Clinical Significance of Observation without Repeated Radioiodine Therapy in Differentiated Thyroid Carcinoma Patients with Positive Surveillance Whole-Body Scans and Negative Thyroglobulin
![]() |
Lim, Dong-Jun
(Division of Endocrinology and Metabolism, Department of Internal Medicine, The Catholic University of Korea School of Medicine)
O, Joo-Hyun (Department of Nuclear Medicine, The Catholic University of Korea School of Medicine) Kim, Min-Hee (Division of Endocrinology and Metabolism, Department of Internal Medicine, The Catholic University of Korea School of Medicine) Kim, Ji-Hyun (Division of Endocrinology and Metabolism, Department of Internal Medicine, The Catholic University of Korea School of Medicine) Kwon, Hyuk-Sang (Division of Endocrinology and Metabolism, Department of Internal Medicine, The Catholic University of Korea School of Medicine) Kim, Sung-Hoon (Division of Endocrinology and Metabolism, Department of Internal Medicine, The Catholic University of Korea School of Medicine) Kang, Moo-Il (Division of Endocrinology and Metabolism, Department of Internal Medicine, The Catholic University of Korea School of Medicine) Cha, Bong-Yun (Division of Endocrinology and Metabolism, Department of Internal Medicine, The Catholic University of Korea School of Medicine) Lee, Kwang-Woo (Division of Endocrinology and Metabolism, Department of Internal Medicine, The Catholic University of Korea School of Medicine) Son, Ho-Young (Division of Endocrinology and Metabolism, Department of Internal Medicine, The Catholic University of Korea School of Medicine) |
1 | Caballero-Calabuig E, Cano-Terol C, Sopena-Monforte R, et al. Influence of the thyroid remnant in the elevation of the serum thyroglobulin after thyroidectomy in differentiated thyroid carcinoma. Importance of the diagnostic iodine total-body scanning. Eur J Nucl Med Mol Imaging 2008;35:1449-1456. DOI ScienceOn |
2 | Brown AP, Chen J, Hitchcock YJ, Szabo A, Shrieve DC, Tward JD. The risk of second primary malignancies up to three decades after the treatment of differentiated thyroid cancer. J Clin Endocrinol Metab 2008;93:504-515. DOI ScienceOn |
3 | Bachelot A, Cailleux AF, Klain M, et al. Relationship between tumor burden and serum thyroglobulin level in patients with papillary and follicular thyroid carcinoma. Thyroid 2002;12:707-711. DOI ScienceOn |
4 | Pacini F, Capezzone M, Elisei R, Ceccarelli C, Taddei D, Pinchera A. Diagnostic 131-iodine whole-body scan may be avoided in thyroid cancer patients who have undetectable stimulated serum Tg levels after initial treatment. J Clin Endocrinol Metab 2002;87:1499-1501. DOI ScienceOn |
5 | Schlumberger M, Berg G, Cohen O, et al. Follow-up of low-risk patients with differentiated thyroid carcinoma: a European perspective. Eur J Endocrinol 2004;150:105-112. DOI ScienceOn |
6 | Torlontano M, Attard M, Crocetti U, et al. Follow-up of low risk patients with papillary thyroid cancer: role of neck ultrasonography in detecting lymph node metastases. J Clin Endocrinol Metab 2004;89:3402-3407. DOI |
7 | Pacini F, Schlumberger M, Dralle H, Elisei R, Smit JW, Wiersinga W. European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium. Eur J Endocrinol 2006;154:787-803. DOI ScienceOn |
8 | American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, Cooper DS, Doherty GM, et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 2009;19:1167-1214. DOI ScienceOn |
9 | Urhan M, Dadparvar S, Mavi A, et al. Iodine-123 as a diagnostic imaging agent in differentiated thyroid carcinoma: a comparison with iodine-131 post-treatment scanning and serum thyroglobulin measurement. Eur J Nucl Med Mol Imaging 2007;34:1012-1017. DOI ScienceOn |
10 | Müller-Gärtner HW, Schneider C. Clinical evaluation of tumor characteristics predisposing serum thyroglobulin to be undetectable in patients with differentiated thyroid cancer. Cancer 1988;61:976-981. DOI ScienceOn |
11 | Hyer S, Kong A, Pratt B, Harmer C. Salivary gland toxicity after radioiodine therapy for thyroid cancer. Clin Oncol (R Coll Radiol) 2007;19:83-86. DOI ScienceOn |
12 | Alzahrani AS, Bakheet S, Al Mandil M, Al-Hajjaj A, Almahfouz A, Al Haj A. 123I isotope as a diagnostic agent in the follow-up of patients with differentiated thyroid cancer: comparison with post 131I therapy whole body scanning. J Clin Endocrinol Metab 2001;86:5294-5300. DOI ScienceOn |
13 | Baudin E, Do Cao C, Cailleux AF, Leboulleux S, Travagli JP, Schlumberger M. Positive predictive value of serum thyroglobulin levels, measured during the first year of follow-up after thyroid hormone withdrawal, in thyroid cancer patients. J Clin Endocrinol Metab 2003;88:1107-1111. DOI ScienceOn |
14 | Mazzaferri EL, Robbins RJ, Spencer CA, et al. A consensus report of the role of serum thyroglobulin as a monitoring method for low-risk patients with papillary thyroid carcinoma. J Clin Endocrinol Metab 2003;88:1433-1441. DOI ScienceOn |
15 | Rubino C, de Vathaire F, Dottorini ME, et al. Second primary malignancies in thyroid cancer patients. Br J Cancer 2003;89:1638-1644. DOI ScienceOn |
16 | Ronckers CM, McCarron P, Ron E. Thyroid cancer and multiple primary tumors in the SEER cancer registries. Int J Cancer 2005;117:281-288. DOI ScienceOn |
17 | Alexander C, Bader JB, Schaefer A, Finke C, Kirsch CM. Intermediate and long-term side effects of high-dose radioiodine therapy for thyroid carcinoma. J Nucl Med 1998;39:1551-1554. |
18 | Park EK, Chung JK, Lim IH, et al. Recurrent/metastatic thyroid carcinomas false negative for serum thyroglobulin but positive by posttherapy I-131 whole body scans. Eur J Nucl Med Mol Imaging 2009;36:172-179. DOI ScienceOn |
19 | Schlumberger MJ, Pacini F. The low utility of pretherapy scans in thyroid cancer patients. Thyroid 2009;19:815-816. DOI ScienceOn |
20 | Van Nostrand D, Aiken M, Atkins F, et al. The utility of radioiodine scans prior to iodine 131 ablation in patients with well-differentiated thyroid cancer. Thyroid 2009;19:849-855. DOI ScienceOn |
21 | McDougall IR. The case for obtaining a diagnostic whole-body scan prior to iodine 131 treatment of differentiated thyroid cancer. Thyroid 2009;19:811-813. DOI ScienceOn |
22 | Cailleux AF, Baudin E, Travagli JP, Ricard M, Schlumberger M. Is diagnostic iodine-131 scanning useful after total thyroid ablation for differentiated thyroid cancer? J Clin Endocrinol Metab 2000;85:175-178. DOI ScienceOn |
![]() |