A framework for examining social stress and susceptibility to air pollution in respiratory health. Environ Health Perspect 2009;117:1351-1358.   DOI
66 Schroer KT, Biagini Myers JM, Ryan PH, et al. Associations between multiple environmental exposures and Glutathione S-Transferase P1 on persistent wheezing in a birth cohort. J Pediatr 2009;154:401-408, 408.e1.   DOI   ScienceOn
67 Clougherty JE, Levy JI, Kubzansky LD, et al. Synergistic effects of traffic-related air pollution and exposure to violence on urban asthma etiology. Environ Health Perspect 2007;115:1140-1146.   DOI   ScienceOn
68 Meng YY, Wilhelm M, Rull RP, English P, Nathan S, Ritz B. Are frequent asthma symptoms among low-income individuals related to heavy traffic near homes, vulnerabilities, or both? Ann Epidemiol 2008;18:343-350.   DOI   ScienceOn
69 Chen E, Schreier HM, Strunk RC, Brauer M. Chronic trafficrelated air pollution and stress interact to predict biologic and clinical outcomes in asthma. Environ Health Perspect 2008;116:970-975.   DOI   ScienceOn
70 Sienra-Monge JJ, Ramirez-Aguilar M, Moreno-Macias H, et al. Antioxidant supplementation and nasal inflammatory responses among young asthmatics exposed to high levels of ozone. Clin Exp Immunol 2004;138:317-322.   DOI   ScienceOn
71 Behndig AF, Blomberg A, Helleday R, Kelly FJ, Mudway IS. Augmentation of respiratory tract lining fluid ascorbate concentrations through supplementation with vitamin C. Inhal Toxicol 2009;21:250-258.   DOI   ScienceOn
72 Romieu I, Sienra-Monge JJ, Ramirez-Aguilar M, et al. Genetic polymorphism of GSTM1 and antioxidant supplementation influence lung function in relation to ozone exposure in asthmatic children in Mexico City. Thorax 2004;59:8-10.
73 Kelly FJ, Fussell JC. Air pollution and airway disease. Clin Exp Allergy 2011;41:1059-1071.   DOI   ScienceOn
74 Boland S, Baeza-Squiban A, Fournier T, et al. Diesel exhaust particles are taken up by human airway epithelial cells in vitro and alter cytokine production. Am J Physiol 1999;276(4 Pt 1):L604-L613.
75 Riedl M, Diaz-Sanchez D. Biology of diesel exhaust effects on respiratory function. J Allergy Clin Immunol 2005;115:221-228.   DOI   ScienceOn
76 Diaz-Sanchez D. The role of diesel exhaust particles and their associated polyaromatic hydrocarbons in the induction of allergic airway disease. Allergy 1997;52(38 Suppl):52-56.   DOI
77 Xu GB, Yu CP. Deposition of diesel exhaust particles in mammalian lungs: a comparison between rodents and man. Aerosol Sci Technol 1987;7:117-123.   DOI   ScienceOn
78 Ohtoshi T, Takizawa H, Okazaki H, et al. Diesel exhaust particles stimulate human airway epithelial cells to produce cytokines relevant to airway inflammation in vitro. J Allergy Clin Immunol 1998;101(6 Pt 1):778-785.   DOI   ScienceOn
79 Bayram H, Devalia JL, Khair OA, et al. Comparison of ciliary activity and inflammatory mediator release from bronchial epithelial cells of nonatopic nonasthmatic subjects and atopic asthmatic patients and the effect of diesel exhaust particles in vitro. J Allergy Clin Immunol 1998;102:771-782.   DOI   ScienceOn
80 Takizawa H, Abe S, Ohtoshi T, et al. Diesel exhaust particles up-regulate expression of intercellular adhesion molecule-1 (ICAM-1) in human bronchial epithelial cells. Clin Exp Immunol 2000;120:356-362.   DOI   ScienceOn
81 Takizawa H, Ohtoshi T, Kawasaki S, et al. Diesel exhaust particles induce NF-kappa B activation in human bronchial epithelial cells in vitro: importance in cytokine transcription. J Immunol 1999;162:4705-4711.
82 Takizawa H, Abe S, Okazaki H, et al. Diesel exhaust particles upregulate eotaxin gene expression in human bronchial epithelial cells via nuclear factor-kappa B-dependent pathway. Am J Physiol Lung Cell Mol Physiol 2003;284:L1055-L1062.   DOI
83 Li N, Wang M, Oberley TD, Sempf JM, Nel AE. Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages. J Immunol 2002;169:4531-4541.   DOI
84 Bommel H, Haake M, Luft P, et al. The diesel exhaust component pyrene induces expression of IL-8 but not of eotaxin. Int Immunopharmacol 2003;3:1371-1379.   DOI   ScienceOn
85 Hashimoto S, Gon Y, Takeshita I, et al. Diesel exhaust particles activate p38 MAP kinase to produce interleukin 8 and RANTES by human bronchial epithelial cells and N-acetylcysteine attenuates p38 MAP kinase activation. Am J Respir Crit Care Med 2000;161:280-285.   DOI   ScienceOn
86 Boland S, Bonvallot V, Fournier T, Baeza-Squiban A, Aubier M, Marano F. Mechanisms of GM-CSF increase by diesel exhaust particles in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 2000;278:L25-L32.   DOI
87 Salvi S, Blomberg A, Rudell B, et al. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J Respir Crit Care Med 1999;159:702-709.   DOI   ScienceOn
88 Salvi SS, Nordenhall C, Blomberg A, et al. Acute exposure to diesel exhaust increases IL-8 and GRO-alpha production in healthy human airways. Am J Respir Crit Care Med 2000;161(2 Pt 1):550-557.
