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http://dx.doi.org/10.5653/cerm.2021.05099

Prevalence of Y chromosome microdeletions among infertile Mongolian men  

Damdinsuren, Erdenesuvd (Department of Obstetrics and Gynecology, Mongolian National University of Medical Sciences School of Medicine)
Naidansuren, Purevjargal (Mon-CL Fertility Center)
Gochoo, Mendsaikhan (Department of Obstetrics and Gynecology, Mongolian National University of Medical Sciences School of Medicine)
Choi, Bum-Chae (Mon-CL Fertility Center)
Choi, Min-Youp (Center for Recurrent Miscarriage and Infertility, Creation and Love Women's Hospital)
Baldandorj, Bolorchimeg (Department of Obstetrics and Gynecology, Mongolian National University of Medical Sciences School of Medicine)
Publication Information
Clinical and Experimental Reproductive Medicine / v.49, no.2, 2022 , pp. 101-109 More about this Journal
Abstract
Objective: Y chromosome microdeletions are the second most common genetic cause of male infertility after Klinefelter syndrome. The aim of this study was to determine the patterns of Y chromosome microdeletions among infertile Mongolian men. Methods: A descriptive study was performed on 75 infertile men from February 2017 to December 2018. Y chromosome microdeletions were identified by polymerase chain reaction. Semen parameters, hormonal levels, and testis biopsy samples were examined. Results: Among 75 infertile men, two cases of Y chromosome microdeletions were identified. The first case had an AZFa complete deletion and the other had an AZFc partial deletion. This study found that the proportion of Y chromosome microdeletions among infertile Mongolian men was 2.66%. Conclusion: The findings can be applied to in vitro fertilization and assisted reproductive technology, and our results will help clinicians improve treatment management for infertile Mongolian couples.
Keywords
Azoospermia; Infertility; Semen analysis; Y chromosome;
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