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The Effects of an RF Plasma and Electric Fields on the Death of G361 Melanoma Cells  

Shon, Chae-Hwa (한국전기연구원 전기물리연구그룹)
Kim, Gyoo-Cheon (부산대학교 치의학과)
Lee, Hae-June (부산대학교 전자전기통신공학부)
Publication Information
The Transactions of The Korean Institute of Electrical Engineers / v.56, no.11, 2007 , pp. 1972-1977 More about this Journal
Abstract
Micro plasma has been recently studied to investigate the effects on various cells. We study a micro-plasma produced by a plasma needle that is operated with RF power and its effects on G361 melanoma cells. The micro plasma size ranges from sub-mm to several mm at a few watts of RF power. For the bio-medical treatment, low-temperature plasma is obtained and gas temperature is controlled within several tens of degrees $(^{\circ}C)$ in order not to disturb cell activities. Elementary spectroscopic studies to obtain plasma characteristics are presented for Ar and He plasma with different frequencies of RF power. Also the preliminary results of the micro plasma effects on G361 melanoma cells are presented. It was observed that the irradiation of micro plasma induces cell death through the deprivation of tyrosine phosphorylation in the G361 cells.
Keywords
micro plasma; low-temperature plasma; melanoma; apoptosis; plasma needle;
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