89 Stenfors N, Nordenhall C, Salvi SS, et al. Different airway inflammatory responses in asthmatic and healthy humans exposed to diesel. Eur Respir J 2004;23:82-86.   DOI   ScienceOn
90 Holgate ST, Sandstrom T, Frew AJ, et al. Health effects of acute exposure to air pollution. Part I: Healthy and asthmatic subjects exposed to diesel exhaust. Res Rep Health Eff Inst 2003;(112):1-30.
91 Kradin RL, Sakamoto H, Jain F, Zhao LH, Hymowitz G, Preffer F. IL-10 inhibits inflammation but does not affect fibrosis in the pulmonary response to bleomycin. Exp Mol Pathol 2004;76:205-211.   DOI   ScienceOn
92 Di Giampaolo L, Quecchia C, Schiavone C, et al. Environmental pollution and asthma. Int J Immunopathol Pharmacol 2011;24(1 Suppl):31S-38S.   DOI
93 Zhang Q, Kleeberger SR, Reddy SP. DEP-induced fra-1 expression correlates with a distinct activation of AP-1-dependent gene transcription in the lung. Am J Physiol Lung Cell Mol Physiol 2004;286:L427-L436.   DOI   ScienceOn
94 Blanchet S, Ramgolam K, Baulig A, Marano F, Baeza-Squiban A. Fine particulate matter induces amphiregulin secretion by bronchial epithelial cells. Am J Respir Cell Mol Biol 2004;30:421-427.   DOI   ScienceOn
95 Pourazar J, Blomberg A, Kelly FJ, et al. Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium. Part Fibre Toxicol 2008;5:8.   DOI   ScienceOn
96 Xu X, Kherada N, Hong X, et al. Diesel exhaust exposure induces angiogenesis. Toxicol Lett 2009;191:57-68.   DOI   ScienceOn
97 Bonvallot V, Baeza-Squiban A, Baulig A, et al. Organic compounds from diesel exhaust particles elicit a proinflammatory response in human airway epithelial cells and induce cytochrome p450 1A1 expression. Am J Respir Cell Mol Biol 2001;25:515-521.   DOI   ScienceOn
98 Kawasaki S, Takizawa H, Takami K, et al. Benzene-extracted components are important for the major activity of diesel exhaust particles: effect on interleukin-8 gene expression in human bronchial epithelial cells. Am J Respir Cell Mol Biol 2001;24:419-426.   DOI   ScienceOn
99 Tal TL, Simmons SO, Silbajoris R, et al. Differential transcriptional regulation of IL-8 expression by human airway epithelial cells exposed to diesel exhaust particles. Toxicol Appl Pharmacol 2010;243:46-54.   DOI   ScienceOn
100 Li YJ, Takizawa H, Kawada T. Role of oxidative stresses induced by diesel exhaust particles in airway inflammation, allergy and asthma: their potential as a target of chemoprevention. Inflamm Allergy Drug Targets 2010;9:300-305.   DOI   ScienceOn
101 Muranaka M, Suzuki S, Koizumi K, et al. Adjuvant activity of diesel-exhaust particulates for the production of IgE antibody in mice. J Allergy Clin Immunol 1986;77:616-623.   DOI
102 Sagai M, Furuyama A, Ichinose T. Biological effects of diesel exhaust particles (DEP). III. Pathogenesis of asthma like symptoms in mice. Free Radic Biol Med 1996;21:199-209.   DOI   ScienceOn
103 Miyabara Y, Takano H, Ichinose T, Lim HB, Sagai M. Diesel exhaust enhances allergic airway inflammation and hyperresponsiveness in mice. Am J Respir Crit Care Med 1998;157(4 Pt 1):1138-1144.   DOI   ScienceOn
104 Takano H, Ichinose T, Miyabara Y, et al. Inhalation of diesel exhaust enhances allergen-related eosinophil recruitment and airway hyperresponsiveness in mice. Toxicol Appl Pharmacol 1998;150:328-337.   DOI   ScienceOn
105 Takano H, Yoshikawa T, Ichinose T, Miyabara Y, Imaoka K, Sagai M. Diesel exhaust particles enhance antigen-induced airway inflammation and local cytokine expression in mice. Am J Respir Crit Care Med 1997;156:36-42.   DOI   ScienceOn
106 Ohta K, Yamashita N, Tajima M, et al. Diesel exhaust particulate induces airway hyperresponsiveness in a murine model: essential role of GM-CSF. J Allergy Clin Immunol 1999;104:1024-1030.   DOI   ScienceOn
107 Ichinose T, Takano H, Miyabara Y, Sagai M. Long-term exposure to diesel exhaust enhances antigen-induced eosinophilic inflammation and epithelial damage in the murine airway. Toxicol Sci 1998;44:70-79.   DOI   ScienceOn
108 Matsumoto A, Hiramatsu K, Li Y, et al. Repeated exposure to low-dose diesel exhaust after allergen challenge exaggerates asthmatic responses in mice. Clin Immunol 2006;121:227-235.   DOI   ScienceOn