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Outcome of in vitro Fertilization in Women $\geq$40 Years of Age  

Kwon, Cheo-Jin (Infertility Center, Seoul Women's Hospital)
Lee, Sang-Hee (Department of Obstetrics & Gynecology, Seoul Women's Hospital)
Kang, Eun-Hee (Department of Obstetrics & Gynecology, Seoul Women's Hospital)
Kim, Jong-Sik (Infertility Center, Seoul Women's Hospital)
Jung, Byeong-Jun (Department of Obstetrics & Gynecology, Seoul Women's Hospital)
Publication Information
Clinical and Experimental Reproductive Medicine / v.34, no.4, 2007 , pp. 285-291 More about this Journal
Abstract
Objective: To evaluate the outcomes of in vitro fertilization and embryo transfer (IVF-ET) in women over 40 years of age. Methods: A total of 170 patients (271 cycles) over 40 years of age who underwent IVF-ET at Seoul Women's Hospital (Incheon, Korea) were analyzed in this study retrospectively. The patients were grouped into the women <44 years old group and the women $\geq$44 years old group. Statistical analysis was performed using Student's t-test and Fisher's exact test as appropriate. Results: An overall clinical pregnancy rate per retrieval was 11% (30/271). Of these, clinical miscarriage rate were 33% (10/30) and the overall delivery rate was 7.4% (20/271) per retrieval, respectively. The women $\geq$44 years old group had significantly higher cancellation rate (13% vs. 25%), lower number of retrieved oocytes (6.17$\times$4.62 vs. 4.13$\times$4.07), decreased number of 2PN (4.83$\times$3.61 vs. 3.46$\times$3.12), and reduced embryos for transfer (3.52$\times$1.72 vs. 2.81$\times$1.83) than the women <44 years old group. We found significantly lower clinical pregnancy rate (13.0% vs. 2.1%) and live birth rate (9.0% vs. 0.0%) in the women $\geq$44 years old group than the women <44 years old group. Conclusion: The present study has shown that IVF outcome is seriously impaired in the women $\geq$44 years old.
Keywords
Maternal age; IVF outcome; Delivery rate; Miscarriage rate;
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