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http://dx.doi.org/10.22643/JRMP.2022.8.1.17

Development of evaluation of B/F benzothiazole analogues for boron neutron capture therapy  

Ji-ung Yang (Division of Applied RI, Korea Institute of Radiological & Medical Sciences (KIRAMS))
Soyeon Kim (Division of Applied RI, Korea Institute of Radiological & Medical Sciences (KIRAMS))
Kyo Chul Lee (Division of Applied RI, Korea Institute of Radiological & Medical Sciences (KIRAMS))
Yong Jin Lee (Division of Applied RI, Korea Institute of Radiological & Medical Sciences (KIRAMS))
Jung Young Kim (Division of Applied RI, Korea Institute of Radiological & Medical Sciences (KIRAMS))
Ji-Ae Park (Division of Applied RI, Korea Institute of Radiological & Medical Sciences (KIRAMS))
Publication Information
Journal of Radiopharmaceuticals and Molecular Probes / v.8, no.1, 2022 , pp. 17-23 More about this Journal
Abstract
Boron neutron capture therapy is a precision treatment technology that selectively destroys only tumor cells by irradiating thermal neutrons after accumulating boron drugs in tumor cells. Brain tumor is difficult to diagnose and treat due to the low permeability and targeting of drugs caused by the blood-brain-barrier. Crossing the BBB is essential for drug delivery to the brain. In this study, we designed and synthesized a novel compound incorporating benzothiazole to develop a boron drug with high BBB permeability and selectivity for brain tumor cells. In addition, their potential as a BNCT drugs was evaluated.
Keywords
Boron neutron capture therapy; Benzothiazole; Blood-brain-barrier; Boron drugs;
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Times Cited By KSCI : 2  (Citation Analysis)
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