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http://dx.doi.org/10.3904/kjim.2011.26.2.213

Complete Atrioventricular Block in Adult Sjogren's Syndrome with Anti-Ro Autoantibody  

Sung, Myung-Jun (Department of Internal Medicine, Catholic University of Daegu School of Medicine, Arthritis and Autoimmunity Research Center)
Park, Sung-Hoon (Department of Internal Medicine, Catholic University of Daegu School of Medicine, Arthritis and Autoimmunity Research Center)
Kim, Seong-Kyu (Department of Internal Medicine, Catholic University of Daegu School of Medicine, Arthritis and Autoimmunity Research Center)
Lee, Young-Soo (Department of Internal Medicine, Catholic University of Daegu School of Medicine, Arthritis and Autoimmunity Research Center)
Park, Chul-Yeon (Department of Internal Medicine, Catholic University of Daegu School of Medicine, Arthritis and Autoimmunity Research Center)
Choe, Jung-Yoon (Department of Internal Medicine, Catholic University of Daegu School of Medicine, Arthritis and Autoimmunity Research Center)
Publication Information
The Korean journal of internal medicine / v.26, no.2, 2011 , pp. 213-215 More about this Journal
Abstract
Anti-Ro autoantibody is associated with Sj${\ddot{o}}$gren's syndrome (SS), systemic lupus erythematosus (SLE), and neonatal lupus syndrome (i.e., congenital complete heart block in newborns). Generally, the adult atrioventricular (AV) node is believed to be relatively resistant to the scarring effects of anti-Ro/anti-La autoantibodies. However, there have been some reports of adult complete AV block in SS and SLE patients. Here, we report a case of complete heart block in primary SS with anti-Ro autoantibodies, with no other risk factor for the development of heart block, and review their etiological association.
Keywords
Ro antibodies; Sj${\ddot{o}}$gren's syndrome; Atrioventricular block;
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1 Kassan SS, Moutsopoulos HM. Clinical manifestations and early diagnosis of Sjogren syndrome. Arch Intern Med 2004;164:1275-1284.   DOI   ScienceOn
2 Lee LA. Transient autoimmunity related to maternal autoantibodies: neonatal lupus. Autoimmun Rev 2005;4:207-213.   DOI   ScienceOn
3 Boutjdir M. Molecular and ionic basis of congenital complete heart block. Trends Cardiovasc Med 2000;10:114-122.   DOI   ScienceOn
4 Lee LA, Pickrell MB, Reichlin M. Development of complete heart block in an adult patient with Sjogren's syndrome and anti-Ro/SS-A autoantibodies. Arthritis Rheum 1996;39:1427-1429.   DOI   ScienceOn
5 Maier WP, Ramirez HE, Miller SB. Complete heart block as the initial manifestation of systemic lupus erythematosus. Arch Intern Med 1987;147:170-171.   DOI   ScienceOn
6 Mevorach D, Raz E, Shalev O, Steiner I, Ben-Chetrit E. Complete heart block and seizures in an adult with systemic lupus erythematosus: a possible pathophysiologic role for anti-SS-A/Ro and anti-SS-B/La autoantibodies. Arthritis Rheum 1993;36:259-262.   DOI   ScienceOn
7 Salomonsson S, Wahren-Herlenius M. Local production of Ro/SSA and La/SSB autoantibodies in the target organ coincides with high levels of circulating antibodies in sera of patients with Sjogren's syndrome. Scand J Rheumatol 2003;32:79-82.   DOI   ScienceOn
8 Reichlin M, Brucato A, Frank MB, et al. Concentration of autoantibodies to native 60-kd Ro/SS-A and denatured 52-kd Ro/SS-A in eluates from the heart of a child who died with congenital complete heart block. Arthritis Rheum 1994;37:1698-1703.   DOI   ScienceOn
9 Alexander E, Buyon JP, Provost TT, Guarnieri T. Anti-Ro/SS-A antibodies in the pathophysiology of congenital heart block in neonatal lupus syndrome, an experimental model: in vitro electrophysiologic and immunocytochemical studies. Arthritis Rheum 1992;35:176-189.   DOI   ScienceOn
10 Garcia S, Nascimento JH, Bonfa E, et al. Cellular mechanism of the conduction abnormalities induced by serum from anti-Ro/SSA-positive patients in rabbit hearts. J Clin Invest 1994;93:718-724.   DOI   ScienceOn