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http://dx.doi.org/10.4110/in.2014.14.2.81

Preclinical Efficacy and Mechanisms of Mesenchymal Stem Cells in Animal Models of Autoimmune Diseases  

Lee, Hong Kyung (College of Pharmacy, Chungbuk National University)
Lim, Sang Hee (College of Pharmacy, Chungbuk National University)
Chung, In Sung (College of Pharmacy, Chungbuk National University)
Park, Yunsoo (College of Pharmacy, Chungbuk National University)
Park, Mi Jeong (College of Pharmacy, Chungbuk National University)
Kim, Ju Young (College of Pharmacy, Chungbuk National University)
Kim, Yong Guk (College of Pharmacy, Chungbuk National University)
Hong, Jin Tae (College of Pharmacy, Chungbuk National University)
Kim, Youngsoo (College of Pharmacy, Chungbuk National University)
Han, Sang-Bae (College of Pharmacy, Chungbuk National University)
Publication Information
IMMUNE NETWORK / v.14, no.2, 2014 , pp. 81-88 More about this Journal
Abstract
Mesenchymal stem cells (MSCs) are present in diverse tissues and organs, including bone marrow, umbilical cord, adipose tissue, and placenta. MSCs can expand easily in vitro and have regenerative stem cell properties and potent immunoregulatory activity. They inhibit the functions of dendritic cells, B cells, and T cells, but enhance those of regulatory T cells by producing immunoregulatory molecules such as transforming growth factor-${\beta}$, hepatic growth factors, prostaglandin $E_2$, interleukin-10, indolamine 2,3-dioxygenase, nitric oxide, heme oxygenase-1, and human leukocyte antigen-G. These properties make MSCs promising therapeutic candidates for the treatment of autoimmune diseases. Here, we review the preclinical studies of MSCs in animal models for systemic lupus erythematosus, rheumatoid arthritis, Crohn's disease, and experimental autoimmune encephalomyelitis, and summarize the underlying immunoregulatory mechanisms.
Keywords
Mesenchymal stem cells; Immunoregulation; Autoimmune diseases;
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