Browse > Article
http://dx.doi.org/10.22643/JRMP.2018.4.1.22

Molar activity of radiopharmaceuticals  

Choe, Yearn Seong (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea and Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University)
Publication Information
Journal of Radiopharmaceuticals and Molecular Probes / v.4, no.1, 2018 , pp. 22-25 More about this Journal
Abstract
Radiopharmaceuticals are used for diagnosis or therapy of diseases. According to the recent consensus nomenclature rules for radiopharmaceutical chemistry, specific activity is defined as the radioactivity per gram of radiolabeled compound and molar activity as the radioactivity per mole of radiolabeled compound. In this review, molar activity of radiopharmaceuticals is discussed in terms of its significance in nuclear imaging as well as its measurement methods.
Keywords
Radiopharmaceutical; Molar activity; Specific activity; Carrier;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Coenen HH, Gee AD, Adam M, Antoni G, Cutler CS, Fujibayashi Y, Jeong JM, Mach RH, Mindt TL, Pike VW, Windhorst AD. Consensus nomenclature rules for radiopharmaceutical chemistry — Setting the record straight. Nucl Med Biol 2017;55:v-xi.   DOI
2 Schlyer DJ. PET tracers and radiochemistry. Ann Acad Med Singapore 2004;33:146-154.
3 Berridge MS, Apana SM, Hersh JM. Teflon radiolysis as the major source of carrier in fluorine-18. J Label Compd Radiopharm 2009;52:543-548.   DOI
4 Sihver W, Langstrom B, Nordberg A. Ligands for in vivo imaging of nicotinic receptor subtypes in Alzheimer brain. Acta Neurol Scand 2002;Suppl 176:27-33.
5 Villemagne VL, Horti A, Scheffel U, Ravert HT, Finley P, Clough DJ, London ED, Henry N. Wagner, Jr HN,Dannals RF. Imaging nicotinic acetylcholine receptors with fiuorine-18-FPH: an epibatidine analog. J Nucl Med 1997;38:1737-1741.
6 Van Daele PG, De Bruyn MF, Boey JM, Sanczuk S, Agten JT, Janssen PA. Synthetic analgesics: N-(1-[2-arylethyl]-4-substituted 4-piperidinyl) N-arylalkanamides. Arzneim-Forsch (Drug Res). 1976;26:1521-1531.
7 Blecha JE, Henderson BD, Hockley BG, VanBrocklin HF, Zubieta JK, DaSilva AF, Kilbourn MR, Koeppe RA, Scott PJH, Shao X. An updated synthesis of $[^{11}C]$ carfentanil for positron emission tomography (PET) imaging of the ${\mu}-opioid$ receptor. J Label Compd Radiopharm 2017;60:375-380.   DOI
8 Monographs on radiopharmaceutical preparations and starting materials for radiopharmaceutical preparations.In: Council of Europe. European Pharmacopoeia. 9th ed. Vol. I. Strasbourg. 2017. p. 1125-1204.