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http://dx.doi.org/10.3795/KSME-B.2012.36.11.1081

Longitudinal Tracking of Alteration Pattern on Trabecular Bone Microarchitecture at Tibial Epiphysis Induced by Post Traumatic Osteoarthritis Over Time  

Lee, Joo-Hyung (Dept. of Mechanical Engineering, Sejong Univ.)
Chun, Keyoung-Jin (Silver Technology Research Group, Korea Institute of Industrial Technology)
Lee, Kwon-Young (Dept. of Mechanical Engineering, Sejong Univ.)
Kim, Dae-Jun (Dept. of Advanced Material Engineering, Sejong Univ.)
Kim, Han-Sung (Dept. Biomedical Engineering, Yonsei Univ.)
Lim, Do-Hyung (Dept. of Mechanical Engineering, Sejong Univ.)
Publication Information
Transactions of the Korean Society of Mechanical Engineers B / v.36, no.11, 2012 , pp. 1081-1090 More about this Journal
Abstract
This study aims to track the longitudinal alteration pattern on the trabecular bone microarchitecture at tibial epiphysis induced by T-OA over time using in vivo micro computed tomography (${\mu}CT$). Ten SD rats were divided into control (n = 5) and T-OA (n = 5) groups. Anterior cruciate ligament transaction was performed for the T-OA group. The results showed that the alteration pattern on the trabecular bone microarchitecture at tibial epiphysis in the T.OA group was definitely different compared with that in the CON group from 0 to 8 weeks (approximately 4-16%, P > 0.05). In particular, a difference was observed in the bone formation and density distributions over time (from 0 or 4 to 8 weeks; approximately 5.15%, P < 0.05). An improved understanding of the alteration pattern on the trabecular bone microarchitecture at tibial epiphysis may assist in developing more targeted treatment interventions for T-OA.
Keywords
Post Traumatic Osteoarthritis; Trabecular Bone Microarchitecture; Tibial Epiphysis; Alteration Pattern; Longitudinal Tracking;
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